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Aliases for C9orf163 Gene

Aliases for C9orf163 Gene

  • Chromosome 9 Open Reading Frame 163 2 3 5

External Ids for C9orf163 Gene

Previous GeneCards Identifiers for C9orf163 Gene

  • GC09P138497
  • GC09P139377
  • GC09P108837

Summaries for C9orf163 Gene

GeneCards Summary for C9orf163 Gene

C9orf163 (Chromosome 9 Open Reading Frame 163) is a Protein Coding gene.

Additional gene information for C9orf163 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf163 Gene

Genomics for C9orf163 Gene

GeneHancer (GH) Regulatory Elements for C9orf163 Gene

Promoters and enhancers for C9orf163 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I136481 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 183 4.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SEC16A C9orf163 INPP5E SNHG7 SNAPC4 SDCCAG3 ANAPC2 NDOR1
GH09I136537 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 +59.8 59791 10.7 HDGF PKNOX1 CLOCK SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 ZNF207 NOTCH1 ENSG00000227512 NALT1 SEC16A SDCCAG3 C9orf163 SNHG7 INPP5E ANAPC2 FUT7
GH09I136642 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +161.6 161595 5.8 HDGF PKNOX1 CLOCK ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B LOC105376325 EGFL7 AGPAT2 FAM69B SEC16A C9orf163 MAN1B1 ARRDC1-AS1 NOTCH1 UAP1L1
GH09I136549 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +68.3 68348 4.5 HDGF GLIS2 ZNF416 FOS SP3 SMARCB1 ZNF623 ATF4 SMARCA4 NBN INPP5E SEC16A C9orf163 TMEM203 NOTCH1 NALT1 SDCCAG3 TMEM141 MIR4674 LINC01451
GH09I136586 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +104.6 104648 3.5 ATF1 SIN3A ETS1 TCF12 ZNF766 GLIS2 ARID2 ZNF143 ATF7 REST NALT1 ENSG00000227512 C9orf163 LINC01451 MIR4674
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C9orf163 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C9orf163 gene promoter:

Genomic Locations for C9orf163 Gene

Genomic Locations for C9orf163 Gene
chr9:136,483,495-136,486,067
(GRCh38/hg38)
Size:
2,573 bases
Orientation:
Plus strand
chr9:139,377,947-139,380,519
(GRCh37/hg19)

Genomic View for C9orf163 Gene

Genes around C9orf163 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf163 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf163 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf163 Gene

Proteins for C9orf163 Gene

  • Protein details for C9orf163 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9P6-CI163_HUMAN
    Recommended name:
    Uncharacterized protein C9orf163
    Protein Accession:
    Q8N9P6

    Protein attributes for C9orf163 Gene

    Size:
    203 amino acids
    Molecular mass:
    22154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C9orf163 Gene

Post-translational modifications for C9orf163 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf163 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C9orf163 Gene

Domains & Families for C9orf163 Gene

Protein Domains for C9orf163 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf163: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf163 Gene

Function for C9orf163 Gene

Phenotypes for C9orf163 Gene

GenomeRNAi human phenotypes for C9orf163:
genes like me logo Genes that share phenotypes with C9orf163: view

Animal Model Products

CRISPR Products

miRNA for C9orf163 Gene

miRTarBase miRNAs that target C9orf163

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf163 Gene

Localization for C9orf163 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf163 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C9orf163 Gene

Pathways & Interactions for C9orf163 Gene

SuperPathways for C9orf163 Gene

No Data Available

Interacting Proteins for C9orf163 Gene

Selected Interacting proteins: Q8N9P6-CI163_HUMAN for C9orf163 Gene via IID

Symbol External ID(s) Details
LRRK1
VDAC1

Gene Ontology (GO) - Biological Process for C9orf163 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf163 Gene

Drugs & Compounds for C9orf163 Gene

No Compound Related Data Available

Transcripts for C9orf163 Gene

mRNA/cDNA for C9orf163 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C9orf163 Gene

Chromosome 9 open reading frame 163:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf163 Gene

No ASD Table

Relevant External Links for C9orf163 Gene

GeneLoc Exon Structure for
C9orf163
ECgene alternative splicing isoforms for
C9orf163

Expression for C9orf163 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf163 Gene

mRNA differential expression in normal tissues according to GTEx for C9orf163 Gene

This gene is overexpressed in Testis (x6.0) and Pituitary (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of C9orf163 Gene:

C9orf163

SOURCE GeneReport for Unigene cluster for C9orf163 Gene:

Hs.212613
genes like me logo Genes that share expression patterns with C9orf163: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf163 Gene

Orthologs for C9orf163 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C9orf163 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9orf163 34
  • 99 (a)
OneToOne
Species where no ortholog for C9orf163 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf163 Gene

ENSEMBL:
Gene Tree for C9orf163 (if available)
TreeFam:
Gene Tree for C9orf163 (if available)

Paralogs for C9orf163 Gene

No data available for Paralogs for C9orf163 Gene

Variants for C9orf163 Gene

Sequence variations from dbSNP and Humsavar for C9orf163 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000051242 -- 136,484,519(+) C/G/T coding_sequence_variant, missense_variant
rs1000083247 -- 136,482,637(+) G/T upstream_transcript_variant
rs1000457649 -- 136,486,284(+) C/T downstream_transcript_variant
rs1001312323 -- 136,482,481(+) T/C upstream_transcript_variant
rs1001611182 -- 136,484,247(+) G/A/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf163 Gene

Variant ID Type Subtype PubMed ID
esv2759720 CNV loss 17122850
esv30005 CNV loss 17803354
nsv1161916 CNV deletion 26073780
nsv469918 CNV loss 18288195
nsv825173 CNV gain 20364138
nsv951202 CNV deletion 24416366

Variation tolerance for C9orf163 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C9orf163 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C9orf163

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf163 Gene

Disorders for C9orf163 Gene

Additional Disease Information for C9orf163

No disorders were found for C9orf163 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf163 Gene

Publications for C9orf163 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing RM … Figeys D (Molecular systems biology 2007) 3 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C9orf163 Gene

Sources for C9orf163 Gene

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