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Aliases for C9orf16 Gene

Aliases for C9orf16 Gene

  • Chromosome 9 Open Reading Frame 16 2 3 5
  • UPF0184 Protein C9orf16 3
  • EST00098 3

External Ids for C9orf16 Gene

Previous GeneCards Identifiers for C9orf16 Gene

  • GC09P122037
  • GC09P122569
  • GC09P124376
  • GC09P126298
  • GC09P128002
  • GC09P129963
  • GC09P130922
  • GC09P100536

Summaries for C9orf16 Gene

GeneCards Summary for C9orf16 Gene

C9orf16 (Chromosome 9 Open Reading Frame 16) is a Protein Coding gene.

Additional gene information for C9orf16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf16 Gene

Genomics for C9orf16 Gene

GeneHancer (GH) Regulatory Elements for C9orf16 Gene

Promoters and enhancers for C9orf16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J128159 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.1 +0.8 758 1.9 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 E2F8 C9orf16 NUP188 ZNF79 CIZ1 NAIF1 GLE1 SNORA65 ODF2 URM1 GOLGA2
GH09J128161 Enhancer 0.4 ENCODE 650.7 +1.9 1921 0.1 GLIS1 CEBPB C9orf16 GC09P128173
GH09J128096 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.3 -58.6 -58552 9 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC25A25 NAIF1 PTGES2 CIZ1 ZNF79 PTGES2-AS1 NUP188 SLC25A25-AS1 LCN2 C9orf16
GH09J127962 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10 -186.1 -186077 22.2 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D PIP5KL1 NAIF1 DPM2 LOC100129352 NUP188 ENSG00000227218 ZNF79 ODF2 GLE1 SLC25A25
GH09J128090 Promoter/Enhancer 1.7 EPDnew ENCODE dbSUPER 11.4 -66.2 -66188 5.3 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A YY1 TCF12 POLR2B SLC25A25 ENSG00000230536 GC09P128094 SLC25A25-AS1 PTGES2-AS1 PTGES2 NAIF1 ENSG00000230848 LCN2 C9orf16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C9orf16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C9orf16 gene promoter:

Genomic Locations for C9orf16 Gene

Genomic Locations for C9orf16 Gene
4,504 bases
Plus strand

Genomic View for C9orf16 Gene

Genes around C9orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf16 Gene

Proteins for C9orf16 Gene

  • Protein details for C9orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0184 protein C9orf16
    Protein Accession:
    Secondary Accessions:
    • Q5SYV8
    • Q9Y3F7

    Protein attributes for C9orf16 Gene

    83 amino acids
    Molecular mass:
    9054 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C9orf16 Gene

Post-translational modifications for C9orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C9orf16 Gene

Domains & Families for C9orf16 Gene

Gene Families for C9orf16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C9orf16 Gene


Suggested Antigen Peptide Sequences for C9orf16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0184 (EST00098) family.
  • Belongs to the UPF0184 (EST00098) family.
genes like me logo Genes that share domains with C9orf16: view

Function for C9orf16 Gene

Gene Ontology (GO) - Molecular Function for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C9orf16: view
genes like me logo Genes that share phenotypes with C9orf16: view

Animal Model Products

miRNA for C9orf16 Gene

miRTarBase miRNAs that target C9orf16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf16 Gene

Localization for C9orf16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf16 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C9orf16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C9orf16 Gene

Pathways & Interactions for C9orf16 Gene

SuperPathways for C9orf16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C9orf16: view

No data available for Pathways by source and SIGNOR curated interactions for C9orf16 Gene

Drugs & Compounds for C9orf16 Gene

No Compound Related Data Available

Transcripts for C9orf16 Gene

mRNA/cDNA for C9orf16 Gene

Unigene Clusters for C9orf16 Gene

Chromosome 9 open reading frame 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: -
SP2: - - -
SP4: - -

Relevant External Links for C9orf16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C9orf16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf16 Gene

mRNA differential expression in normal tissues according to GTEx for C9orf16 Gene

This gene is overexpressed in Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for C9orf16 Gene

This gene is overexpressed in Fetal Brain (51.5) and Adrenal (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C9orf16 Gene

Protein tissue co-expression partners for C9orf16 Gene

NURSA nuclear receptor signaling pathways regulating expression of C9orf16 Gene:


SOURCE GeneReport for Unigene cluster for C9orf16 Gene:


Evidence on tissue expression from TISSUES for C9orf16 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with C9orf16: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf16 Gene

Orthologs for C9orf16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C9ORF16 34
  • 100 (a)
LOC740632 33
  • 99.6 (n)
(Bos Taurus)
Mammalia C11H9orf16 34 33
  • 93.57 (n)
(Canis familiaris)
Mammalia C9H9orf16 33
  • 92.77 (n)
C9orf16 34
  • 64 (a)
(Rattus norvegicus)
Mammalia RGD1561113 33
  • 91.16 (n)
(Mus musculus)
Mammalia 1110008P14Rik 16 34 33
  • 90.36 (n)
(Monodelphis domestica)
Mammalia C9orf16 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia C9orf16 34
  • 65 (a)
(Gallus gallus)
Aves C17H9ORF16 34 33
  • 80.37 (n)
(Anolis carolinensis)
Reptilia C9orf16 34
  • 85 (a)
(Danio rerio)
Actinopterygii C5H9orf16 34
  • 60 (a)
Species where no ortholog for C9orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf16 Gene

Gene Tree for C9orf16 (if available)
Gene Tree for C9orf16 (if available)

Paralogs for C9orf16 Gene Pseudogenes for C9orf16 Gene

genes like me logo Genes that share paralogs with C9orf16: view

No data available for Paralogs for C9orf16 Gene

Variants for C9orf16 Gene

Sequence variations from dbSNP and Humsavar for C9orf16 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000077164 -- 128,159,037(+) A/T upstream_transcript_variant
rs1001073189 -- 128,160,214(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001408930 -- 128,164,238(+) C/T downstream_transcript_variant
rs1001567191 -- 128,158,289(+) G/C upstream_transcript_variant
rs1001867983 -- 128,159,767(+) C/A/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for C9orf16 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C9orf16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C9orf16 Gene

Disorders for C9orf16 Gene

Additional Disease Information for C9orf16

No disorders were found for C9orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf16 Gene

Publications for C9orf16 Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J … Fried M (Human molecular genetics 1999) 2 3 4 58
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C9orf16 Gene

Sources for C9orf16 Gene

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