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Aliases for C9orf131 Gene

Aliases for C9orf131 Gene

  • Chromosome 9 Open Reading Frame 131 2 3 5

External Ids for C9orf131 Gene

Previous GeneCards Identifiers for C9orf131 Gene

  • GC09P035034
  • GC09P034996

Summaries for C9orf131 Gene

GeneCards Summary for C9orf131 Gene

C9orf131 (Chromosome 9 Open Reading Frame 131) is a Protein Coding gene.

Additional gene information for C9orf131 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf131 Gene

Genomics for C9orf131 Gene

GeneHancer (GH) Regulatory Elements for C9orf131 Gene

Promoters and enhancers for C9orf131 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I035041 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 +1.3 1257 0.8 RXRA HLF CEBPB CEBPG ATF2 ZNF148 NFIL3 ATF4 ZNF629 CREB1 ENSG00000279608 C9orf131
GH09I035042 Promoter 0.5 EPDnew 550.8 0.0 -19 0.1 C9orf131 ENSG00000279608 LOC105376025
GH09I034987 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -47.8 -47815 10.6 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS DNAJB5 UBAP2 VCP FANCG PIGO FAM205A C9orf131 ATP8B5P RPP25L FAM205C
GH09I035069 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11 +30.8 30800 4.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A YY1 POLR2B E2F8 ZNF207 ZNF143 VCP FANCG TMEM8B FAM205A C9orf131 ENSG00000228352 ATP8B5P PIGO NPR2 RN7SL338P
GH09I035813 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 +773.6 773568 3.1 HDGF FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 TMEM8B HINT2 HMGB3P24 RNF38 SPAG8 C9orf131 ATP8B5P VCP CREB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C9orf131 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C9orf131 gene promoter:

Genomic Locations for C9orf131 Gene

Genomic Locations for C9orf131 Gene
chr9:35,041,095-35,045,991
(GRCh38/hg38)
Size:
4,897 bases
Orientation:
Plus strand
chr9:35,041,092-35,045,988
(GRCh37/hg19)

Genomic View for C9orf131 Gene

Genes around C9orf131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf131 Gene

Proteins for C9orf131 Gene

  • Protein details for C9orf131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYM1-CI131_HUMAN
    Recommended name:
    Uncharacterized protein C9orf131
    Protein Accession:
    Q5VYM1
    Secondary Accessions:
    • A6NLE6
    • E9PB26
    • Q86XC6
    • Q9UF74

    Protein attributes for C9orf131 Gene

    Size:
    1079 amino acids
    Molecular mass:
    117724 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH45643.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C9orf131 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf131 Gene

Post-translational modifications for C9orf131 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C9orf131 Gene

Domains & Families for C9orf131 Gene

Gene Families for C9orf131 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C9orf131 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf131: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf131 Gene

Function for C9orf131 Gene

Phenotypes From GWAS Catalog for C9orf131 Gene

genes like me logo Genes that share phenotypes with C9orf131: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C9orf131 Gene

Localization for C9orf131 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf131 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf131 Gene

Pathways & Interactions for C9orf131 Gene

SuperPathways for C9orf131 Gene

No Data Available

Interacting Proteins for C9orf131 Gene

Gene Ontology (GO) - Biological Process for C9orf131 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf131 Gene

Drugs & Compounds for C9orf131 Gene

No Compound Related Data Available

Transcripts for C9orf131 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf131 Gene

No ASD Table

Relevant External Links for C9orf131 Gene

GeneLoc Exon Structure for
C9orf131
ECgene alternative splicing isoforms for
C9orf131

Expression for C9orf131 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf131 Gene

mRNA differential expression in normal tissues according to GTEx for C9orf131 Gene

This gene is overexpressed in Testis (x42.6).

Protein differential expression in normal tissues from HIPED for C9orf131 Gene

This gene is overexpressed in Ovary (37.1) and Spleen (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C9orf131 Gene



Protein tissue co-expression partners for C9orf131 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C9orf131 Gene:

C9orf131

SOURCE GeneReport for Unigene cluster for C9orf131 Gene:

Hs.148250
genes like me logo Genes that share expression patterns with C9orf131: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf131 Gene

Orthologs for C9orf131 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C9orf131 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf131 33
  • 98.63 (n)
C9orf131 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H9orf131 33
  • 79.3 (n)
C9orf131 34
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8H9orf131 33
  • 76.65 (n)
mouse
(Mus musculus)
Mammalia 1700022I11Rik 33 16 34
  • 69.22 (n)
rat
(Rattus norvegicus)
Mammalia LOC100360821 33
  • 68.73 (n)
Species where no ortholog for C9orf131 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf131 Gene

ENSEMBL:
Gene Tree for C9orf131 (if available)
TreeFam:
Gene Tree for C9orf131 (if available)

Paralogs for C9orf131 Gene

No data available for Paralogs for C9orf131 Gene

Variants for C9orf131 Gene

Sequence variations from dbSNP and Humsavar for C9orf131 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000865706 -- 35,046,385(+) C/T downstream_transcript_variant
rs1002776281 -- 35,042,002(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1004398847 -- 35,040,828(+) T/C upstream_transcript_variant
rs1004451330 -- 35,040,501(+) A/C upstream_transcript_variant
rs1004710569 -- 35,046,031(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf131 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv951700 CNV deletion 24416366

Variation tolerance for C9orf131 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C9orf131 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C9orf131

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf131 Gene

Disorders for C9orf131 Gene

Additional Disease Information for C9orf131

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C9orf131 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf131 Gene

Publications for C9orf131 Gene

  1. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 58
  2. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn LW … O'Brien SJ (The Journal of infectious diseases 2010) 44 58
  3. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass AL … Elledge SJ (Science (New York, N.Y.) 2008) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for C9orf131 Gene

Sources for C9orf131 Gene

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