Aliases for C9 Gene
External Ids for C9 Gene
Previous GeneCards Identifiers for C9 Gene
This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
GeneCards Summary for C9 Gene
C9 (Complement C9) is a Protein Coding gene. Diseases associated with C9 include Complement Component 9 Deficiency and Macular Degeneration, Age-Related, 15. Among its related pathways are Complement and coagulation cascades and Innate Immune System. An important paralog of this gene is C8A.
UniProtKB/Swiss-Prot Summary for C9 Gene
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934, PubMed:30111885).