Aliases for C8orf86 Gene

Aliases for C8orf86 Gene

  • Chromosome 8 Open Reading Frame 86 2 3 5
  • Uncharacterized Protein C8orf86 3 4

External Ids for C8orf86 Gene

Previous GeneCards Identifiers for C8orf86 Gene

  • GC08M038488
  • GC08M038368
  • GC08M036903

Summaries for C8orf86 Gene

GeneCards Summary for C8orf86 Gene

C8orf86 (Chromosome 8 Open Reading Frame 86) is a Protein Coding gene.

Additional gene information for C8orf86 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C8orf86 Gene

Genomics for C8orf86 Gene

GeneHancer (GH) Regulatory Elements for C8orf86 Gene

Promoters and enhancers for C8orf86 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J038562 Enhancer 0.6 Ensembl 500.7 -1.8 -1762 1.4 USF1 ATF2 ZBTB17 KLF17 PRDM6 FEZF1 JUN KLF1 JUND ZNF366 C8orf86 ENSG00000253361 LOC105379384 RF00017-6976
GH08J038559 Enhancer 0.3 Ensembl CraniofacialAtlas 500.7 +1.1 1139 1.2 ENSG00000253361 C8orf86 LOC105379383 RF00017-6976
GH08J038526 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 28.7 +32.5 32501 3.5 EP300 ZSCAN5C TCF12 USF1 RBAK JUND FOS ZNF639 ZNF10 ZIC2 C8orf86 NSD3 ERLIN2 ENSG00000255201 ENSG00000253361 PLEKHA2 TACC1 HTRA4 lnc-LETM2-9 RF00017-6977
GH08J038986 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 18.7 -425.4 -425362 2.6 PBX2 MEIS2 BCL3 PKNOX1 ZBTB20 ZNF770 PRDM1 ADAM32 C8orf86 PLEKHA2 TM2D2 TACC1 HTRA4 lnc-C8orf86-7
GH08J038428 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +130.3 130346 3.6 ZIC2 POLR2A SIN3A FOS CEBPB RCOR1 E2F1 ZFHX2 JUND MAX DDHD2 FGFR1 BRF2 LETM2 C8orf86 TACC1 ERLIN2 piR-41306-259 ENSG00000255201 lnc-NSD3-13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8orf86 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C8orf86

Top Transcription factor binding sites by QIAGEN in the C8orf86 gene promoter:
  • aMEF-2
  • Cart-1
  • MEF-2
  • MEF-2A
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SRY

Genomic Locations for C8orf86 Gene

Genomic Locations for C8orf86 Gene
chr8:38,504,582-38,560,939
(GRCh38/hg38)
Size:
56,358 bases
Orientation:
Minus strand
chr8:38,368,352-38,386,180
(GRCh37/hg19)
Size:
17,829 bases
Orientation:
Minus strand

Genomic View for C8orf86 Gene

Genes around C8orf86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf86 Gene

Proteins for C8orf86 Gene

  • Protein details for C8orf86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUL3-CH086_HUMAN
    Recommended name:
    Uncharacterized protein C8orf86
    Protein Accession:
    Q6ZUL3
    Secondary Accessions:
    • A4QPB7

    Protein attributes for C8orf86 Gene

    Size:
    223 amino acids
    Molecular mass:
    24736 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf86 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf86 Gene

Post-translational modifications for C8orf86 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf86 Gene

No data available for DME Specific Peptides for C8orf86 Gene

Domains & Families for C8orf86 Gene

Gene Families for C8orf86 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf86 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C8orf86: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C8orf86 Gene

Function for C8orf86 Gene

Phenotypes From GWAS Catalog for C8orf86 Gene

genes like me logo Genes that share phenotypes with C8orf86: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf86 Gene

Localization for C8orf86 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf86 gene
Compartment Confidence
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C8orf86 Gene

Pathways & Interactions for C8orf86 Gene

PathCards logo

SuperPathways for C8orf86 Gene

No Data Available

Interacting Proteins for C8orf86 Gene

;

Gene Ontology (GO) - Biological Process for C8orf86 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf86 Gene

Drugs & Compounds for C8orf86 Gene

No Compound Related Data Available

Transcripts for C8orf86 Gene

mRNA/cDNA for C8orf86 Gene

5 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 RNACentral transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf86 Gene

No ASD Table

Relevant External Links for C8orf86 Gene

GeneLoc Exon Structure for
C8orf86

Expression for C8orf86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C8orf86 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf86 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for C8orf86 Gene

This gene is overexpressed in Bone (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf86 Gene



Protein tissue co-expression partners for C8orf86 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C8orf86

SOURCE GeneReport for Unigene cluster for C8orf86 Gene:

Hs.546586
genes like me logo Genes that share expression patterns with C8orf86: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf86 Gene

Orthologs for C8orf86 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C8orf86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf86 30
  • 99.33 (n)
C8orf86 31
  • 99 (a)
OneToOne
Species where no ortholog for C8orf86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf86 Gene

ENSEMBL:
Gene Tree for C8orf86 (if available)
TreeFam:
Gene Tree for C8orf86 (if available)

Paralogs for C8orf86 Gene

No data available for Paralogs for C8orf86 Gene

Variants for C8orf86 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C8orf86 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
779925 Benign: not provided 38,512,636(-) A/G SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs1378332 - p.Arg81His

Additional dbSNP identifiers (rs#s) for C8orf86 Gene

Structural Variations from Database of Genomic Variants (DGV) for C8orf86 Gene

Variant ID Type Subtype PubMed ID
esv1005442 CNV insertion 20482838
esv1028558 CNV insertion 17803354
esv1219224 CNV deletion 17803354
esv2736891 CNV deletion 23290073
esv2736892 CNV deletion 23290073
esv3543375 CNV deletion 23714750
esv6024 CNV loss 19470904
nsv1126114 CNV deletion 24896259
nsv397414 CNV insertion 16902084
nsv831295 CNV gain+loss 17160897
nsv957092 CNV deletion 24416366

Variation tolerance for C8orf86 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf86 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf86

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf86 Gene

Disorders for C8orf86 Gene

Additional Disease Information for C8orf86

No disorders were found for C8orf86 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf86 Gene

Publications for C8orf86 Gene

  1. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54
  2. High-resolution whole-genome association study of Parkinson disease. (PMID: 16252231) Maraganore DM … Ballinger DG (American journal of human genetics 2005) 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for C8orf86 Gene

Sources for C8orf86 Gene