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Aliases for C8orf76 Gene

Aliases for C8orf76 Gene

  • Chromosome 8 Open Reading Frame 76 2 3 5

External Ids for C8orf76 Gene

Previous GeneCards Identifiers for C8orf76 Gene

  • GC08M124302
  • GC08M124232
  • GC08M119557

Summaries for C8orf76 Gene

GeneCards Summary for C8orf76 Gene

C8orf76 (Chromosome 8 Open Reading Frame 76) is a Protein Coding gene. An important paralog of this gene is ZHX1-C8orf76.

Additional gene information for C8orf76 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf76 Gene

Genomics for C8orf76 Gene

GeneHancer (GH) Regulatory Elements for C8orf76 Gene

Promoters and enhancers for C8orf76 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I123240 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 314 1.9 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 C8orf76 WDYHV1 FAM83A UBA52P5 ZHX1-C8orf76
GH08I123394 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.6 -154.5 -154452 3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ATAD2 FAM91A1 DERL1 C8orf76 WDYHV1 ZHX1 IMPDH1P6 GC08M123342
GH08I123415 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.8 -175.5 -175543 2.3 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF143 WDYHV1 ATAD2 LOC105375737 DERL1 C8orf76 GC08P123445
GH08I123072 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.8 +168.4 168397 2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B TBC1D31 DERL1 C8orf76 RNY4P5 HMGB1P19
GH08I123155 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.4 +83.9 83886 3.8 CLOCK DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 PPARGC1A TRM-CAT1-1 PIR54534 FAM91A1 DERL1 FAM83A C8orf76 FAM83A-AS1 TBC1D31
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C8orf76 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf76 gene promoter:

Genomic Locations for C8orf76 Gene

Genomic Locations for C8orf76 Gene
chr8:123,219,956-123,241,398
(GRCh38/hg38)
Size:
21,443 bases
Orientation:
Minus strand
chr8:124,232,196-124,253,638
(GRCh37/hg19)

Genomic View for C8orf76 Gene

Genes around C8orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf76 Gene

Proteins for C8orf76 Gene

  • Protein details for C8orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K31-CH076_HUMAN
    Recommended name:
    Uncharacterized protein C8orf76
    Protein Accession:
    Q96K31
    Secondary Accessions:
    • Q53HC1

    Protein attributes for C8orf76 Gene

    Size:
    380 amino acids
    Molecular mass:
    43273 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf76 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf76 Gene

Post-translational modifications for C8orf76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf76 Gene

Domains & Families for C8orf76 Gene

Gene Families for C8orf76 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf76 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf76: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf76 Gene

Function for C8orf76 Gene

Phenotypes for C8orf76 Gene

genes like me logo Genes that share phenotypes with C8orf76: view

miRNA for C8orf76 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf76 Gene

Localization for C8orf76 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf76 gene
Compartment Confidence
cytosol 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf76 Gene

Pathways & Interactions for C8orf76 Gene

SuperPathways for C8orf76 Gene

No Data Available

Interacting Proteins for C8orf76 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000276704%0d%0a9606.ENSP00000263388%0d%0a
Selected Interacting proteins: ENSP00000276704 Q96K31-CH076_HUMAN for C8orf76 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C8orf76 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf76 Gene

Drugs & Compounds for C8orf76 Gene

No Compound Related Data Available

Transcripts for C8orf76 Gene

Unigene Clusters for C8orf76 Gene

Chromosome 8 open reading frame 76:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf76 Gene

No ASD Table

Relevant External Links for C8orf76 Gene

GeneLoc Exon Structure for
C8orf76
ECgene alternative splicing isoforms for
C8orf76

Expression for C8orf76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf76 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf76 Gene:

C8orf76

SOURCE GeneReport for Unigene cluster for C8orf76 Gene:

Hs.707401
genes like me logo Genes that share expression patterns with C8orf76: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf76 Gene

Orthologs for C8orf76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf76 33
  • 99.47 (n)
C8orf76 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C13H8orf76 33
  • 91.23 (n)
-- 34
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C14H8orf76 33
  • 89.01 (n)
-- 34
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1310852 33
  • 78.37 (n)
mouse
(Mus musculus)
Mammalia 9130401M01Rik 33 16 34
  • 77.99 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves C2H8ORF76 33
  • 59.91 (n)
-- 34
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c8orf76 33
  • 54.55 (n)
Str.11515 33
zebrafish
(Danio rerio)
Actinopterygii zgc:101716 33
  • 52.36 (n)
C16H8orf76 34
  • 35 (a)
OneToMany
Species where no ortholog for C8orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf76 Gene

ENSEMBL:
Gene Tree for C8orf76 (if available)
TreeFam:
Gene Tree for C8orf76 (if available)

Paralogs for C8orf76 Gene

Paralogs for C8orf76 Gene

(1) SIMAP similar genes for C8orf76 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C8orf76: view

Variants for C8orf76 Gene

Sequence variations from dbSNP and Humsavar for C8orf76 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000117185 -- 123,234,140(-) A/G intron_variant
rs1000151804 -- 123,241,124(-) C/A intron_variant
rs1000187769 -- 123,232,800(-) T/C intron_variant
rs1000288390 -- 123,231,325(-) C/T coding_sequence_variant, missense_variant
rs1000411422 -- 123,237,966(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf76 Gene

Variant ID Type Subtype PubMed ID
nsv1032827 CNV gain 25217958
nsv981978 CNV duplication 23825009

Variation tolerance for C8orf76 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf76 Gene

Disorders for C8orf76 Gene

Additional Disease Information for C8orf76

No disorders were found for C8orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf76 Gene

Publications for C8orf76 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung JG … Wang TL (PLoS genetics 2014) 3 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  5. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. (PMID: 19416867) Kim YC … Wang SM (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 58

Products for C8orf76 Gene

Sources for C8orf76 Gene

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