Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C8orf74 Gene

Aliases for C8orf74 Gene

  • Chromosome 8 Open Reading Frame 74 2 3 5
  • Uncharacterized Protein C8orf74 3

External Ids for C8orf74 Gene

Previous GeneCards Identifiers for C8orf74 Gene

  • GC08P010568
  • GC08P010569
  • GC08P010530
  • GC08P009460

Summaries for C8orf74 Gene

GeneCards Summary for C8orf74 Gene

C8orf74 (Chromosome 8 Open Reading Frame 74) is a Protein Coding gene.

Additional gene information for C8orf74 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf74 Gene

Genomics for C8orf74 Gene

GeneHancer (GH) Regulatory Elements for C8orf74 Gene

Promoters and enhancers for C8orf74 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J010672 Promoter 0.8 EPDnew 650.7 +0.0 42 0.1 RFX1 GLIS1 JUN MYNN ZNF10 ZIC2 C8orf74 RNA5SP252 RP1L1
GH08J010728 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11.8 +57.3 57256 2.6 RAD21 ZNF335 GLIS2 ZNF143 ZNF398 ZEB2 SP1 ZNF610 KLF16 GLIS1 SOX7 LOC102723313 GC08M010730 C8orf74 RP1L1 ENSG00000269918 ENSG00000258724
GH08J010798 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +127.9 127854 4 PKNOX1 ATF1 ARNT ARID4B FEZF1 ETS1 YY1 TCF12 ATF7 FOS RP1L1 C8orf74 LOC102723313 ENSG00000269918 SOX7 ENSG00000255310 GC08M010803 ENSG00000258724 GC08M010757 PINX1
GH08J010714 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +43.6 43649 3.3 HDAC1 SMAD1 ATF1 RB1 KLF17 RAD21 TCF12 EGR1 ETV6 ATF7 C8orf74 ENSG00000269918 SOX7 RP1L1 LOC102723313
GH08J010965 Enhancer 0.5 FANTOM5 26.3 +293.2 293164 0.2 IKZF1 EBF1 IKZF2 PIR55470 GC08P010967 C8orf74 PRSS55 ENSG00000254936 PIR49045 XKR6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8orf74 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf74 gene promoter:
  • Ik-2
  • Cdc5
  • Tal-1
  • E47
  • Tal-1beta
  • POU6F1 (c2)
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for C8orf74 Gene

Genomic Locations for C8orf74 Gene
28,022 bases
Plus strand
27,957 bases
Plus strand

Genomic View for C8orf74 Gene

Genes around C8orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf74 Gene

Proteins for C8orf74 Gene

  • Protein details for C8orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf74
    Protein Accession:
    Secondary Accessions:
    • A2RUD6

    Protein attributes for C8orf74 Gene

    294 amino acids
    Molecular mass:
    33735 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH65837.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C8orf74 Gene

Post-translational modifications for C8orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf74 Gene

No data available for DME Specific Peptides for C8orf74 Gene

Domains & Families for C8orf74 Gene

Gene Families for C8orf74 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf74 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf74: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf74 Gene

Function for C8orf74 Gene

Phenotypes From GWAS Catalog for C8orf74 Gene

Gene Ontology (GO) - Molecular Function for C8orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with C8orf74: view
genes like me logo Genes that share phenotypes with C8orf74: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf74 Gene

Localization for C8orf74 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf74 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf74 Gene

Pathways & Interactions for C8orf74 Gene

SuperPathways for C8orf74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C8orf74 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf74 Gene

Drugs & Compounds for C8orf74 Gene

No Compound Related Data Available

Transcripts for C8orf74 Gene

mRNA/cDNA for C8orf74 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf74 Gene

Chromosome 8 open reading frame 74:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf74 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - -
SP4: - -

Relevant External Links for C8orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf74 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf74 Gene

This gene is overexpressed in Testis (x47.1).

Protein differential expression in normal tissues from HIPED for C8orf74 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf74 Gene

Protein tissue co-expression partners for C8orf74 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C8orf74 Gene:


SOURCE GeneReport for Unigene cluster for C8orf74 Gene:

genes like me logo Genes that share expression patterns with C8orf74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf74 Gene

Orthologs for C8orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C8H8orf74 33
  • 97.72 (n)
C8orf74 34
  • 96 (a)
(Bos Taurus)
Mammalia C8H8orf74 33
  • 81.48 (n)
C8orf74 34
  • 74 (a)
(Canis familiaris)
Mammalia C25H8orf74 33
  • 81.48 (n)
C8orf74 34
  • 76 (a)
(Rattus norvegicus)
Mammalia RGD1565212 33
  • 76.64 (n)
(Mus musculus)
Mammalia 4930578I06Rik 16 34 33
  • 74.94 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia C8orf74 34
  • 44 (a)
(Anolis carolinensis)
Reptilia C8orf74 34
  • 40 (a)
(Danio rerio)
Actinopterygii LOC100330335 33
  • 45.18 (n)
C17H8orf74 34
  • 25 (a)
Species where no ortholog for C8orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf74 Gene

Gene Tree for C8orf74 (if available)
Gene Tree for C8orf74 (if available)

Paralogs for C8orf74 Gene

No data available for Paralogs for C8orf74 Gene

Variants for C8orf74 Gene

Sequence variations from dbSNP and Humsavar for C8orf74 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000113972 -- 10,688,627(+) G/C intron_variant
rs1000117924 -- 10,677,608(+) C/A/T intron_variant
rs1000118517 -- 10,683,032(+) G/A/C intron_variant
rs1000132404 -- 10,673,898(+) T/C intron_variant
rs1000192106 -- 10,677,371(+) C/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf74 Gene

Variant ID Type Subtype PubMed ID
dgv11953n54 CNV loss 21841781
dgv865n27 CNV loss 19166990
esv990685 CNV deletion 20482838
nsv1025557 CNV gain 25217958
nsv1030934 CNV gain 25217958
nsv398183 CNV deletion 16902084
nsv515898 CNV loss 19592680
nsv519236 CNV loss 19592680
nsv527184 CNV loss 19592680

Variation tolerance for C8orf74 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf74 Gene

Disorders for C8orf74 Gene

Additional Disease Information for C8orf74

No disorders were found for C8orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf74 Gene

Publications for C8orf74 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for C8orf74 Gene

Sources for C8orf74 Gene

Loading form....