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Aliases for C8orf59 Gene

Aliases for C8orf59 Gene

  • Chromosome 8 Open Reading Frame 59 2 3 5
  • Uncharacterized Protein C8orf59 3

External Ids for C8orf59 Gene

Previous GeneCards Identifiers for C8orf59 Gene

  • GC08M086314
  • GC08M086126
  • GC08M081620

Summaries for C8orf59 Gene

GeneCards Summary for C8orf59 Gene

C8orf59 (Chromosome 8 Open Reading Frame 59) is a Protein Coding gene.

Additional gene information for C8orf59 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf59 Gene

Genomics for C8orf59 Gene

GeneHancer (GH) Regulatory Elements for C8orf59 Gene

Promoters and enhancers for C8orf59 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J085219 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.8 -803 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CA13 C8orf59 LRRCC1 E2F5 ENSG00000258256 LOC105375936
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8orf59 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf59 gene promoter:
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • FOXL1
  • STAT5B
  • FOXO4
  • LUN-1

Genomic Locations for C8orf59 Gene

Genomic Locations for C8orf59 Gene
6,370 bases
Minus strand
6,363 bases
Minus strand

Genomic View for C8orf59 Gene

Genes around C8orf59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf59 Gene

Proteins for C8orf59 Gene

  • Protein details for C8orf59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf59
    Protein Accession:
    Secondary Accessions:
    • B2RXE7
    • E5RFW5

    Protein attributes for C8orf59 Gene

    100 amino acids
    Molecular mass:
    11456 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf59 Gene


neXtProt entry for C8orf59 Gene

Post-translational modifications for C8orf59 Gene

  • Ubiquitination at posLast=2121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C8orf59 Gene

Domains & Families for C8orf59 Gene

Gene Families for C8orf59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf59 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf59: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf59 Gene

Function for C8orf59 Gene

genes like me logo Genes that share phenotypes with C8orf59: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf59 Gene

Localization for C8orf59 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf59 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf59 Gene

Pathways & Interactions for C8orf59 Gene

SuperPathways for C8orf59 Gene

No Data Available

Interacting Proteins for C8orf59 Gene

Selected Interacting proteins: Q8N0T1-CH059_HUMAN for C8orf59 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C8orf59 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf59 Gene

Drugs & Compounds for C8orf59 Gene

No Compound Related Data Available

Transcripts for C8orf59 Gene

Unigene Clusters for C8orf59 Gene

Chromosome 8 open reading frame 59:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf59 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3
SP1: -
SP2: - -
SP3: -

Relevant External Links for C8orf59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C8orf59 Gene

This gene is overexpressed in Breast (42.7) and Bone (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C8orf59 Gene

Protein tissue co-expression partners for C8orf59 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf59 Gene:


SOURCE GeneReport for Unigene cluster for C8orf59 Gene:

genes like me logo Genes that share expression patterns with C8orf59: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf59 Gene

Orthologs for C8orf59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf59 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C8H8orf59 33
  • 100 (n)
C8orf59 34
  • 98 (a)
(Canis familiaris)
Mammalia C29H8orf59 33
  • 91.67 (n)
(Bos Taurus)
Mammalia C14H8orf59 33
  • 90.33 (n)
-- 34
  • 81 (a)
-- 34
  • 81 (a)
-- 34
  • 77 (a)
(Mus musculus)
Mammalia 1810022K09Rik 16 34 33
  • 85.91 (n)
Gm4540 34
  • 76 (a)
(Rattus norvegicus)
Mammalia RGD1565641 33
  • 84.54 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
(Danio rerio)
Actinopterygii C24H8orf59 34
  • 36 (a)
Species where no ortholog for C8orf59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf59 Gene

Gene Tree for C8orf59 (if available)
Gene Tree for C8orf59 (if available)

Paralogs for C8orf59 Gene

genes like me logo Genes that share paralogs with C8orf59: view

No data available for Paralogs for C8orf59 Gene

Variants for C8orf59 Gene

Sequence variations from dbSNP and Humsavar for C8orf59 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000821031 -- 85,216,540(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000883433 -- 85,218,555(-) T/C intron_variant
rs1000958143 -- 85,217,000(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001461416 -- 85,218,136(-) T/C intron_variant
rs1001661096 -- 85,221,840(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf59 Gene

Variant ID Type Subtype PubMed ID
nsv483126 CNV gain+loss 15286789

Variation tolerance for C8orf59 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf59 Gene

Disorders for C8orf59 Gene

Additional Disease Information for C8orf59

No disorders were found for C8orf59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf59 Gene

Publications for C8orf59 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A … Levine B (Nature 2011) 3 58

Products for C8orf59 Gene

Sources for C8orf59 Gene

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