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Aliases for C8orf58 Gene

Aliases for C8orf58 Gene

  • Chromosome 8 Open Reading Frame 58 2 3 5
  • Uncharacterized Protein C8orf58 3 4

External Ids for C8orf58 Gene

Previous GeneCards Identifiers for C8orf58 Gene

  • GC08U900616
  • GC08P022513
  • GC08P022446
  • GC08P022457
  • GC08P020999

Summaries for C8orf58 Gene

GeneCards Summary for C8orf58 Gene

C8orf58 (Chromosome 8 Open Reading Frame 58) is a Protein Coding gene. An important paralog of this gene is ENSG00000248235.

Additional gene information for C8orf58 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf58 Gene

Genomics for C8orf58 Gene

GeneHancer (GH) Regulatory Elements for C8orf58 Gene

Promoters and enhancers for C8orf58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022593 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 645.3 -1.6 -1647 8.5 ZFX ELF3 SP1 CTCF ZNF148 NKRF ZNF121 MAFK ZBTB7A YY1 C8orf58 PDLIM2 ENSG00000248235
GH08J022603 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 77.7 +5.4 5409 3.6 MTA3 ZNF652 ZFX SP1 CC2D1A ELF3 MNT SIX5 ZNF148 NKRF CCAR2 PIR42411 PIR62346 PIR54985 GC08P022605 C8orf58 ENSG00000253200 FAM160B2 BMP1 POLR3D
GH08J022691 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.3 +94.5 94502 5.8 ZFX ZNF148 NKRF GTF2F1 ZNF687 ZSCAN21 ZBTB7A YY1 SP7 ZNF548 EGR3 LOC105379322 LOC105379321 FAM160B2 ENSG00000253200 LOXL2 BMP1 ENSG00000245025 C8orf58 SORBS3
GH08J022578 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.5 -14.9 -14890 13.1 ELF3 CTCF ZNF148 CEBPG AHR MAFK TFE3 SP7 POLR2A SP1 PDLIM2 C8orf58 CCAR2 ENSG00000253200 BIN3 FGF17 ENSG00000248235
GH08J022666 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 40.2 +68.8 68769 3.3 ZNF652 SP1 ZFX ELF3 CBFA2T2 ZNF148 NKRF POLR2A MLLT1 GTF2F1 BIN3 C8orf58 POLR3D LOC105369180 GC08P022638
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8orf58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf58 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • E47
  • ITF-2
  • Lmo2
  • Spz1
  • Tal-1beta
  • Zic3

Genomic Locations for C8orf58 Gene

Genomic Locations for C8orf58 Gene
4,552 bases
Plus strand
4,550 bases
Plus strand

Genomic View for C8orf58 Gene

Genes around C8orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf58 Gene

Proteins for C8orf58 Gene

  • Protein details for C8orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf58
    Protein Accession:
    Secondary Accessions:
    • B4DI44

    Protein attributes for C8orf58 Gene

    365 amino acids
    Molecular mass:
    39661 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf58 Gene


neXtProt entry for C8orf58 Gene

Post-translational modifications for C8orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf58 Gene

No data available for DME Specific Peptides for C8orf58 Gene

Domains & Families for C8orf58 Gene

Gene Families for C8orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf58 Gene


Suggested Antigen Peptide Sequences for C8orf58 Gene

GenScript: Design optimal peptide antigens:
  • C8orf58 protein (Q7Z758_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf58: view

No data available for UniProtKB/Swiss-Prot for C8orf58 Gene

Function for C8orf58 Gene

Phenotypes From GWAS Catalog for C8orf58 Gene

genes like me logo Genes that share phenotypes with C8orf58: view

Animal Models for C8orf58 Gene

MGI Knock Outs for C8orf58:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for C8orf58 - Now 50% OFF >
  • * C8orf58 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C8orf58 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C8orf58 Gene

Localization for C8orf58 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C8orf58 Gene

Pathways & Interactions for C8orf58 Gene

PathCards logo

SuperPathways for C8orf58 Gene

No Data Available

Interacting Proteins for C8orf58 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
Selected Interacting proteins: ENSP00000289989 for C8orf58 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C8orf58 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf58 Gene

Drugs & Compounds for C8orf58 Gene

No Compound Related Data Available

Transcripts for C8orf58 Gene

mRNA/cDNA for C8orf58 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for C8orf58 Gene

Chromosome 8 open reading frame 58:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for C8orf58 - Now 50% OFF >
  • * C8orf58 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C8orf58 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf58 Gene

No ASD Table

Relevant External Links for C8orf58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf58 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf58 Gene

Protein tissue co-expression partners for C8orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C8orf58 Gene:


SOURCE GeneReport for Unigene cluster for C8orf58 Gene:

genes like me logo Genes that share expression patterns with C8orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf58 Gene

Orthologs for C8orf58 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C8orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia C25H8orf58 34
  • 78.66 (n)
-- 35
  • 63 (a)
(Bos Taurus)
Mammalia C8H8orf58 34
  • 75.72 (n)
-- 35
  • 57 (a)
(Rattus norvegicus)
Mammalia RGD1308117 34
  • 74.14 (n)
(Mus musculus)
Mammalia 9930012K11Rik 34 35 17
  • 74.12 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
Species where no ortholog for C8orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf58 Gene

Gene Tree for C8orf58 (if available)
Gene Tree for C8orf58 (if available)

Paralogs for C8orf58 Gene

Paralogs for C8orf58 Gene

genes like me logo Genes that share paralogs with C8orf58: view

Variants for C8orf58 Gene

Sequence variations from dbSNP and Humsavar for C8orf58 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000000258 -- 22,600,185(+) C/A/T intron_variant
rs1000502330 -- 22,599,997(+) C/T intron_variant
rs1001423549 -- 22,600,611(+) T/C/G intron_variant
rs1002575859 -- 22,598,206(+) G/A/T upstream_transcript_variant
rs1002628381 -- 22,598,405(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf58 Gene

Variant ID Type Subtype PubMed ID
esv2759604 CNV loss 17122850
nsv1077027 CNV deletion 25765185

Variation tolerance for C8orf58 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf58 Gene

Disorders for C8orf58 Gene

Additional Disease Information for C8orf58

No disorders were found for C8orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf58 Gene

Publications for C8orf58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C8orf58 Gene

Sources for C8orf58 Gene

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