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C8orf58 Gene(Protein Coding)

Chromosome 8 Open Reading Frame 58

GCID:
GC08P022599
GIFtS:
34
Genes Participants
UDN Logo

Aliases for C8orf58 Gene

Aliases for C8orf58 Gene

  • Chromosome 8 Open Reading Frame 58 2 3 5

External Ids for C8orf58 Gene

Previous GeneCards Identifiers for C8orf58 Gene

  • GC08U900616
  • GC08P022513
  • GC08P022446
  • GC08P022457
  • GC08P020999

Summaries for C8orf58 Gene

GeneCards Summary for C8orf58 Gene

C8orf58 (Chromosome 8 Open Reading Frame 58) is a Protein Coding gene. An important paralog of this gene is ENSG00000248235.

Additional gene information for C8orf58 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf58 Gene

Genomics for C8orf58 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for C8orf58 Gene

Promoters and enhancers for C8orf58 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I022593 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 595.4 -1.6 -1649 8.5 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 FOS C8orf58 ENSG00000248235 PDLIM2
GH08I022603 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 80.5 +5.4 5407 3.6 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC CCAR2 GC08P022605 PIR54985 PIR42411 PIR62346 C8orf58 ENSG00000253200 FAM160B2 ENTPD4 BIN3
GH08I022578 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.5 -14.9 -14892 13.1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF143 FOS PDLIM2 C8orf58 CCAR2 ENSG00000253200 BIN3 FGF17 ENSG00000248235
GH08I022666 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 40.2 +68.8 68754 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 IRF4 SLC30A9 POLR2B E2F8 BIN3 C8orf58 POLR3D LOC105369180 GC08P022638
GH08I023159 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29 +562.8 562788 5.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNFRSF10D ENSG00000253200 ENTPD4 C8orf58 POLR3D CCAR2 BIN3 CHMP7 TNFRSF10A LOC389641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C8orf58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf58 gene promoter:

Genomic Locations for C8orf58 Gene

Genomic Locations for C8orf58 Gene
chr8:22,599,601-22,604,150
(GRCh38/hg38)
Size:
4,550 bases
Orientation:
Plus strand
chr8:22,457,114-22,461,663
(GRCh37/hg19)

Genomic View for C8orf58 Gene

Genes around C8orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf58 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C8orf58 Gene

Proteins for C8orf58 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for C8orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAV2-CH058_HUMAN
    Recommended name:
    Uncharacterized protein C8orf58
    Protein Accession:
    Q8NAV2
    Secondary Accessions:
    • B4DI44

    Protein attributes for C8orf58 Gene

    Size:
    365 amino acids
    Molecular mass:
    39661 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf58 Gene

Protein Expression for C8orf58 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C8orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf58 Gene

Domains & Families for C8orf58 Gene

Gene Families for C8orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf58: view

No data available for UniProtKB/Swiss-Prot for C8orf58 Gene

Function for C8orf58 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for C8orf58 Gene

genes like me logo Genes that share phenotypes with C8orf58: view

Animal Models for C8orf58 Gene

MGI Knock Outs for C8orf58:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C8orf58 Gene

Localization for C8orf58 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C8orf58 Gene

Pathways & Interactions for C8orf58 Gene

SuperPathways for C8orf58 Gene

PathCards logo More details on SuperPathways for C8orf58
No Data Available

Interacting Proteins for C8orf58 Gene

Gene Ontology (GO) - Biological Process for C8orf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf58 Gene

Drugs & Compounds for C8orf58 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for C8orf58 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for C8orf58 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf58 Gene

Chromosome 8 open reading frame 58:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf58 Gene

No ASD Table

Relevant External Links for C8orf58 Gene

GeneLoc Exon Structure for
C8orf58
ECgene alternative splicing isoforms for
C8orf58

Expression for C8orf58 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf58 Gene

mRNA expression in normal human tissues for C8orf58 Gene
mRNA expression by GTEx for C8orf58 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf58 Gene



Protein tissue co-expression partners for C8orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C8orf58 Gene:

C8orf58

SOURCE GeneReport for Unigene cluster for C8orf58 Gene:

Hs.743508
genes like me logo Genes that share expression patterns with C8orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf58 Gene

Orthologs for C8orf58 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C8orf58 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia C25H8orf58 33
  • 78.66 (n)
-- 34
  • 63 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia C8H8orf58 33
  • 75.72 (n)
-- 34
  • 57 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia RGD1308117 33
  • 74.14 (n)
mouse
(Mus musculus)
 Mammalia 9930012K11Rik 33 16 34
  • 74.12 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 40 (a)
 OneToMany
Species where no ortholog for C8orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf58 Gene

ENSEMBL:
Gene Tree for C8orf58 (if available)
TreeFam:
Gene Tree for C8orf58 (if available)

Paralogs for C8orf58 Gene

Paralogs for C8orf58 Gene

genes like me logo Genes that share paralogs with C8orf58: view

Variants for C8orf58 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for C8orf58 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000000258 -- 22,600,185(+) C/A intron_variant
rs1000502330 -- 22,599,997(+) C/T intron_variant
rs1001423549 -- 22,600,611(+) T/C/G intron_variant
rs1002575859 -- 22,598,206(+) G/A/T upstream_transcript_variant
rs1002628381 -- 22,598,405(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf58 Gene

Variant ID Type Subtype PubMed ID
esv2759604 CNV loss 17122850
nsv1077027 CNV deletion 25765185

Variation tolerance for C8orf58 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf58 Gene

Disorders for C8orf58 Gene

Additional Disease Information for C8orf58

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C8orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf58 Gene

Publications for C8orf58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C8orf58 Gene

Sources for C8orf58 Gene

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