Aliases for C8orf58 Gene
External Ids for C8orf58 Gene
- HGNC: 32233
- Entrez Gene: 541565
- Ensembl: ENSG00000241852
- UniProtKB: Q8NAV2
Previous GeneCards Identifiers for C8orf58 Gene
- GC08U900616
- GC08P022513
- GC08P022446
- GC08P022457
- GC08P020999
Summaries for C8orf58 Gene
GeneCards Summary for C8orf58 Gene
C8orf58 (Chromosome 8 Open Reading Frame 58) is a Protein Coding gene. An important paralog of this gene is ENSG00000248235.
Additional gene information for C8orf58 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf58 Gene
Genomics for C8orf58 Gene
GeneHancer (GH) Regulatory Elements for C8orf58 Gene
Promoters and enhancers for C8orf58 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around C8orf58 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for C8orf58 Gene
Genomic Locations for C8orf58 Gene
- chr8:22,599,601-22,604,150
- (GRCh38/hg38)
- Size:
- 4,550 bases
- Orientation:
- Plus strand
- chr8:22,457,114-22,461,663
- (GRCh37/hg19)
Genomic View for C8orf58 Gene
Genes around C8orf58 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by Entrez Gene
- 8p21.3 by HGNC
- 8p21.3 by Ensembl
C8orf58 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C8orf58 Gene
Proteins for C8orf58 Gene
-
Protein details for C8orf58 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NAV2-CH058_HUMAN
- Recommended name:
- Uncharacterized protein C8orf58
- Protein Accession:
- Q8NAV2
- B4DI44
Protein attributes for C8orf58 Gene
- Size:
- 365 amino acids
- Molecular mass:
- 39661 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC03795.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for C8orf58 Gene
Post-translational modifications for C8orf58 Gene
Other Protein References for C8orf58 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C8orf58
- Invitrogen Antibodies for C8orf58
- Search GeneTex for Antibodies for C8orf58
-
Boster Bio Antibodies for C8orf58
Protein Products
-
OriGene Purified Proteins for C8orf58
- Search Origene for MassSpec and Protein Over-expression Lysates for C8orf58
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- Search GeneTex for Proteins for C8orf58
Assay Products
No data available for DME Specific Peptides for C8orf58 Gene
Domains & Families for C8orf58 Gene
Gene Families for C8orf58 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for C8orf58 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for C8orf58 Gene
Function for C8orf58 Gene
Phenotypes From GWAS Catalog for C8orf58 Gene
Phenotypes for C8orf58 Gene
- MGI mutant phenotypes for C8orf58:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for C8orf58:
Animal Models for C8orf58 Gene
- MGI Knock Outs for C8orf58:
-
- 9930012K11Rik 9930012K11Rik<tm2b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C8orf58
-
CRISPR Products
-
OriGene CRISPR knockouts for C8orf58
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- genomics-online: gRNA clones - Search results for 46 available C8ORF58 gene related products
- Overview of 46 available C8ORF58 gene related products
- Applied Biological Materials CRISPR for C8orf58
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C8orf58
- GenScript: Design CRISPR guide RNA sequences for C8orf58
miRNA for C8orf58 Gene
- miRTarBase miRNAs that target C8orf58
-
- hsa-mir-4752 (MIRT480240)
- hsa-mir-6833-5p (MIRT480241)
- hsa-mir-6079 (MIRT480242)
- hsa-mir-3190-3p (MIRT480243)
- hsa-mir-671-5p (MIRT480244)
- hsa-mir-6828-5p (MIRT480245)
- hsa-mir-4765 (MIRT480246)
- hsa-mir-1236-5p (MIRT480247)
- hsa-mir-7978 (MIRT480248)
- hsa-mir-4456 (MIRT480249)
- hsa-mir-548q (MIRT480250)
- hsa-mir-4299 (MIRT480251)
- hsa-mir-6764-5p (MIRT480252)
- hsa-mir-1915-3p (MIRT480253)
- hsa-mir-7113-5p (MIRT480254)
- hsa-mir-4289 (MIRT480255)
- hsa-mir-3174 (MIRT480256)
- hsa-mir-130a-5p (MIRT480257)
- hsa-mir-23c (MIRT480258)
- hsa-mir-23b-3p (MIRT480259)
- hsa-mir-23a-3p (MIRT480260)
- hsa-mir-3167 (MIRT480261)
- hsa-mir-876-5p (MIRT480262)
- hsa-mir-24-3p (MIRT739222)
- hsa-mir-3125 (MIRT739998)
- hsa-mir-3170 (MIRT740594)
- hsa-mir-380-5p (MIRT742786)
- hsa-mir-4284 (MIRT743725)
- hsa-mir-4474-3p (MIRT745005)
- hsa-mir-5572 (MIRT750906)
- hsa-mir-563 (MIRT751104)
- hsa-mir-615-5p (MIRT752484)
- hsa-mir-6730-5p (MIRT753971)
- hsa-mir-6737-5p (MIRT754228)
- hsa-mir-6812-5p (MIRT756697)
- hsa-mir-6819-5p (MIRT756844)
- hsa-mir-6855-5p (MIRT757685)
- hsa-mir-7704 (MIRT759726)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C8orf58
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C8orf58
- genomics-online: shRNA clones - Search results for 46 available C8ORF58 gene related products
- Overview of 46 available C8ORF58 gene related products
Clone Products
-
OriGene ORF clones in human for C8orf58
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for C8orf58
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf58
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C8orf58
- Applied Biological Materials Clones for C8orf58
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for C8orf58
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C8orf58 Gene
Localization for C8orf58 Gene
- Nuclear bodies (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C8orf58 Gene
Transcripts for C8orf58 Gene
mRNA/cDNA for C8orf58 Gene
- (3) Additional mRNA sequences :
- (3) REFSEQ mRNAs :
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000289989 2016 bps (uc003xce.4)
- ENST00000409586 2021 bps (uc011kzl.3)
- ENST00000453427 953 bps (uc064lbj.1)
- ENST00000475994 448 bps (uc064lbl.1)
- ENST00000495957 807 bps (uc064lbm.1)
Unigene Clusters for C8orf58 Gene
- Chromosome 8 open reading frame 58:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for C8orf58
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C8orf58
- genomics-online: gRNA clones - Search results for 46 available C8ORF58 gene related products
- Overview of 46 available C8ORF58 gene related products
- Applied Biological Materials CRISPR for C8orf58
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C8orf58
- GenScript: Design CRISPR guide RNA sequences for C8orf58
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C8orf58
- Browse OriGene Inhibitory RNA Products For C8orf58
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C8orf58
- genomics-online: shRNA clones - Search results for 46 available C8ORF58 gene related products
- Overview of 46 available C8ORF58 gene related products
Clone Products
-
OriGene ORF clones in human for C8orf58
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for C8orf58
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf58
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C8orf58
- Applied Biological Materials Clones for C8orf58
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for C8orf58 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf58 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C8orf58 Gene:
C8orf58SOURCE GeneReport for Unigene cluster for C8orf58 Gene:
Hs.743508Primer Products
-
OriGene qPCR primer pairs and template standards for C8orf58
-
OriGene qPCR primer pairs for C8orf58
- genomics-online: primer clones - Search results for 46 available C8ORF58 gene related products
- Overview of 46 available C8ORF58 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf58 Gene
Orthologs for C8orf58 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | C25H8orf58 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | C8H8orf58 33 |
|
||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | RGD1308117 33 |
|
||
| mouse (Mus musculus) |
Mammalia | 9930012K11Rik 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany |
- Species where no ortholog for C8orf58 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C8orf58 Gene
Paralogs for C8orf58 Gene
Variants for C8orf58 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000258 | -- | 22,600,185(+) | C/A | intron_variant | |
| rs1000502330 | -- | 22,599,997(+) | C/T | intron_variant | |
| rs1001423549 | -- | 22,600,611(+) | T/C/G | intron_variant | |
| rs1002575859 | -- | 22,598,206(+) | G/A/T | upstream_transcript_variant | |
| rs1002628381 | -- | 22,598,405(+) | G/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759604 | CNV | loss | 17122850 |
| nsv1077027 | CNV | deletion | 25765185 |
Residual Variation Intolerance Score:
87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.64;
45.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C8orf58 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C8orf58
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf58 Gene
Disorders for C8orf58 Gene
Additional Disease Information for C8orf58
No disorders were found for C8orf58 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf58 Gene
Publications for C8orf58 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
- A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for C8orf58 Gene
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- OriGene Purified Proteins for C8orf58
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- OriGene qPCR primer pairs and template standards for C8orf58
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- VectorBuilder custom plasmid, inducible vectors for C8orf58
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf58
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for C8orf58
- Search GeneTex for Proteins for C8orf58
- Horizon Cell Lines for C8orf58
- genomics-online: cdna clones - Search results for 46 available C8ORF58 gene related products
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- Overview of 46 available C8ORF58 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C8orf58
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Sources for C8orf58 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio