Aliases for C8orf58 Gene

Aliases for C8orf58 Gene

  • Chromosome 8 Open Reading Frame 58 2 3 5
  • Uncharacterized Protein C8orf58 3 4
  • FLJ34715 2
  • C8orf58 5

External Ids for C8orf58 Gene

Previous GeneCards Identifiers for C8orf58 Gene

  • GC08U900616
  • GC08P022513
  • GC08P022446
  • GC08P022457
  • GC08P020999

Summaries for C8orf58 Gene

GeneCards Summary for C8orf58 Gene

C8orf58 (Chromosome 8 Open Reading Frame 58) is a Protein Coding gene. An important paralog of this gene is ENSG00000248235.

Additional gene information for C8orf58 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C8orf58 Gene

Genomics for C8orf58 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C8orf58 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8orf58 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C8orf58

Top Transcription factor binding sites by QIAGEN in the C8orf58 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • E47
  • ITF-2
  • Lmo2
  • Spz1
  • Tal-1beta
  • Zic3

Genomic Locations for C8orf58 Gene

Genomic Locations for C8orf58 Gene
4,552 bases
Plus strand
4,550 bases
Plus strand

Genomic View for C8orf58 Gene

Genes around C8orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf58 Gene

Proteins for C8orf58 Gene

  • Protein details for C8orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf58
    Protein Accession:
    Secondary Accessions:
    • B4DI44

    Protein attributes for C8orf58 Gene

    365 amino acids
    Molecular mass:
    39661 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf58 Gene


neXtProt entry for C8orf58 Gene

Post-translational modifications for C8orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf58 Gene

No data available for DME Specific Peptides for C8orf58 Gene

Domains & Families for C8orf58 Gene

Gene Families for C8orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf58 Gene


Suggested Antigen Peptide Sequences for C8orf58 Gene

GenScript: Design optimal peptide antigens:
  • C8orf58 protein (Q7Z758_HUMAN)
genes like me logo Genes that share domains with C8orf58: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C8orf58 Gene

Function for C8orf58 Gene

Phenotypes From GWAS Catalog for C8orf58 Gene

genes like me logo Genes that share phenotypes with C8orf58: view

Animal Models for C8orf58 Gene

MGI Knock Outs for C8orf58:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C8orf58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C8orf58 Gene

Localization for C8orf58 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C8orf58 Gene

Pathways & Interactions for C8orf58 Gene

PathCards logo

SuperPathways for C8orf58 Gene

No Data Available

Interacting Proteins for C8orf58 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000289989 for C8orf58 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C8orf58 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf58 Gene

Drugs & Compounds for C8orf58 Gene

No Compound Related Data Available

Transcripts for C8orf58 Gene

mRNA/cDNA for C8orf58 Gene

7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C8orf58

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf58 Gene

No ASD Table

Relevant External Links for C8orf58 Gene

GeneLoc Exon Structure for

Expression for C8orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C8orf58 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf58 Gene

Protein tissue co-expression partners for C8orf58 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C8orf58

SOURCE GeneReport for Unigene cluster for C8orf58 Gene:

genes like me logo Genes that share expression patterns with C8orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf58 Gene

Orthologs for C8orf58 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C8orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia C25H8orf58 30
  • 78.66 (n)
-- 31
  • 63 (a)
(Bos Taurus)
Mammalia C8H8orf58 30
  • 75.72 (n)
-- 31
  • 57 (a)
(Rattus norvegicus)
Mammalia RGD1308117 30
  • 74.14 (n)
(Mus musculus)
Mammalia 9930012K11Rik 30 17 31
  • 74.12 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 40 (a)
Species where no ortholog for C8orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C8orf58 Gene

Gene Tree for C8orf58 (if available)
Gene Tree for C8orf58 (if available)

Paralogs for C8orf58 Gene

Paralogs for C8orf58 Gene

genes like me logo Genes that share paralogs with C8orf58: view

Variants for C8orf58 Gene

Additional dbSNP identifiers (rs#s) for C8orf58 Gene

Structural Variations from Database of Genomic Variants (DGV) for C8orf58 Gene

Variant ID Type Subtype PubMed ID
esv2759604 CNV loss 17122850
nsv1077027 CNV deletion 25765185

Variation tolerance for C8orf58 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C8orf58 Gene

Disorders for C8orf58 Gene

No disorders were found for C8orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf58 Gene

Publications for C8orf58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3

Products for C8orf58 Gene

Sources for C8orf58 Gene