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Aliases for C8orf44 Gene

Aliases for C8orf44 Gene

  • Chromosome 8 Open Reading Frame 44 2 3 5
  • Putative Uncharacterized Protein C8orf44 3

External Ids for C8orf44 Gene

Previous GeneCards Identifiers for C8orf44 Gene

  • GC08P067743
  • GC08P067588
  • GC08P063080

Summaries for C8orf44 Gene

GeneCards Summary for C8orf44 Gene

C8orf44 (Chromosome 8 Open Reading Frame 44) is a Protein Coding gene.

Additional gene information for C8orf44 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf44 Gene

Genomics for C8orf44 Gene

GeneHancer (GH) Regulatory Elements for C8orf44 Gene

Promoters and enhancers for C8orf44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J066663 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 655.3 -1.4 -1354 6.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 C8orf44 VCPIP1 SGK3 C8orf44-SGK3 ARFGEF1 MYBL1 VXN ENSG00000201365
GH08J066112 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 21.6 -553.4 -553372 3.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 TRIM55 PIR59286 PIR37716 TRY-GTA5-2 TRY-GTA5-1 GC08P066152 GC08P066148 C8orf44 CSPP1 MCMDC2
GH08J066605 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 14.4 -57.2 -57175 8.8 PKNOX1 ARNT ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF213 ZNF143 SP3 MYBL1 ARFGEF1 C8orf44 ADHFE1 RRS1-AS1 RRS1 VXN VCPIP1 LOC105375884 GC08M066613
GH08J067060 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.1 +395.9 395929 5.4 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 CSPP1 COPS5 ARFGEF1 C8orf44 TCF24
GH08J066922 Promoter/Enhancer 1.6 Ensembl ENCODE 20.4 +257.1 257053 5.1 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 SNHG6 ARFGEF1 C8orf44 CSPP1 TCF24 VCPIP1 SNORD87 GC08M066924 GC08M066923 MCMDC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C8orf44 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf44 gene promoter:

Genomic Locations for C8orf44 Gene

Genomic Locations for C8orf44 Gene
chr8:66,667,552-66,685,564
(GRCh38/hg38)
Size:
18,013 bases
Orientation:
Plus strand
chr8:67,579,787-67,597,799
(GRCh37/hg19)

Genomic View for C8orf44 Gene

Genes around C8orf44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf44 Gene

Proteins for C8orf44 Gene

  • Protein details for C8orf44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CB5-CH044_HUMAN
    Recommended name:
    Putative uncharacterized protein C8orf44
    Protein Accession:
    Q96CB5
    Secondary Accessions:
    • Q9NUM6

    Protein attributes for C8orf44 Gene

    Size:
    159 amino acids
    Molecular mass:
    18380 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C8orf44 Gene

Post-translational modifications for C8orf44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf44 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf44 Gene

Domains & Families for C8orf44 Gene

Gene Families for C8orf44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf44 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf44: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf44 Gene

Function for C8orf44 Gene

genes like me logo Genes that share phenotypes with C8orf44: view

Animal Model Products

miRNA for C8orf44 Gene

miRTarBase miRNAs that target C8orf44

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf44 Gene

Localization for C8orf44 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf44 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C8orf44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with C8orf44: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C8orf44 Gene

Pathways & Interactions for C8orf44 Gene

SuperPathways for C8orf44 Gene

No Data Available

Interacting Proteins for C8orf44 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000375087%0d%0a9606.ENSP00000281708%0d%0a
Selected Interacting proteins: ENSP00000375087 for C8orf44 Gene via STRING

Symbol External ID(s) Details
FBXW7

Gene Ontology (GO) - Biological Process for C8orf44 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf44 Gene

Drugs & Compounds for C8orf44 Gene

No Compound Related Data Available

Transcripts for C8orf44 Gene

mRNA/cDNA for C8orf44 Gene

(139) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf44 Gene

Chromosome 8 open reading frame 44:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf44 Gene

No ASD Table

Relevant External Links for C8orf44 Gene

GeneLoc Exon Structure for
C8orf44
ECgene alternative splicing isoforms for
C8orf44

Expression for C8orf44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf44 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf44 Gene:

C8orf44

SOURCE GeneReport for Unigene cluster for C8orf44 Gene:

Hs.661238

Evidence on tissue expression from TISSUES for C8orf44 Gene

  • Pancreas(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with C8orf44: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf44 Gene

Orthologs for C8orf44 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C8orf44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf44 33
  • 98.31 (n)
C8orf44 34
  • 96 (a)
OneToOne
Species where no ortholog for C8orf44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf44 Gene

ENSEMBL:
Gene Tree for C8orf44 (if available)
TreeFam:
Gene Tree for C8orf44 (if available)

Paralogs for C8orf44 Gene

(16) SIMAP similar genes for C8orf44 Gene using alignment to 2 proteins:

  • CH044_HUMAN
  • E5RJQ3_HUMAN
genes like me logo Genes that share paralogs with C8orf44: view

No data available for Paralogs for C8orf44 Gene

Variants for C8orf44 Gene

Sequence variations from dbSNP and Humsavar for C8orf44 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000502119 -- 66,670,640(+) T/C intron_variant
rs1000929109 -- 66,676,513(+) C/T intron_variant
rs1001054227 -- 66,670,253(+) C/T intron_variant
rs1001109555 -- 66,669,908(+) T/C intron_variant
rs1001458191 -- 66,676,806(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf44 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV loss 17160897

Variation tolerance for C8orf44 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf44 Gene

Disorders for C8orf44 Gene

Additional Disease Information for C8orf44

No disorders were found for C8orf44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf44 Gene

Publications for C8orf44 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for C8orf44 Gene

Sources for C8orf44 Gene

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