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Aliases for C8orf33 Gene

Aliases for C8orf33 Gene

  • Chromosome 8 Open Reading Frame 33 2 3 5
  • UPF0488 Protein C8orf33 3

External Ids for C8orf33 Gene

Previous GeneCards Identifiers for C8orf33 Gene

  • GC08P146249
  • GC08P141393

Summaries for C8orf33 Gene

GeneCards Summary for C8orf33 Gene

C8orf33 (Chromosome 8 Open Reading Frame 33) is a Protein Coding gene.

Additional gene information for C8orf33 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf33 Gene

Genomics for C8orf33 Gene

GeneHancer (GH) Regulatory Elements for C8orf33 Gene

Promoters and enhancers for C8orf33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J145051 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 661.2 +0.1 77 2.4 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 POLR2B C8orf33 GC08P145056 PIR53567 MAF1 ZNF252P SLC39A4 RPL8
GH08J145052 Promoter 0.7 Ensembl 658.9 -1.3 -1277 0.2 MITF FOSL1 IKZF1 C8orf33 LOC100419763
GH08J145000 Promoter/Enhancer 1.6 Ensembl ENCODE 21.1 -49.2 -49193 5 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF252P ZNF252P-AS1 VPS28 ADCK5 CPSF1 SLC52A2 COMMD5 ZNF7 ZNF16 C8orf33
GH08J145026 Enhancer 1 ENCODE 24.4 -25.0 -24988 1.2 FOXA2 ARID4B NEUROD1 SIN3A ZNF48 SLC30A9 TCF12 ELK1 ZNF143 NFKBIZ C8orf33 ZNF7 RPL8 GPAA1 LOC100419763 CPSF1 VPS28 ZNF16 ENSG00000254533 ZNF252P
GH08J144948 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 8 -102.2 -102179 2.6 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 ETS1 SLC30A9 ZNF16 ZNF7 CPSF1 VPS28 ADCK5 SLC52A2 COMMD5 LRRC14 GPAA1 ZNF252P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C8orf33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf33 gene promoter:

Genomic Locations for C8orf33 Gene

Genomic Locations for C8orf33 Gene
chr8:145,052,378-145,065,864
(GRCh38/hg38)
Size:
13,487 bases
Orientation:
Plus strand
chr8:146,277,764-146,281,416
(GRCh37/hg19)

Genomic View for C8orf33 Gene

Genes around C8orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf33 Gene

Proteins for C8orf33 Gene

  • Protein details for C8orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7E9-CH033_HUMAN
    Recommended name:
    UPF0488 protein C8orf33
    Protein Accession:
    Q9H7E9
    Secondary Accessions:
    • A6NGC0
    • Q96BT8

    Protein attributes for C8orf33 Gene

    Size:
    229 amino acids
    Molecular mass:
    24993 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf33 Gene

Post-translational modifications for C8orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf33 Gene

Domains & Families for C8orf33 Gene

Gene Families for C8orf33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7E9

UniProtKB/Swiss-Prot:

CH033_HUMAN :
  • Belongs to the UPF0488 family.
Family:
  • Belongs to the UPF0488 family.
genes like me logo Genes that share domains with C8orf33: view

Function for C8orf33 Gene

Gene Ontology (GO) - Molecular Function for C8orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19060904
genes like me logo Genes that share ontologies with C8orf33: view
genes like me logo Genes that share phenotypes with C8orf33: view

Animal Model Products

miRNA for C8orf33 Gene

miRTarBase miRNAs that target C8orf33

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf33 Gene

Localization for C8orf33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf33 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf33 Gene

Pathways & Interactions for C8orf33 Gene

SuperPathways for C8orf33 Gene

No Data Available

Interacting Proteins for C8orf33 Gene

Gene Ontology (GO) - Biological Process for C8orf33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf33 Gene

Drugs & Compounds for C8orf33 Gene

No Compound Related Data Available

Transcripts for C8orf33 Gene

mRNA/cDNA for C8orf33 Gene

Unigene Clusters for C8orf33 Gene

Chromosome 8 open reading frame 33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf33 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for C8orf33 Gene

GeneLoc Exon Structure for
C8orf33
ECgene alternative splicing isoforms for
C8orf33

Expression for C8orf33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf33 Gene

Protein differential expression in normal tissues from HIPED for C8orf33 Gene

This gene is overexpressed in Lung (29.3), Breast (16.2), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C8orf33 Gene



Protein tissue co-expression partners for C8orf33 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf33 Gene:

C8orf33

SOURCE GeneReport for Unigene cluster for C8orf33 Gene:

Hs.169615

Evidence on tissue expression from TISSUES for C8orf33 Gene

  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with C8orf33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf33 Gene

Orthologs for C8orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C8orf33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC464479 33
  • 97.67 (n)
C8orf33 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110038F14Rik 16 34 33
  • 81.7 (n)
dog
(Canis familiaris)
Mammalia C13H8orf33 33
  • 79.95 (n)
C8orf33 34
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C14H8orf33 33
  • 79.79 (n)
C8orf33 34
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681282 33
  • 72.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia C8orf33 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf33 34
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C24H8orf33 34
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14286 34
  • 23 (a)
OneToOne
Species where no ortholog for C8orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf33 Gene

ENSEMBL:
Gene Tree for C8orf33 (if available)
TreeFam:
Gene Tree for C8orf33 (if available)

Paralogs for C8orf33 Gene

Pseudogenes.org Pseudogenes for C8orf33 Gene

genes like me logo Genes that share paralogs with C8orf33: view

No data available for Paralogs for C8orf33 Gene

Variants for C8orf33 Gene

Sequence variations from dbSNP and Humsavar for C8orf33 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000149549 -- 145,050,923(+) TGTTTTTTTTTTTT/T upstream_transcript_variant
rs1001048733 -- 145,052,554(+) C/T intron_variant
rs1001143172 -- 145,052,164(+) C/T upstream_transcript_variant
rs1001192765 -- 145,053,208(+) C/T intron_variant
rs1001406776 -- 145,055,374(+) C/A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf33 Gene

Variant ID Type Subtype PubMed ID
dgv7338n100 CNV gain 25217958
dgv7339n100 CNV gain 25217958
dgv7340n100 CNV loss 25217958
dgv7341n100 CNV gain 25217958
dgv7342n100 CNV gain 25217958
esv2759653 CNV loss 17122850
esv2761199 CNV gain+loss 21179565
esv3619155 CNV loss 21293372
esv3619160 CNV loss 21293372
esv3619161 CNV gain 21293372
esv3891498 CNV gain 25118596
esv3891499 CNV gain 25118596
nsv1015720 CNV gain+loss 25217958
nsv1033208 CNV gain+loss 25217958
nsv466024 CNV gain 19166990
nsv466025 CNV gain 19166990
nsv508533 CNV deletion 20534489
nsv612974 CNV gain 21841781
nsv612978 CNV gain 21841781
nsv612980 CNV loss 21841781
nsv824811 CNV gain 20364138
nsv824812 CNV gain 20364138
nsv8399 CNV gain 18304495

Variation tolerance for C8orf33 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf33 Gene

Disorders for C8orf33 Gene

Additional Disease Information for C8orf33

No disorders were found for C8orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf33 Gene

Publications for C8orf33 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for C8orf33 Gene

Sources for C8orf33 Gene

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