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Aliases for C8orf17 Gene

Aliases for C8orf17 Gene

  • Chromosome 8 Open Reading Frame 17 2 3 5
  • MOLT-4 Sequence Tag-1 3
  • MOST-1 3
  • MOST1 3

External Ids for C8orf17 Gene

Previous GeneCards Identifiers for C8orf17 Gene

  • GC08P139904
  • GC08P141101
  • GC08P140627
  • GC08P140914
  • GC08P141012
  • GC08U901089

Summaries for C8orf17 Gene

GeneCards Summary for C8orf17 Gene

C8orf17 (Chromosome 8 Open Reading Frame 17) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C8orf17 Gene

  • May be involved in cell survival, proliferation and progression of cancer cells.

Additional gene information for C8orf17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf17 Gene

Genomics for C8orf17 Gene

GeneHancer (GH) Regulatory Elements for C8orf17 Gene

Promoters and enhancers for C8orf17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J140152 Enhancer 0.9 ENCODE 10.1 +222.7 222718 2.2 FOXA2 NFIB ARID4B ZNF48 RAD21 RARA ETS1 YY1 ZNF614 FOS KCNK9 C8orf17 GC08M140101 GC08P140241 TRAPPC9
GH08J140308 Enhancer 0.9 Ensembl ENCODE 9.5 +378.8 378774 2.1 MXI1 JUN MAX RAD21 RFX5 ZKSCAN1 FOSL1 SMC3 RCOR1 FOSL2 C8orf17 LOC105375779 GC08P140430 TRAPPC9
GH08J139969 Enhancer 0.7 ENCODE 11.5 +40.2 40154 4 TFAP4 FOXA2 SAP130 MLX MAX RAD21 RARA YY1 TEAD3 EGR1 C8orf17 KCNK9 GC08P140000 TRAPPC9
GH08J140105 Enhancer 0.7 ENCODE 10.4 +175.3 175258 1.8 ELF3 SOX5 SOX13 PKNOX1 FOXA2 SAP130 FOXA3 ELF1 ZNF384 RARA C8orf17 KCNK9 GC08M140101 GC08P140241 TRAPPC9
GH08J139956 Enhancer 0.6 ENCODE 12 +26.0 25950 1.1 RFX1 RXRA MAX REST BMI1 ETV5 RAD21 YY1 SP1 JUND C8orf17 GC08P140000 TRAPPC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8orf17 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C8orf17 Gene

Genomic Locations for C8orf17 Gene
2,775 bases
Plus strand
2,775 bases
Plus strand

Genomic View for C8orf17 Gene

Genes around C8orf17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for C8orf17 Gene

Proteins for C8orf17 Gene

  • Protein details for C8orf17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MOST-1
    Protein Accession:

    Protein attributes for C8orf17 Gene

    99 amino acids
    Molecular mass:
    11219 Da
    Quaternary structure:
    • Interacts with TSPO, IGHM and IGHD.

neXtProt entry for C8orf17 Gene

Post-translational modifications for C8orf17 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C8orf17 Gene

Domains & Families for C8orf17 Gene

Protein Domains for C8orf17 Gene


Suggested Antigen Peptide Sequences for C8orf17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf17: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf17 Gene

Function for C8orf17 Gene

Molecular function for C8orf17 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell survival, proliferation and progression of cancer cells.

Phenotypes for C8orf17 Gene

genes like me logo Genes that share phenotypes with C8orf17: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf17 Gene

Localization for C8orf17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C8orf17 Gene

Cytoplasm. Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf17 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for C8orf17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with C8orf17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C8orf17 Gene

Pathways & Interactions for C8orf17 Gene

SuperPathways for C8orf17 Gene

No Data Available

Interacting Proteins for C8orf17 Gene

Gene Ontology (GO) - Biological Process for C8orf17 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf17 Gene

Drugs & Compounds for C8orf17 Gene

No Compound Related Data Available

Transcripts for C8orf17 Gene

mRNA/cDNA for C8orf17 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf17 Gene

Chromosome 8 open reading frame 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf17 Gene

No ASD Table

Relevant External Links for C8orf17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf17 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf17 Gene:


SOURCE GeneReport for Unigene cluster for C8orf17 Gene:


mRNA Expression by UniProt/SwissProt for C8orf17 Gene:

Tissue specificity: Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested.
genes like me logo Genes that share expression patterns with C8orf17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf17 Gene

Orthologs for C8orf17 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C8orf17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C8orf17 34
  • 99 (a)
Species where no ortholog for C8orf17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf17 Gene

Gene Tree for C8orf17 (if available)
Gene Tree for C8orf17 (if available)

Paralogs for C8orf17 Gene

(12) SIMAP similar genes for C8orf17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C8orf17: view

No data available for Paralogs for C8orf17 Gene

Variants for C8orf17 Gene

Sequence variations from dbSNP and Humsavar for C8orf17 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs2233233 -- p.Thr19Met
rs2233235 -- p.Lys49Arg
rs2233236 -- p.Thr57Ile

Variation tolerance for C8orf17 Gene

Gene Damage Index Score: 1.06; 21.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C8orf17 Gene

Disorders for C8orf17 Gene

Additional Disease Information for C8orf17

No disorders were found for C8orf17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf17 Gene

Publications for C8orf17 Gene

  1. Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers. (PMID: 17143515) Tan JM … Chow VT (International journal of oncology 2007) 2 3 4 58
  2. The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate. (PMID: 12665628) Tan JM … Chow VT (Molecular pathology : MP 2003) 3 4 58
  3. High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. (PMID: 18000363) van Duin M … van Dekken H (Cytogenetic and genome research 2007) 3 58
  4. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for C8orf17 Gene

Sources for C8orf17 Gene

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