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The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
C8G (Complement C8 Gamma Chain) is a Protein Coding gene. Diseases associated with C8G include Immunodeficiency Due To A Late Component Of Complement Deficiency and Acute Salpingo-Oophoritis. Among its related pathways are Immune response Lectin induced complement pathway and Creation of C4 and C2 activators. Gene Ontology (GO) annotations related to this gene include complement binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001848 | complement binding | IEA,IBA | 21873635 |
GO:0019841 | retinol binding | IEA | -- |
GO:0044877 | protein-containing complex binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005579 | membrane attack complex | IEA | -- |
GO:0005615 | extracellular space | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
GO:0072562 | blood microparticle | HDA | 22516433 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response Lectin induced complement pathway |
Immune response Alternative complement pathway
.56
Immune response Lectin induced complement pathway
.56
Immune response Classical complement pathway
.55
|
|
2 | Complement Pathway |
Complement Pathway
.62
Alternative Complement Pathway
.01
|
Classical Complement Pathway
.01
Lectin Induced Complement Pathway
.01
|
3 | Complement and coagulation cascades | ||
4 | Creation of C4 and C2 activators | ||
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0006957 | complement activation, alternative pathway | IEA | -- |
GO:0006958 | complement activation, classical pathway | IEA | -- |
GO:0019835 | cytolysis | IEA | -- |
GO:0030449 | regulation of complement activation | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
lauric acid | Approved, Experimental | Pharma | Agonist, Target | 0 | ||
Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
Citric acid | Approved, Vet_approved | Nutra | Activator, Agonist, Target | 1509 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||
SP2: | |||||||||||||||
SP3: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | C8G 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | C8G 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | C8g 30 |
|
||
Mouse (Mus musculus) |
Mammalia | C8g 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | C8G 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | C8G 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | C8G 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | C8G 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | c8g 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | c8g 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
636372 | Uncertain Significance: not provided | 136,945,970(+) | CAG/C | FRAMESHIFT_VARIANT | |
769761 | Benign: not provided | 136,945,701(+) | G/A | MISSENSE_VARIANT | |
827972 | Uncertain Significance: not provided | 136,946,551(+) | T/C | MISSENSE_VARIANT | |
rs758635843 | Uncertain Significance: not provided | 136,945,408(+) | G/GCATCCCC | FRAMESHIFT_VARIANT | |
rs17613 | - | p.His124Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency due to a late component of complement deficiency |
|
|
acute salpingo-oophoritis |
|
|
salpingo-oophoritis |
|
|