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Aliases for C8G Gene

Aliases for C8G Gene

  • Complement C8 Gamma Chain 2 3 5
  • Complement Component 8, Gamma Polypeptide 2 3
  • Complement Component C8 Gamma Chain 3
  • C8C 3

External Ids for C8G Gene

Previous GeneCards Identifiers for C8G Gene

  • GC09U990012
  • GC09P131529
  • GC09P133280
  • GC09P135197
  • GC09P137115
  • GC09P138959
  • GC09P139839
  • GC09P109299

Summaries for C8G Gene

Entrez Gene Summary for C8G Gene

  • The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]

GeneCards Summary for C8G Gene

C8G (Complement C8 Gamma Chain) is a Protein Coding gene. Diseases associated with C8G include Immunodeficiency Due To A Late Component Of Complement Deficiency and Acute Salpingo-Oophoritis. Among its related pathways are Complement and coagulation cascades and Prion diseases. Gene Ontology (GO) annotations related to this gene include complement binding.

UniProtKB/Swiss-Prot for C8G Gene

  • C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Additional gene information for C8G Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8G Gene

Genomics for C8G Gene

GeneHancer (GH) Regulatory Elements for C8G Gene

Promoters and enhancers for C8G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J136942 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.6 2586 10.6 CLOCK ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 LCN12 C8G FBXW5 EHMT1 ANAPC2 ENTR1 DPH7 MAN1B1 SEC16A LOC100418938
GH09J136787 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.8 -150.2 -150162 14.2 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC TMEM141 CCDC183 DPH7 ANAPC2 LCN8 ABCA2 SNHG7 LCN10 EHMT1 EXD3
GH09J136884 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.8 -58.6 -58600 3.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B E2F8 LOC105376326 MIR4479 TRAF2 EHMT1 ENTR1 ANAPC2 PHPT1 SNHG7 LOC100418938 MAMDC4
GH09J136881 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.6 -62.2 -62213 2.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS TRAF2 PHPT1 MAMDC4 AJM1 TMEM141 LCN12 PRR31 C8G FBXW5 RABL6
GH09J136784 Enhancer 0.9 ENCODE 10.8 -159.3 -159308 1.8 PKNOX1 ATF1 ARNT DMAP1 TCF12 ZNF766 FOS ATF7 NCOA1 REST LCN8 ABCA2 NDOR1 LCN10 CCDC183-AS1 RABL6 LCN12 PRR31 FBXW5 C8G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8G gene promoter:
  • AP-2gamma
  • USF1
  • USF-1
  • HEN1
  • PPAR-gamma2
  • PPAR-gamma1
  • AML1a
  • p53
  • STAT3
  • ATF6

Genomic Locations for C8G Gene

Genomic Locations for C8G Gene
2,100 bases
Plus strand
1,729 bases
Plus strand

Genomic View for C8G Gene

Genes around C8G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8G Gene

Proteins for C8G Gene

  • Protein details for C8G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement component C8 gamma chain
    Protein Accession:
    Secondary Accessions:
    • Q14CT8
    • Q14CU0
    • Q5SQ07

    Protein attributes for C8G Gene

    202 amino acids
    Molecular mass:
    22277 Da
    Quaternary structure:
    • C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

    Three dimensional structures from OCA and Proteopedia for C8G Gene

neXtProt entry for C8G Gene

Post-translational modifications for C8G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8G Gene

Domains & Families for C8G Gene

Gene Families for C8G Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C8G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calycin superfamily. Lipocalin family.
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with C8G: view

Function for C8G Gene

Molecular function for C8G Gene

UniProtKB/Swiss-Prot Function:
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
GENATLAS Biochemistry:
complement component 8,gamma-1 globulin,complexing with other late components of the cascade to form the membrane attacks complex,gamma,(lipocalin family,Kernel group),associating with CD59,potential regulator of the complex helping to protect host cells from lysis

Phenotypes From GWAS Catalog for C8G Gene

Gene Ontology (GO) - Molecular Function for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019841 retinol binding IEA --
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with C8G: view
genes like me logo Genes that share phenotypes with C8G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C8G

miRNA for C8G Gene

miRTarBase miRNAs that target C8G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8G Gene

Localization for C8G Gene

Subcellular locations from UniProtKB/Swiss-Prot for C8G Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8G gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005579 membrane attack complex IEA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome HDA 23533145
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with C8G: view

Pathways & Interactions for C8G Gene

genes like me logo Genes that share pathways with C8G: view

Gene Ontology (GO) - Biological Process for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006957 complement activation, alternative pathway IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0019835 cytolysis IEA --
GO:0030449 regulation of complement activation TAS --
genes like me logo Genes that share ontologies with C8G: view

No data available for SIGNOR curated interactions for C8G Gene

Drugs & Compounds for C8G Gene

(3) Drugs for C8G Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lauric acid Approved, Experimental Pharma Agonist, Target 0
Zinc Approved, Investigational Pharma Target 2430
Citric Acid Approved, Vet_approved Nutra Agonist, Activator, Target 1243
genes like me logo Genes that share compounds with C8G: view

Transcripts for C8G Gene

mRNA/cDNA for C8G Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8G Gene

Complement component 8, gamma polypeptide:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP3: -

Relevant External Links for C8G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C8G Gene

This gene is overexpressed in Liver (x47.9).

Protein differential expression in normal tissues from HIPED for C8G Gene

This gene is overexpressed in Serum (18.6), Plasma (15.8), and Synovial fluid (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8G Gene

Protein tissue co-expression partners for C8G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C8G Gene:


SOURCE GeneReport for Unigene cluster for C8G Gene:


Evidence on tissue expression from TISSUES for C8G Gene

  • Liver(4.5)
  • Blood(4.2)
  • Intestine(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for C8G Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • meninges
  • mouth
  • neck
  • pharynx
  • esophagus
  • heart
  • lung
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
  • fallopian tube
  • ovary
  • prostate
  • rectum
  • testicle
  • urethra
  • vagina
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • blood
  • lymph node
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with C8G: view

No data available for mRNA Expression by UniProt/SwissProt for C8G Gene

Orthologs for C8G Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C8G 34 33
  • 92.93 (n)
(Canis familiaris)
Mammalia C8G 34 33
  • 83.17 (n)
(Rattus norvegicus)
Mammalia C8g 33
  • 81.62 (n)
(Mus musculus)
Mammalia C8g 16 34 33
  • 77.23 (n)
(Monodelphis domestica)
Mammalia C8G 34
  • 56 (a)
(Bos Taurus)
Mammalia C8G 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia C8G 34
  • 42 (a)
(Gallus gallus)
Aves C8G 34 33
  • 59.29 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia c8g 33
  • 59.09 (n)
(Danio rerio)
Actinopterygii c8g 34 33
  • 47.62 (n)
Species where no ortholog for C8G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8G Gene

Gene Tree for C8G (if available)
Gene Tree for C8G (if available)
Evolutionary constrained regions (ECRs) for C8G: view image

Paralogs for C8G Gene

(1) SIMAP similar genes for C8G Gene using alignment to 2 proteins:

  • Q5SQ08_HUMAN
genes like me logo Genes that share paralogs with C8G: view

No data available for Paralogs for C8G Gene

Variants for C8G Gene

Sequence variations from dbSNP and Humsavar for C8G Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000090562 -- 136,947,040(+) C/T downstream_transcript_variant
rs1000096153 -- 136,944,601(+) G/A upstream_transcript_variant
rs1000862310 -- 136,943,052(+) C/T upstream_transcript_variant
rs1001147315 -- 136,943,759(+) C/A upstream_transcript_variant
rs1001178432 -- 136,943,836(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C8G Gene

Variant ID Type Subtype PubMed ID
esv2422220 CNV deletion 17116639
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv615987 CNV loss 21841781
nsv818738 CNV gain 17921354
nsv951206 CNV deletion 24416366

Variation tolerance for C8G Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8G Gene

Disorders for C8G Gene

MalaCards: The human disease database

(3) MalaCards diseases for C8G Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
immunodeficiency due to a late component of complement deficiency
  • immunodeficiency due to c5 to c9 component complement deficiency
acute salpingo-oophoritis
  • acute salpingitis and oophoritis
  • salpingitis/oophoritis
- elite association - COSMIC cancer census association via MalaCards
Search C8G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for C8G

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with C8G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C8G Gene

Publications for C8G Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  3. Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family. (PMID: 17452033) Chiswell B … Sodetz JM (Biochimica et biophysica acta 2007) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site. (PMID: 12033936) Ortlund E … Lebioda L (Biochemistry 2002) 3 4 58

Products for C8G Gene

Sources for C8G Gene

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