Aliases for C8A Gene
External Ids for C8A Gene
Previous GeneCards Identifiers for C8A Gene
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
GeneCards Summary for C8A Gene
C8A (Complement C8 Alpha Chain) is a Protein Coding gene. Diseases associated with C8A include Complement Component 8 Deficiency, Type I and Immunodeficiency Due To A Late Component Of Complement Deficiency. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include protein complex binding and complement binding. An important paralog of this gene is C8B.
UniProtKB/Swiss-Prot for C8A Gene
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.