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Aliases for C7orf65 Gene

Aliases for C7orf65 Gene

  • Chromosome 7 Open Reading Frame 65 2 3 5

External Ids for C7orf65 Gene

Previous GeneCards Identifiers for C7orf65 Gene

  • GC07P047663

Summaries for C7orf65 Gene

GeneCards Summary for C7orf65 Gene

C7orf65 (Chromosome 7 Open Reading Frame 65) is a Protein Coding gene.

Additional gene information for C7orf65 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf65 Gene

Genomics for C7orf65 Gene

GeneHancer (GH) Regulatory Elements for C7orf65 Gene

Promoters and enhancers for C7orf65 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I047570 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -77.7 -77650 15 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 TNS3 C7orf65 C7orf69 GC07P047460
GH07I047478 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -170.8 -170833 11.2 PKNOX1 FOXA2 ATF1 YY1 TCF12 FOS ATF7 RUNX3 RXRA NCOA1 TNS3 C7orf65 C7orf69 PKD1L1 HUS1 GC07P047460
GH07I047493 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -156.0 -155954 11.2 PKNOX1 FOXA2 MLX ARID4B FEZF1 ZNF48 ETS1 YY1 SLC30A9 FOS TNS3 C7orf65 C7orf69 ABCA13 HUS1 GC07P047460
GH07I047782 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +130.3 130304 6.7 FOXA2 SIN3A DMAP1 ZNF48 ETS1 GLIS2 ATF7 FOS DEK SP5 LINC00525 C7orf65 TNS3 C7orf69 PKD1L1 HUS1
GH07I047533 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -116.0 -115985 11.7 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 RXRA SP5 NFYC TNS3 C7orf69 C7orf65 GC07P047460
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C7orf65 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C7orf65 gene promoter:

Genomic Locations for C7orf65 Gene

Genomic Locations for C7orf65 Gene
chr7:47,655,244-47,661,648
(GRCh38/hg38)
Size:
6,405 bases
Orientation:
Plus strand
chr7:47,694,842-47,701,246
(GRCh37/hg19)

Genomic View for C7orf65 Gene

Genes around C7orf65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf65 Gene

Proteins for C7orf65 Gene

  • Protein details for C7orf65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTY9-CG065_HUMAN
    Recommended name:
    Uncharacterized protein C7orf65
    Protein Accession:
    Q6ZTY9
    Secondary Accessions:
    • A4D2F8

    Protein attributes for C7orf65 Gene

    Size:
    151 amino acids
    Molecular mass:
    16773 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAL23804.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C7orf65 Gene

Post-translational modifications for C7orf65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf65 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C7orf65 Gene

Domains & Families for C7orf65 Gene

Protein Domains for C7orf65 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf65: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf65 Gene

Function for C7orf65 Gene

Phenotypes From GWAS Catalog for C7orf65 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf65 Gene

Localization for C7orf65 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C7orf65 gene
Compartment Confidence
extracellular 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C7orf65 Gene

Pathways & Interactions for C7orf65 Gene

SuperPathways for C7orf65 Gene

No Data Available

Interacting Proteins for C7orf65 Gene

Gene Ontology (GO) - Biological Process for C7orf65 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C7orf65 Gene

Drugs & Compounds for C7orf65 Gene

No Compound Related Data Available

Transcripts for C7orf65 Gene

mRNA/cDNA for C7orf65 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C7orf65 Gene

Chromosome 7 open reading frame 65:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf65 Gene

No ASD Table

Relevant External Links for C7orf65 Gene

GeneLoc Exon Structure for
C7orf65
ECgene alternative splicing isoforms for
C7orf65

Expression for C7orf65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf65 Gene

mRNA differential expression in normal tissues according to GTEx for C7orf65 Gene

This gene is overexpressed in Testis (x5.5) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of C7orf65 Gene:

C7orf65

SOURCE GeneReport for Unigene cluster for C7orf65 Gene:

Hs.520816
genes like me logo Genes that share expression patterns with C7orf65: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf65 Gene

Orthologs for C7orf65 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C7orf65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf65 33
  • 98.9 (n)
C7orf65 34
  • 97 (a)
OneToOne
Species where no ortholog for C7orf65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C7orf65 Gene

ENSEMBL:
Gene Tree for C7orf65 (if available)
TreeFam:
Gene Tree for C7orf65 (if available)

Paralogs for C7orf65 Gene

No data available for Paralogs for C7orf65 Gene

Variants for C7orf65 Gene

Sequence variations from dbSNP and Humsavar for C7orf65 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000415366 -- 47,661,516(+) G/T 3_prime_UTR_variant
rs1001251210 -- 47,659,043(+) T/C/G coding_sequence_variant, missense_variant
rs1001905395 -- 47,658,908(+) G/A coding_sequence_variant, missense_variant
rs1002133960 -- 47,654,068(+) G/A upstream_transcript_variant
rs1002771961 -- 47,654,140(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf65 Gene

Variant ID Type Subtype PubMed ID
esv3613064 CNV gain 21293372
esv3613065 CNV gain 21293372
nsv5730 CNV insertion 18451855

Variation tolerance for C7orf65 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C7orf65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf65 Gene

Disorders for C7orf65 Gene

Additional Disease Information for C7orf65

No disorders were found for C7orf65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf65 Gene

Publications for C7orf65 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for C7orf65 Gene

Sources for C7orf65 Gene

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