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Aliases for C7orf55-LUC7L2 Gene

Aliases for C7orf55-LUC7L2 Gene

  • C7orf55-LUC7L2 Readthrough 2 3 5
  • C7orf55-LUC7L2 Protein 3

External Ids for C7orf55-LUC7L2 Gene

Previous GeneCards Identifiers for C7orf55-LUC7L2 Gene

  • GC07P139031
  • GC07P139036
  • GC07P139041
  • GC07P139342
  • GC07P139343
  • GC07P139345
  • GC07P139346
  • GC07P139348
  • GC07P139350
  • GC07P139352
  • GC07P139354

Summaries for C7orf55-LUC7L2 Gene

Entrez Gene Summary for C7orf55-LUC7L2 Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2012]

GeneCards Summary for C7orf55-LUC7L2 Gene

C7orf55-LUC7L2 (C7orf55-LUC7L2 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is LUC7L2.

Additional gene information for C7orf55-LUC7L2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf55-LUC7L2 Gene

Genomics for C7orf55-LUC7L2 Gene

GeneHancer (GH) Regulatory Elements for C7orf55-LUC7L2 Gene

Promoters and enhancers for C7orf55-LUC7L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J139339 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.2 152 3.9 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D LUC7L2 C7orf55-LUC7L2 GC07P139358 GC07P139359 FMC1 TRR-CCT4-1 UBN2 ENSG00000273391 KLRG2 TTC26
GH07J139357 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.4 +19.0 19003 4.3 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 LUC7L2 ENSG00000273391 UBN2 IMPDH1P3 RNU6-206P TBXAS1 GC07P139363 C7orf55-LUC7L2
GH07J139367 Promoter/Enhancer 1.1 EPDnew dbSUPER 0.3 +26.6 26600 0.1 ZNF189 MAFG EBF1 MEF2B BATF ATF2 ZNF316 NFE2 EMSY ZBTB17 LUC7L2 FMC1 GC07P139363 C7orf55-LUC7L2 LOC100129148
GH07J139363 Promoter/Enhancer 1 EPDnew dbSUPER 0.3 +21.5 21491 0.1 GLIS2 ZBTB48 IKZF1 ZNF580 MZF1 PRDM10 GC07P139363 LUC7L2 ENSG00000273391 C7orf55-LUC7L2
GH07J139364 Enhancer 0.8 ENCODE dbSUPER 0.3 +21.3 21318 0.2 MZF1 ZNF395 GLIS2 ZBTB48 IKZF1 ZNF580 PRDM10 PRDM4 GC07P139363 ENSG00000273391 LUC7L2 C7orf55-LUC7L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C7orf55-LUC7L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C7orf55-LUC7L2 Gene

Genomic Locations for C7orf55-LUC7L2 Gene
chr7:139,341,132-139,423,457
(GRCh38/hg38)
Size:
82,326 bases
Orientation:
Plus strand
chr7:139,025,105-139,108,198
(GRCh37/hg19)
Size:
83,094 bases
Orientation:
Plus strand

Genomic View for C7orf55-LUC7L2 Gene

Genes around C7orf55-LUC7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf55-LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf55-LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf55-LUC7L2 Gene

Proteins for C7orf55-LUC7L2 Gene

  • Protein details for C7orf55-LUC7L2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYJ8-A0A0A6YYJ8_HUMAN
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    A0A0A6YYJ8

    Protein attributes for C7orf55-LUC7L2 Gene

    Size:
    458 amino acids
    Molecular mass:
    54224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C7orf55-LUC7L2 Gene

Protein Expression for C7orf55-LUC7L2 Gene

Post-translational modifications for C7orf55-LUC7L2 Gene

No Post-translational modifications

Other Protein References for C7orf55-LUC7L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C7orf55-LUC7L2 Gene

Domains & Families for C7orf55-LUC7L2 Gene

Gene Families for C7orf55-LUC7L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C7orf55-LUC7L2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf55-LUC7L2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf55-LUC7L2 Gene

Function for C7orf55-LUC7L2 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C7orf55-LUC7L2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf55-LUC7L2 Gene

Localization for C7orf55-LUC7L2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C7orf55-LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005685 U1 snRNP IEA --
genes like me logo Genes that share ontologies with C7orf55-LUC7L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C7orf55-LUC7L2 Gene

Pathways & Interactions for C7orf55-LUC7L2 Gene

SuperPathways for C7orf55-LUC7L2 Gene

No Data Available

Interacting Proteins for C7orf55-LUC7L2 Gene

Gene Ontology (GO) - Biological Process for C7orf55-LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IEA --
genes like me logo Genes that share ontologies with C7orf55-LUC7L2: view

No data available for Pathways by source and SIGNOR curated interactions for C7orf55-LUC7L2 Gene

Drugs & Compounds for C7orf55-LUC7L2 Gene

No Compound Related Data Available

Transcripts for C7orf55-LUC7L2 Gene

mRNA/cDNA for C7orf55-LUC7L2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C7orf55-LUC7L2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf55-LUC7L2 Gene

No ASD Table

Relevant External Links for C7orf55-LUC7L2 Gene

GeneLoc Exon Structure for
C7orf55-LUC7L2
ECgene alternative splicing isoforms for
C7orf55-LUC7L2

Expression for C7orf55-LUC7L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf55-LUC7L2 Gene

Protein differential expression in normal tissues from HIPED for C7orf55-LUC7L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1) and Heart (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for C7orf55-LUC7L2 Gene



Protein tissue co-expression partners for C7orf55-LUC7L2 Gene

- Elite partner
genes like me logo Genes that share expression patterns with C7orf55-LUC7L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf55-LUC7L2 Gene

Orthologs for C7orf55-LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C7orf55-LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LUC7L2 34
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Luc7l2 34
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves LUC7L2 34
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 86 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii C1H7orf55 34
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7564 34
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.8 34
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToMany
Species where no ortholog for C7orf55-LUC7L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for C7orf55-LUC7L2 Gene

ENSEMBL:
Gene Tree for C7orf55-LUC7L2 (if available)
TreeFam:
Gene Tree for C7orf55-LUC7L2 (if available)

Paralogs for C7orf55-LUC7L2 Gene

Paralogs for C7orf55-LUC7L2 Gene

(2) SIMAP similar genes for C7orf55-LUC7L2 Gene using alignment to 2 proteins:

  • F8WEU3_HUMAN
  • V9GZ75_HUMAN
genes like me logo Genes that share paralogs with C7orf55-LUC7L2: view

Variants for C7orf55-LUC7L2 Gene

Sequence variations from dbSNP and Humsavar for C7orf55-LUC7L2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000078372 -- 139,356,027(+) C/T intron_variant
rs1000154260 -- 139,366,595(+) C/T intron_variant
rs1000162485 -- 139,359,653(+) C/A intron_variant
rs1000163825 -- 139,379,124(+) G/A intron_variant
rs1000174566 -- 139,339,878(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf55-LUC7L2 Gene

Variant ID Type Subtype PubMed ID
esv2292861 CNV deletion 18987734
esv2371727 CNV deletion 18987734
esv2735212 CNV deletion 23290073
esv2735231 CNV deletion 23290073
esv3572165 CNV loss 25503493
esv3572166 CNV loss 25503493
nsv1110976 OTHER inversion 24896259
nsv1117762 CNV deletion 24896259
nsv1137296 CNV deletion 24896259
nsv478581 CNV novel sequence insertion 20440878

Variation tolerance for C7orf55-LUC7L2 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C7orf55-LUC7L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf55-LUC7L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf55-LUC7L2 Gene

Disorders for C7orf55-LUC7L2 Gene

Additional Disease Information for C7orf55-LUC7L2

No disorders were found for C7orf55-LUC7L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf55-LUC7L2 Gene

Publications for C7orf55-LUC7L2 Gene

  1. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  2. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 58
  5. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 58

Products for C7orf55-LUC7L2 Gene

Sources for C7orf55-LUC7L2 Gene

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