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Aliases for C7orf31 Gene

Aliases for C7orf31 Gene

  • Chromosome 7 Open Reading Frame 31 2 3 5

External Ids for C7orf31 Gene

Previous GeneCards Identifiers for C7orf31 Gene

  • GC07M024882
  • GC07M024916
  • GC07M024947
  • GC07M025140

Summaries for C7orf31 Gene

GeneCards Summary for C7orf31 Gene

C7orf31 (Chromosome 7 Open Reading Frame 31) is a Protein Coding gene.

Additional gene information for C7orf31 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf31 Gene

Genomics for C7orf31 Gene

GeneHancer (GH) Regulatory Elements for C7orf31 Gene

Promoters and enhancers for C7orf31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I025179 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.5 483 1.5 HDGF RB1 ARID4B SIN3A ZBTB40 IRF4 ZNF48 RAD21 YY1 ZNF335 C7orf31 GC07M025179 OSBPL3 PIR55615
GH07I025845 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -671.8 -671780 14.1 HDGF PKNOX1 CLOCK FOXA2 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF766 HNRNPA2B1 C7orf31 LOC646588 TSEN15P3 ENSG00000202233 C7orf71 LOC100506236 GC07M025774
GH07I025568 Enhancer 0.9 ENCODE 11.4 -388.0 -387957 0.8 CLOCK FOXA2 MLX ARID4B DMAP1 E2F8 ZNF143 FOS RUNX3 NCOA1 C7orf31 TSEN15P3 ENSG00000202233 ENSG00000227386 GC07P025596
GH07I024794 Enhancer 0.8 Ensembl 11.4 +386.2 386247 0.2 HDAC1 HDGF ARNT NFRKB NFXL1 ZBTB40 ZNF48 TCF12 E2F8 ARID2 C7orf31 GSDME MPP6 SNRPCP19
GH07I024819 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +359.1 359065 3.7 PKNOX1 ARNT ARID4B SIN3A IRF4 ZNF766 ZNF207 ZNF143 FOS NFYC OSBPL3 GSDME C7orf31 SNRPCP19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C7orf31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C7orf31 gene promoter:

Genomic Locations for C7orf31 Gene

Genomic Locations for C7orf31 Gene
chr7:25,125,200-25,180,748
(GRCh38/hg38)
Size:
55,549 bases
Orientation:
Minus strand
chr7:25,174,316-25,219,975
(GRCh37/hg19)

Genomic View for C7orf31 Gene

Genes around C7orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf31 Gene

Proteins for C7orf31 Gene

  • Protein details for C7orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N865-CG031_HUMAN
    Recommended name:
    Uncharacterized protein C7orf31
    Protein Accession:
    Q8N865
    Secondary Accessions:
    • A4D165
    • Q6MZV8
    • Q6P989
    • Q7LE28
    • Q86XK1
    • Q8N1H5
    • Q96BN4

    Protein attributes for C7orf31 Gene

    Size:
    590 amino acids
    Molecular mass:
    68464 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP22338.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC05255.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C7orf31 Gene

Post-translational modifications for C7orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf31 Gene

No data available for DME Specific Peptides for C7orf31 Gene

Domains & Families for C7orf31 Gene

Gene Families for C7orf31 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C7orf31 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf31: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf31 Gene

Function for C7orf31 Gene

Phenotypes From GWAS Catalog for C7orf31 Gene

Gene Ontology (GO) - Molecular Function for C7orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C7orf31: view
genes like me logo Genes that share phenotypes with C7orf31: view

miRNA for C7orf31 Gene

miRTarBase miRNAs that target C7orf31

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf31 Gene

Localization for C7orf31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C7orf31 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C7orf31 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C7orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with C7orf31: view

Pathways & Interactions for C7orf31 Gene

SuperPathways for C7orf31 Gene

No Data Available

Interacting Proteins for C7orf31 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283905%0d%0a9606.ENSP00000287777%0d%0a
Selected Interacting proteins: ENSP00000283905 Q8N865-CG031_HUMAN for C7orf31 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for C7orf31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C7orf31 Gene

Drugs & Compounds for C7orf31 Gene

No Compound Related Data Available

Transcripts for C7orf31 Gene

Unigene Clusters for C7orf31 Gene

Chromosome 7 open reading frame 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for C7orf31 Gene

GeneLoc Exon Structure for
C7orf31
ECgene alternative splicing isoforms for
C7orf31

Expression for C7orf31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf31 Gene

mRNA differential expression in normal tissues according to GTEx for C7orf31 Gene

This gene is overexpressed in Testis (x13.2).

Protein differential expression in normal tissues from HIPED for C7orf31 Gene

This gene is overexpressed in Testis (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C7orf31 Gene



Protein tissue co-expression partners for C7orf31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C7orf31 Gene:

C7orf31

SOURCE GeneReport for Unigene cluster for C7orf31 Gene:

Hs.122055

Evidence on tissue expression from TISSUES for C7orf31 Gene

  • Intestine(4.1)
  • Kidney(4.1)
  • Spleen(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with C7orf31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf31 Gene

Orthologs for C7orf31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C7orf31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf31 33
  • 99.04 (n)
C7orf31 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14H7orf31 33
  • 88.11 (n)
C7orf31 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4H7orf31 33
  • 86.82 (n)
C7orf31 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4921507P07Rik 33 16 34
  • 79.76 (n)
rat
(Rattus norvegicus)
Mammalia LOC500124 33
  • 78.97 (n)
oppossum
(Monodelphis domestica)
Mammalia C7orf31 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf31 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H7ORF31 33
  • 54.42 (n)
C7orf31 34
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C7orf31 34
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497526 33
  • 51.15 (n)
Species where no ortholog for C7orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C7orf31 Gene

ENSEMBL:
Gene Tree for C7orf31 (if available)
TreeFam:
Gene Tree for C7orf31 (if available)

Paralogs for C7orf31 Gene

No data available for Paralogs for C7orf31 Gene

Variants for C7orf31 Gene

Sequence variations from dbSNP and Humsavar for C7orf31 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000072293 -- 25,153,837(-) T/A intron_variant
rs1000079702 -- 25,142,410(-) T/C intron_variant
rs1000253027 -- 25,177,793(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000263458 -- 25,137,449(-) A/G intron_variant
rs1000350479 -- 25,182,008(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf31 Gene

Variant ID Type Subtype PubMed ID
esv3612592 CNV loss 21293372
nsv510075 OTHER sequence alteration 20534489
nsv606424 CNV gain 21841781
nsv7393 OTHER inversion 18451855

Variation tolerance for C7orf31 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.81; 97.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C7orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf31 Gene

Disorders for C7orf31 Gene

Additional Disease Information for C7orf31

No disorders were found for C7orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf31 Gene

Publications for C7orf31 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C7orf31 Gene

Sources for C7orf31 Gene

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