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Aliases for C7orf25 Gene

Aliases for C7orf25 Gene

  • Chromosome 7 Open Reading Frame 25 2 3 5
  • UPF0415 Protein C7orf25 3

External Ids for C7orf25 Gene

Previous GeneCards Identifiers for C7orf25 Gene

  • GC07M042655
  • GC07M042689
  • GC07M042722
  • GC07M042915
  • GC07M042833
  • GC07M042948

Summaries for C7orf25 Gene

GeneCards Summary for C7orf25 Gene

C7orf25 (Chromosome 7 Open Reading Frame 25) is a Protein Coding gene.

Additional gene information for C7orf25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf25 Gene

Genomics for C7orf25 Gene

GeneHancer (GH) Regulatory Elements for C7orf25 Gene

Promoters and enhancers for C7orf25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J042911 Promoter/Enhancer 1.6 Ensembl ENCODE 696.8 +0.1 112 2.3 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B C7orf25 MRPL32 ENSG00000261019 ENSG00000256646
GH07J042930 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 43 -19.8 -19830 3.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ZNF207 MRPL32 PSMA2 ENSG00000256646 C7orf25 LOC105375252
GH07J042887 Enhancer 1.6 FANTOM5 Ensembl ENCODE 40.4 +23.8 23804 3 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 ZNF143 SP3 C7orf25 GC07M042892 ENSG00000231539
GH07J042913 Enhancer 0.9 FANTOM5 Ensembl ENCODE 44.3 -2.1 -2120 1.4 ZNF121 JUN RUNX3 ZBTB17 C7orf25 MRPL32 LOC105375252 ENSG00000256646
GH07J042940 Enhancer 0.9 Ensembl ENCODE 27.8 -29.1 -29077 0.9 CTCF MXI1 MAX SIN3A ZNF2 RAD21 CC2D1A GATA3 ARID2 SCRT2 C7orf25 MRPL32 PSMA2 GC07P043096
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C7orf25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C7orf25 gene promoter:

Genomic Locations for C7orf25 Gene

Genomic Locations for C7orf25 Gene
3,580 bases
Minus strand

Genomic View for C7orf25 Gene

Genes around C7orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf25 Gene

Proteins for C7orf25 Gene

  • Protein details for C7orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0415 protein C7orf25
    Protein Accession:
    Secondary Accessions:
    • A4D1V2
    • J3KR36
    • Q9H779

    Protein attributes for C7orf25 Gene

    421 amino acids
    Molecular mass:
    46451 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C7orf25 Gene


neXtProt entry for C7orf25 Gene

Post-translational modifications for C7orf25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C7orf25 Gene

Domains & Families for C7orf25 Gene

Gene Families for C7orf25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C7orf25 Gene


Suggested Antigen Peptide Sequences for C7orf25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0415 family.
  • Belongs to the UPF0415 family.
genes like me logo Genes that share domains with C7orf25: view

Function for C7orf25 Gene

Gene Ontology (GO) - Molecular Function for C7orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C7orf25: view
genes like me logo Genes that share phenotypes with C7orf25: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C7orf25 Gene

Localization for C7orf25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C7orf25 gene
Compartment Confidence
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C7orf25 Gene

Pathways & Interactions for C7orf25 Gene

SuperPathways for C7orf25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C7orf25 Gene


No data available for Pathways by source and SIGNOR curated interactions for C7orf25 Gene

Drugs & Compounds for C7orf25 Gene

No Compound Related Data Available

Transcripts for C7orf25 Gene

Unigene Clusters for C7orf25 Gene

Chromosome 7 open reading frame 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf25 Gene

No ASD Table

Relevant External Links for C7orf25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C7orf25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf25 Gene

Protein differential expression in normal tissues from HIPED for C7orf25 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.4), Spleen (7.5), and Skin (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C7orf25 Gene

NURSA nuclear receptor signaling pathways regulating expression of C7orf25 Gene:


SOURCE GeneReport for Unigene cluster for C7orf25 Gene:


Evidence on tissue expression from TISSUES for C7orf25 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with C7orf25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf25 Gene

Orthologs for C7orf25 Gene

This gene was present in the common ancestor of animals.

Orthologs for C7orf25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C7orf25 34
  • 100 (a)
C7H7orf25 33
  • 99.72 (n)
(Bos Taurus)
Mammalia C7orf25 34
  • 98 (a)
C4H7orf25 33
  • 91.84 (n)
(Canis familiaris)
Mammalia C7orf25 34
  • 97 (a)
C18H7orf25 33
  • 93.03 (n)
(Rattus norvegicus)
Mammalia RGD1308147 33
  • 88.36 (n)
(Mus musculus)
Mammalia AW209491 16 34 33
  • 88.12 (n)
(Ornithorhynchus anatinus)
Mammalia C7orf25 34
  • 86 (a)
(Monodelphis domestica)
Mammalia C7orf25 34
  • 72 (a)
(Gallus gallus)
Aves C7orf25 34
  • 81 (a)
C2H7ORF25 33
  • 74.07 (n)
(Anolis carolinensis)
Reptilia C7orf25 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c7orf25 33
  • 73.73 (n)
Str.14994 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10096 33
(Danio rerio)
Actinopterygii C2H7orf25 34
  • 71 (a)
zgc:55781 33
  • 66.42 (n)
Dr.207 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5893 33
fruit fly
(Drosophila melanogaster)
Insecta CG42553 34 33
  • 47.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004537 33
  • 45.67 (n)
(Caenorhabditis elegans)
Secernentea F33G12.3 34 33
  • 43.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for C7orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C7orf25 Gene

Gene Tree for C7orf25 (if available)
Gene Tree for C7orf25 (if available)

Paralogs for C7orf25 Gene

No data available for Paralogs for C7orf25 Gene

Variants for C7orf25 Gene

Sequence variations from dbSNP and Humsavar for C7orf25 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000335453 -- 42,913,264(-) C/T upstream_transcript_variant
rs1000430279 -- 42,912,952(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000736839 -- 42,909,254(-) A/C downstream_transcript_variant
rs1001996145 -- 42,914,760(-) C/T upstream_transcript_variant
rs1002588763 -- 42,912,496(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf25 Gene

Variant ID Type Subtype PubMed ID
nsv606715 CNV gain 21841781
nsv830979 CNV gain 17160897

Variation tolerance for C7orf25 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C7orf25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf25 Gene

Disorders for C7orf25 Gene

Additional Disease Information for C7orf25

No disorders were found for C7orf25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf25 Gene

Publications for C7orf25 Gene

  1. Comprehensive classification of the PIN domain-like superfamily. (PMID: 28575517) Matelska D … Ginalski K (Nucleic acids research 2017) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho CE … Valentini SR (Experimental cell research 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for C7orf25 Gene

Sources for C7orf25 Gene

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