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Aliases for C6orf58 Gene

Aliases for C6orf58 Gene

  • Chromosome 6 Open Reading Frame 58 2 3 5
  • Liver Enriched Gene 1 Homolog 2 3
  • UPF0762 Protein C6orf58 3
  • Protein LEG1 Homolog 3
  • LEG1 3

External Ids for C6orf58 Gene

Previous GeneCards Identifiers for C6orf58 Gene

  • GC06U900113
  • GC06P127941
  • GC06P127840
  • GC06P125474

Summaries for C6orf58 Gene

GeneCards Summary for C6orf58 Gene

C6orf58 (Chromosome 6 Open Reading Frame 58) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C6orf58 Gene

  • May be involved in early liver development.

Additional gene information for C6orf58 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf58 Gene

Genomics for C6orf58 Gene

GeneHancer (GH) Regulatory Elements for C6orf58 Gene

Promoters and enhancers for C6orf58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J127340 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 656.5 -176.7 -176727 4.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 ECHDC1 C6orf58 GC06P127344 KIAA0408 RNA5SP217 LOC105377994
GH06J127518 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 -0.4 -387 1.5 KLF17 SIN3A ZNF2 ZNF335 ZSCAN5C RCOR1 EGR2 SP3 USF2 ELF1 SOGA3 ENSG00000255330 C6orf58 KIAA0408
GH06J127577 Promoter 0.5 EPDnew 661.2 +57.7 57700 0.1 C6orf58 LOC105377995
GH06J127481 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.4 -36.1 -36141 4 FOXA2 SIN3A BATF ETS1 ZEB1 ZNF366 ATF7 FOS JUNB CEBPB C6orf58 KIAA0408 ENSG00000255330 SOGA3 ECHDC1 PIR32248
GH06J127383 Enhancer 0.3 ENCODE 6.5 -134.2 -134207 3.6 DACH1 ECHDC1 C6orf58 GC06P127375 LOC100287856
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C6orf58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C6orf58 gene promoter:
  • MEF-2A
  • aMEF-2
  • SRY
  • TBP
  • RelA
  • AREB6
  • NF-kappaB1
  • Pax-4a

Genomic Locations for C6orf58 Gene

Genomic Locations for C6orf58 Gene
72,364 bases
Plus strand
72,363 bases
Plus strand

Genomic View for C6orf58 Gene

Genes around C6orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf58 Gene

Proteins for C6orf58 Gene

  • Protein details for C6orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein LEG1 homolog
    Protein Accession:
    Secondary Accessions:
    • B4E1I0
    • Q5VUP2

    Protein attributes for C6orf58 Gene

    330 amino acids
    Molecular mass:
    37926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf58 Gene

Post-translational modifications for C6orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf58 Gene

Domains & Families for C6orf58 Gene

Gene Families for C6orf58 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C6orf58 Gene


Suggested Antigen Peptide Sequences for C6orf58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LEG1 family.
  • Belongs to the LEG1 family.
genes like me logo Genes that share domains with C6orf58: view

Function for C6orf58 Gene

Molecular function for C6orf58 Gene

UniProtKB/Swiss-Prot Function:
May be involved in early liver development.

Phenotypes From GWAS Catalog for C6orf58 Gene

genes like me logo Genes that share phenotypes with C6orf58: view

miRNA for C6orf58 Gene

miRTarBase miRNAs that target C6orf58

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf58 Gene

Localization for C6orf58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf58 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf58 gene
Compartment Confidence
extracellular 5
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for C6orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with C6orf58: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C6orf58 Gene

Pathways & Interactions for C6orf58 Gene

SuperPathways for C6orf58 Gene

No Data Available

Interacting Proteins for C6orf58 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000328069 for C6orf58 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C6orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with C6orf58: view

No data available for Pathways by source and SIGNOR curated interactions for C6orf58 Gene

Drugs & Compounds for C6orf58 Gene

No Compound Related Data Available

Transcripts for C6orf58 Gene

mRNA/cDNA for C6orf58 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf58 Gene

Chromosome 6 open reading frame 58:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf58 Gene

No ASD Table

Relevant External Links for C6orf58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C6orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf58 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf58 Gene

This gene is overexpressed in Minor Salivary Gland (x51.9).

Protein differential expression in normal tissues from HIPED for C6orf58 Gene

This gene is overexpressed in Pancreatic juice (36.5), Saliva (16.9), and Skin (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf58 Gene

Protein tissue co-expression partners for C6orf58 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf58 Gene:


SOURCE GeneReport for Unigene cluster for C6orf58 Gene:


mRNA Expression by UniProt/SwissProt for C6orf58 Gene:

Tissue specificity: Detected in saliva and in hypomineralized dental enamel (at protein level).

Evidence on tissue expression from TISSUES for C6orf58 Gene

  • Saliva(4)
  • Intestine(2.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with C6orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf58 Gene

Orthologs for C6orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6orf58 34
  • 100 (a)
C6H6orf58 33
  • 99.49 (n)
(Canis familiaris)
Mammalia C1H6orf58 33
  • 79.39 (n)
C6orf58 34
  • 68 (a)
(Bos Taurus)
Mammalia C6orf58 34
  • 64 (a)
(Mus musculus)
Mammalia 2310057J18Rik 34
  • 53 (a)
(Monodelphis domestica)
Mammalia C6orf58 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia C6orf58 34
  • 45 (a)
(Gallus gallus)
Aves C6orf58 34
  • 34 (a)
(Anolis carolinensis)
Reptilia C6orf58 34
  • 38 (a)
(Danio rerio)
Actinopterygii C20H6orf58 (1 of 2) 34
  • 30 (a)
C20H6orf58 (2 of 2) 34
  • 29 (a)
Species where no ortholog for C6orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C6orf58 Gene

Gene Tree for C6orf58 (if available)
Gene Tree for C6orf58 (if available)

Paralogs for C6orf58 Gene Pseudogenes for C6orf58 Gene

genes like me logo Genes that share paralogs with C6orf58: view

No data available for Paralogs for C6orf58 Gene

Variants for C6orf58 Gene

Sequence variations from dbSNP and Humsavar for C6orf58 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000084952 -- 127,581,225(+) A/G coding_sequence_variant, missense_variant
rs1000464340 -- 127,576,506(+) C/T upstream_transcript_variant
rs1000491701 -- 127,584,630(+) C/T intron_variant
rs1000503280 -- 127,578,310(+) T/G intron_variant
rs1000553179 -- 127,576,061(+) GGATGTTTAATGTGGA/GGA upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf58 Gene

Variant ID Type Subtype PubMed ID
nsv1024149 CNV loss 25217958
nsv5469 CNV insertion 18451855
nsv830798 CNV loss 17160897

Variation tolerance for C6orf58 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf58 Gene

Disorders for C6orf58 Gene

Additional Disease Information for C6orf58

No disorders were found for C6orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf58 Gene

Publications for C6orf58 Gene

  1. Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. (PMID: 26901320) Hu M … Peng J (PLoS genetics 2016) 2 3 58
  2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C6orf58 Gene

Sources for C6orf58 Gene

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