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Aliases for C6orf226 Gene

Aliases for C6orf226 Gene

  • Chromosome 6 Open Reading Frame 226 2 3 5
  • Uncharacterized Protein C6orf226 3

External Ids for C6orf226 Gene

Previous GeneCards Identifiers for C6orf226 Gene

  • GC06M042965
  • GC06M042858
  • GC06M042575

Summaries for C6orf226 Gene

GeneCards Summary for C6orf226 Gene

C6orf226 (Chromosome 6 Open Reading Frame 226) is a Protein Coding gene.

Additional gene information for C6orf226 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf226 Gene

Genomics for C6orf226 Gene

GeneHancer (GH) Regulatory Elements for C6orf226 Gene

Promoters and enhancers for C6orf226 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J042889 Promoter/Enhancer 1.6 Ensembl ENCODE 658.7 +0.2 167 2.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 C6orf226 PIR42130 GC06P042892 ZNF318 POLH RPS2P29 POLR1C XPO5 GTPBP2 UBR2
GH06J042878 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.3 +10.7 10736 2.5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 ZNF610 RPL7L1 GC06P042879 PIR42746 GC06P042880 ZNF318 POLH ABCC10 CUL7 POLR1C PEX6
GH06J042769 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +119.4 119402 3 HDGF PKNOX1 SIN3A KLF5 ZNF207 ZNF143 ATF7 IKZF2 RUNX3 CREM TBCC CUL7 RPL7L1 CUL9 ABCC10 TRERF1 C6orf226 PRPH2 BICRAL GNMT
GH06J042877 Enhancer 1.1 Ensembl ENCODE 8.3 +13.2 13204 1.2 ARID4B DMAP1 ZNF2 YY1 ZNF143 NFKBIZ NCOA1 REST MIER3 ETV4 PEX6 C6orf226 RPL7L1 LOC401261
GH06J042916 Promoter/Enhancer 0.8 EPDnew dbSUPER 10.9 -25.2 -25218 0.1 RUNX3 PTCRA ENSG00000231113 PPP2R5D RPL7L1 C6orf226 PEX6 KLHDC3 MEA1 CUL9 RNU6-890P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C6orf226 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C6orf226 gene promoter:
  • STAT5A
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for C6orf226 Gene

Genomic Locations for C6orf226 Gene
552 bases
Minus strand
552 bases
Minus strand

Genomic View for C6orf226 Gene

Genes around C6orf226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf226 Gene

Proteins for C6orf226 Gene

  • Protein details for C6orf226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C6orf226
    Protein Accession:

    Protein attributes for C6orf226 Gene

    101 amino acids
    Molecular mass:
    10566 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf226 Gene

Post-translational modifications for C6orf226 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf226 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf226 Gene

Domains & Families for C6orf226 Gene

Gene Families for C6orf226 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf226 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf226: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf226 Gene

Function for C6orf226 Gene

Phenotypes From GWAS Catalog for C6orf226 Gene

Gene Ontology (GO) - Molecular Function for C6orf226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C6orf226: view

Phenotypes for C6orf226 Gene

genes like me logo Genes that share phenotypes with C6orf226: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf226 Gene

Localization for C6orf226 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf226 gene
Compartment Confidence
extracellular 3
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf226 Gene

Pathways & Interactions for C6orf226 Gene

SuperPathways for C6orf226 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C6orf226 Gene


No data available for Pathways by source and SIGNOR curated interactions for C6orf226 Gene

Drugs & Compounds for C6orf226 Gene

No Compound Related Data Available

Transcripts for C6orf226 Gene

mRNA/cDNA for C6orf226 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf226 Gene

Chromosome 6 open reading frame 226:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf226 Gene

No ASD Table

Relevant External Links for C6orf226 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C6orf226 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf226 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf226 Gene:


SOURCE GeneReport for Unigene cluster for C6orf226 Gene:

genes like me logo Genes that share expression patterns with C6orf226: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf226 Gene

Orthologs for C6orf226 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for C6orf226 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf226 33
  • 96.97 (n)
C6orf226 34
  • 95 (a)
(Mus musculus)
Mammalia 2310039H08Rik 34
  • 46 (a)
Species where no ortholog for C6orf226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf226 Gene

Gene Tree for C6orf226 (if available)
Gene Tree for C6orf226 (if available)

Paralogs for C6orf226 Gene

No data available for Paralogs for C6orf226 Gene

Variants for C6orf226 Gene

Sequence variations from dbSNP and Humsavar for C6orf226 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000382508 -- 42,892,536(-) G/A upstream_transcript_variant
rs1002628128 -- 42,890,939(-) T/A upstream_transcript_variant
rs1003223887 -- 42,889,812(-) C/T downstream_transcript_variant
rs1004055453 -- 42,890,707(-) C/A/G coding_sequence_variant, missense_variant
rs1004986807 -- 42,891,007(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf226 Gene

Variant ID Type Subtype PubMed ID
esv3576145 CNV gain 25503493
nsv1017398 CNV gain 25217958
nsv830651 CNV loss 17160897

Variation tolerance for C6orf226 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf226 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf226 Gene

Disorders for C6orf226 Gene

Additional Disease Information for C6orf226

No disorders were found for C6orf226 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf226 Gene

Publications for C6orf226 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C6orf226 Gene

Sources for C6orf226 Gene

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