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Aliases for C6orf222 Gene

Aliases for C6orf222 Gene

  • Chromosome 6 Open Reading Frame 222 2 3 5
  • Uncharacterized Protein C6orf222 3

External Ids for C6orf222 Gene

Previous GeneCards Identifiers for C6orf222 Gene

  • GC06M036393
  • GC06M036283
  • GC06M036002
  • GC06M036432
  • GC06M036434
  • GC06M036677
  • GC06M037029
  • GC06M037379
  • GC06M037735
  • GC06M038082

Summaries for C6orf222 Gene

GeneCards Summary for C6orf222 Gene

C6orf222 (Chromosome 6 Open Reading Frame 222) is a Protein Coding gene.

Additional gene information for C6orf222 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf222 Gene

Genomics for C6orf222 Gene

GeneHancer (GH) Regulatory Elements for C6orf222 Gene

Promoters and enhancers for C6orf222 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J036333 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 650.7 +1.4 1412 4.2 ATF1 PKNOX1 CLOCK FOXA2 SIN3A FEZF1 SCRT2 ATF7 CREM IKZF2 C6orf222 LOC105375036
GH06J036357 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -21.6 -21551 1.4 HDGF PKNOX1 STAT5A BMI1 BATF KLF5 IRF4 ATF7 IKZF2 RUNX3 C6orf222 ETV7 LOC105375037 FGD2 MAPK13 KCTD20 PXT1 PNPLA1 CPNE5 PIR35042
GH06J036289 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.9 +45.6 45625 3 PKNOX1 ZNF766 FOS ATF7 ZNF623 ATF4 SMARCA4 NBN KDM1A BRD4 PNPLA1 C6orf222 CLPS BRPF3 MAPK13 LOC105375036
GH06J036422 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -86.6 -86553 2 CLOCK MLX ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 E2F8 ZNF207 ETV7 STK38 KCTD20 MAPK14 SRSF3 ENSG00000237719 LOC105375037 C6orf222 PI16 MAPK13
GH06J036360 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.3 -23.7 -23674 1.1 ELF3 RB1 ARID4B SIN3A KLF5 ZNF48 RAD21 SLC30A9 SCRT2 ZNF143 C6orf222 LOC105375037 ETV7 KCTD20 PXT1 PNPLA1 PIR35042
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C6orf222 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C6orf222 gene promoter:
  • Olf-1
  • C/EBPalpha
  • PPAR-gamma2
  • PPAR-gamma1
  • IRF-1
  • PPAR-alpha
  • ISGF-3
  • HNF-4alpha1
  • IRF-2

Genomic Locations for C6orf222 Gene

Genomic Locations for C6orf222 Gene
chr6:36,315,757-36,336,977
(GRCh38/hg38)
Size:
21,221 bases
Orientation:
Minus strand
chr6:36,283,534-36,304,662
(GRCh37/hg19)
Size:
21,129 bases
Orientation:
Minus strand

Genomic View for C6orf222 Gene

Genes around C6orf222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf222 Gene

Proteins for C6orf222 Gene

  • Protein details for C6orf222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C671-CF222_HUMAN
    Recommended name:
    Uncharacterized protein C6orf222
    Protein Accession:
    P0C671
    Secondary Accessions:
    • B2RTY8

    Protein attributes for C6orf222 Gene

    Size:
    652 amino acids
    Molecular mass:
    71930 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf222 Gene

Post-translational modifications for C6orf222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf222 Gene

No data available for DME Specific Peptides for C6orf222 Gene

Domains & Families for C6orf222 Gene

Gene Families for C6orf222 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf222 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf222: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf222 Gene

Function for C6orf222 Gene

Phenotypes From GWAS Catalog for C6orf222 Gene

Phenotypes for C6orf222 Gene

genes like me logo Genes that share phenotypes with C6orf222: view

Animal Model Products

miRNA for C6orf222 Gene

miRTarBase miRNAs that target C6orf222

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf222 Gene

Localization for C6orf222 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf222 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C6orf222 Gene

Pathways & Interactions for C6orf222 Gene

SuperPathways for C6orf222 Gene

No Data Available

Interacting Proteins for C6orf222 Gene

Gene Ontology (GO) - Biological Process for C6orf222 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf222 Gene

Drugs & Compounds for C6orf222 Gene

No Compound Related Data Available

Transcripts for C6orf222 Gene

mRNA/cDNA for C6orf222 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf222 Gene

Chromosome 6 open reading frame 222:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf222 Gene

No ASD Table

Relevant External Links for C6orf222 Gene

GeneLoc Exon Structure for
C6orf222
ECgene alternative splicing isoforms for
C6orf222

Expression for C6orf222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf222 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf222 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x20.4), Colon - Transverse (x10.2), Stomach (x10.0), and Pancreas (x4.6).

Protein differential expression in normal tissues from HIPED for C6orf222 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (61.3) and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf222 Gene



Protein tissue co-expression partners for C6orf222 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf222 Gene:

C6orf222

SOURCE GeneReport for Unigene cluster for C6orf222 Gene:

Hs.162104
genes like me logo Genes that share expression patterns with C6orf222: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf222 Gene

Orthologs for C6orf222 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf222 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf222 33
  • 99.13 (n)
C6orf222 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf222 33
  • 76.38 (n)
C6orf222 34
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C23H6orf222 33
  • 76.25 (n)
C6orf222 34
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930539E08Rik 16 34 33
  • 66.61 (n)
rat
(Rattus norvegicus)
Mammalia LOC689561 33
  • 65.29 (n)
Species where no ortholog for C6orf222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf222 Gene

ENSEMBL:
Gene Tree for C6orf222 (if available)
TreeFam:
Gene Tree for C6orf222 (if available)

Paralogs for C6orf222 Gene

No data available for Paralogs for C6orf222 Gene

Variants for C6orf222 Gene

Sequence variations from dbSNP and Humsavar for C6orf222 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs193920980 uncertain-significance, Malignant tumor of prostate 36,323,317(-) G/A coding_sequence_variant, missense_variant
rs1000135192 -- 36,338,824(-) C/G upstream_transcript_variant
rs1000248396 -- 36,326,806(-) A/G intron_variant
rs1000512093 -- 36,315,837(-) C/G 3_prime_UTR_variant
rs1000640586 -- 36,321,973(-) G/T intron_variant

Variation tolerance for C6orf222 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.50; 91.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf222 Gene

Human Gene Mutation Database (HGMD)
C6orf222
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C6orf222 Gene

Disorders for C6orf222 Gene

Additional Disease Information for C6orf222

No disorders were found for C6orf222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf222 Gene

Publications for C6orf222 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  2. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4 58
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for C6orf222 Gene

Sources for C6orf222 Gene

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