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Aliases for C6orf15 Gene

Aliases for C6orf15 Gene

  • Chromosome 6 Open Reading Frame 15 2 3 5
  • STG 3 4
  • Uncharacterized Protein C6orf15 3
  • Taste Bud-Specific Protein 3
  • Protein STG 4

External Ids for C6orf15 Gene

Previous GeneCards Identifiers for C6orf15 Gene

  • GC06M031135
  • GC06M030849
  • GC06M031185
  • GC06M031186

Summaries for C6orf15 Gene

GeneCards Summary for C6orf15 Gene

C6orf15 (Chromosome 6 Open Reading Frame 15) is a Protein Coding gene. Diseases associated with C6orf15 include Posterior Cerebral Artery Infarction and Gastric Body Carcinoma. Gene Ontology (GO) annotations related to this gene include heparin binding and fibronectin binding.

Additional gene information for C6orf15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf15 Gene

Genomics for C6orf15 Gene

GeneHancer (GH) Regulatory Elements for C6orf15 Gene

Promoters and enhancers for C6orf15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031112 Promoter 0.7 EPDnew 550.8 0.0 -35 0.1 SCRT1 SCRT2 C6orf15 PSORS1C2 PSORS1C1
GH06I030792 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +318.7 318704 2.1 ELF3 ZBTB40 RARA ZNF207 ATF7 IKZF2 RUNX3 SMARCA5 ZBTB11 ELF1 IER3 VARS2 FLOT1 LINC00243 DDR1-AS1 DDR1 GTF2H4 HCG20 DPCR1 HLA-E
GH06I031079 Enhancer 1 Ensembl ENCODE 12 +32.7 32710 0.5 ELF3 MEIS2 CTCF ETV1 TEAD4 RAD21 ZNF335 CTBP1 GATA3 MTA3 HCG22 PSORS1C2 PSORS1C1 C6orf15 CDSN GTF2H4 VARS2 DDR1 DDR1-AS1 DPCR1
GH06I031072 Enhancer 0.9 Ensembl ENCODE 12 +40.0 39992 0.7 ZNF449 FEZF1 ZIC2 ZNF2 HIC1 ZFHX2 ZNF366 GLI2 PATZ1 PRDM10 HCG22 C6orf15 PSORS1C1 CDSN VARS2 GTF2H4 DDR1 HCG21 DDR1-AS1 DPCR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C6orf15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C6orf15 gene promoter:

Genomic Locations for C6orf15 Gene

Genomic Locations for C6orf15 Gene
1,337 bases
Minus strand

Genomic View for C6orf15 Gene

Genes around C6orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for C6orf15 Gene

  • Protein details for C6orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C6orf15
    Protein Accession:
    Secondary Accessions:
    • B0S7V8
    • Q0EFA6
    • Q2L6G7
    • Q5SQ81
    • Q86Z05
    • Q9UIG3

    Protein attributes for C6orf15 Gene

    325 amino acids
    Molecular mass:
    34195 Da
    Quaternary structure:
    • Binds to numerous extracellular matrix proteins.

neXtProt entry for C6orf15 Gene

Post-translational modifications for C6orf15 Gene

No Post-translational modifications

Other Protein References for C6orf15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf15 Gene

Domains & Families for C6orf15 Gene

Gene Families for C6orf15 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C6orf15 Gene


Suggested Antigen Peptide Sequences for C6orf15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf15: view

No data available for UniProtKB/Swiss-Prot for C6orf15 Gene

Function for C6orf15 Gene

Phenotypes From GWAS Catalog for C6orf15 Gene

Gene Ontology (GO) - Molecular Function for C6orf15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C6orf15: view
genes like me logo Genes that share phenotypes with C6orf15: view

Animal Models for C6orf15 Gene

MGI Knock Outs for C6orf15:

Animal Model Products

CRISPR Products

miRNA for C6orf15 Gene

miRTarBase miRNAs that target C6orf15

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C6orf15 Gene

Localization for C6orf15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf15 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf15 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C6orf15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with C6orf15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C6orf15 Gene

Pathways & Interactions for C6orf15 Gene

SuperPathways for C6orf15 Gene

No Data Available

Interacting Proteins for C6orf15 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000259870 Q6UXA7-CF015_HUMAN for C6orf15 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C6orf15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C6orf15: view

No data available for Pathways by source and SIGNOR curated interactions for C6orf15 Gene

Drugs & Compounds for C6orf15 Gene

No Compound Related Data Available

Transcripts for C6orf15 Gene

mRNA/cDNA for C6orf15 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf15 Gene

Chromosome 6 open reading frame 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf15 Gene

No ASD Table

Relevant External Links for C6orf15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C6orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C6orf15 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x23.3), Skin - Not Sun Exposed (Suprapubic) (x13.5), Cervix - Endocervix (x4.6), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for C6orf15 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf15 Gene

Protein tissue co-expression partners for C6orf15 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf15 Gene:


SOURCE GeneReport for Unigene cluster for C6orf15 Gene:


mRNA Expression by UniProt/SwissProt for C6orf15 Gene:

Tissue specificity: Expressed in skin and tonsils.

Evidence on tissue expression from TISSUES for C6orf15 Gene

  • Skin(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with C6orf15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf15 Gene

Orthologs for C6orf15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf15 33 34
  • 98.77 (n)
(Canis familiaris)
Mammalia C12H6orf15 33
  • 78.35 (n)
C6ORF15 34
  • 66 (a)
(Bos Taurus)
Mammalia C23H6orf15 33
  • 77.82 (n)
C6orf15 34
  • 64 (a)
(Rattus norvegicus)
Mammalia RGD1562885 33
  • 69.58 (n)
(Mus musculus)
Mammalia 2300002M23Rik 33 16 34
  • 66.43 (n)
Species where no ortholog for C6orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf15 Gene

Gene Tree for C6orf15 (if available)
Gene Tree for C6orf15 (if available)

Paralogs for C6orf15 Gene

No data available for Paralogs for C6orf15 Gene

Variants for C6orf15 Gene

Sequence variations from dbSNP and Humsavar for C6orf15 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1002033998 -- 31,113,456(-) A/G upstream_transcript_variant
rs1003765652 -- 31,114,460(-) C/T upstream_transcript_variant
rs1003858589 -- 31,114,414(-) A/G upstream_transcript_variant
rs1004570788 -- 31,111,154(-) C/T downstream_transcript_variant
rs1004878611 -- 31,113,115(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf15 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV deletion 23290073
esv2759414 CNV gain+loss 17122850
esv3411275 CNV duplication 20981092
nsv1033227 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv428140 CNV gain+loss 18775914
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv601489 CNV loss 21841781
nsv601490 CNV gain 21841781

Variation tolerance for C6orf15 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.08; 80.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf15 Gene

Disorders for C6orf15 Gene

MalaCards: The human disease database

(4) MalaCards diseases for C6orf15 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
posterior cerebral artery infarction
  • infarction, posterior cerebral artery
gastric body carcinoma
  • cancer of body of stomach
avoidant personality disorder
  • anxious personality disorder
toxic diffuse goiter
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C6orf15

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with C6orf15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C6orf15 Gene

Publications for C6orf15 Gene

  1. STG does not associate with psoriasis in the Swedish population. (PMID: 15217361) Sánchez F … Ståhle M (Experimental dermatology 2004) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. (PMID: 10545595) Oka A … Inoko H (Human molecular genetics 1999) 3 4 58
  5. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PMID: 23263863) Li J … Sleiman PM (Human molecular genetics 2013) 3 58

Products for C6orf15 Gene

Sources for C6orf15 Gene

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