Aliases for C6orf141 Gene

Aliases for C6orf141 Gene

  • Chromosome 6 Open Reading Frame 141 2 3 5
  • Uncharacterized Protein C6orf141 3 4
  • C6orf141 5
  • MGC46457 2

External Ids for C6orf141 Gene

Previous GeneCards Identifiers for C6orf141 Gene

  • GC06P049519
  • GC06P049565
  • GC06P049626
  • GC06P049247

Summaries for C6orf141 Gene

GeneCards Summary for C6orf141 Gene

C6orf141 (Chromosome 6 Open Reading Frame 141) is a Protein Coding gene.

Additional gene information for C6orf141 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C6orf141 Gene

Genomics for C6orf141 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C6orf141 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C6orf141 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C6orf141

Top Transcription factor binding sites by QIAGEN in the C6orf141 gene promoter:
  • aMEF-2
  • Brachyury
  • CP2
  • MEF-2
  • MEF-2A
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx2-5
  • TBP

Genomic Locations for C6orf141 Gene

Genomic Locations for C6orf141 Gene
chr6:49,550,644-49,561,913
(GRCh38/hg38)
Size:
11,270 bases
Orientation:
Plus strand
chr6:49,518,113-49,529,620
(GRCh37/hg19)
Size:
11,508 bases
Orientation:
Plus strand

Genomic View for C6orf141 Gene

Genes around C6orf141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf141 Gene

Proteins for C6orf141 Gene

  • Protein details for C6orf141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SZD1-CF141_HUMAN
    Recommended name:
    Uncharacterized protein C6orf141
    Protein Accession:
    Q5SZD1
    Secondary Accessions:
    • A8K1H4
    • Q8N400
    • Q96NQ1

    Protein attributes for C6orf141 Gene

    Size:
    244 amino acids
    Molecular mass:
    26754 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36917.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for C6orf141 Gene

Post-translational modifications for C6orf141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C6orf141 Gene

Domains & Families for C6orf141 Gene

Gene Families for C6orf141 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf141 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C6orf141: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C6orf141 Gene

Function for C6orf141 Gene

Phenotypes for C6orf141 Gene

GenomeRNAi human phenotypes for C6orf141:
genes like me logo Genes that share phenotypes with C6orf141: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C6orf141

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf141 Gene

Localization for C6orf141 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C6orf141 Gene

Pathways & Interactions for C6orf141 Gene

PathCards logo

SuperPathways for C6orf141 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C6orf141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001835 blastocyst hatching IBA 21873635
genes like me logo Genes that share ontologies with C6orf141: view

No data available for Pathways by source and SIGNOR curated interactions for C6orf141 Gene

Drugs & Compounds for C6orf141 Gene

No Compound Related Data Available

Transcripts for C6orf141 Gene

mRNA/cDNA for C6orf141 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C6orf141

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf141 Gene

No ASD Table

Relevant External Links for C6orf141 Gene

GeneLoc Exon Structure for
C6orf141

Expression for C6orf141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C6orf141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C6orf141 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.4), Brain - Putamen (basal ganglia) (x6.2), and Brain - Caudate (basal ganglia) (x5.8).

Protein differential expression in normal tissues from HIPED for C6orf141 Gene

This gene is overexpressed in Plasma (56.1) and Heart (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf141 Gene



Protein tissue co-expression partners for C6orf141 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C6orf141

SOURCE GeneReport for Unigene cluster for C6orf141 Gene:

Hs.722010

Evidence on tissue expression from TISSUES for C6orf141 Gene

  • Lung(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with C6orf141: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf141 Gene

Orthologs for C6orf141 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf141 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C6H6orf141 30
  • 98.91 (n)
C6orf141 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C23H6orf141 30 31
  • 72.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC688459 30
  • 65.92 (n)
Mouse
(Mus musculus)
Mammalia 9130008F23Rik 30 17 31
  • 64.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C6orf141 31
  • 47 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C6orf141 31
  • 38 (a)
OneToOne
Species where no ortholog for C6orf141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C6orf141 Gene

ENSEMBL:
Gene Tree for C6orf141 (if available)
TreeFam:
Gene Tree for C6orf141 (if available)

Paralogs for C6orf141 Gene

No data available for Paralogs for C6orf141 Gene

Variants for C6orf141 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C6orf141 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs6919674 - p.Gln137Glu
rs9473588 - p.Pro235Leu

Additional dbSNP identifiers (rs#s) for C6orf141 Gene

Structural Variations from Database of Genomic Variants (DGV) for C6orf141 Gene

Variant ID Type Subtype PubMed ID
dgv5960n100 CNV gain 25217958

Variation tolerance for C6orf141 Gene

Gene Damage Index Score: 4.76; 66.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf141 Gene

Disorders for C6orf141 Gene

No disorders were found for C6orf141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf141 Gene

Publications for C6orf141 Gene

  1. Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer. (PMID: 30872783) Yang CM … Tsai KW (Scientific reports 2019) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for C6orf141 Gene

Sources for C6orf141 Gene