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Aliases for C6orf136 Gene

Aliases for C6orf136 Gene

  • Chromosome 6 Open Reading Frame 136 2 3 5

External Ids for C6orf136 Gene

Previous GeneCards Identifiers for C6orf136 Gene

  • GC06P030385
  • GC06P030721
  • GC06P030722
  • GC06P030614
  • GC06P030414
  • GC06P030648
  • GC06P030658
  • GC06P030816
  • GC06P030806
  • GC06P030902
  • GC06P031063

Summaries for C6orf136 Gene

GeneCards Summary for C6orf136 Gene

C6orf136 (Chromosome 6 Open Reading Frame 136) is a Protein Coding gene.

Additional gene information for C6orf136 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf136 Gene

Genomics for C6orf136 Gene

GeneHancer (GH) Regulatory Elements for C6orf136 Gene

Promoters and enhancers for C6orf136 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030645 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.9 +0.3 253 2.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 C6orf136 HLA-L PRR3 NRM HCG18 HLA-T MICA ATAT1 DHX16
GH06I030678 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +38.3 38287 13.5 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 NRM PPP1R10 DHX16 MDC1 DDX39B TRIM39 LY6G5B IER3 TRIM26 PAIP1P1
GH06I030757 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.3 +117.3 117280 14 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF263 IER3 VARS2 MDC1 PPP1R10 DDR1 C6orf136 PPP1R18 MSH5 FLOT1 HCG4P3
GH06I030746 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +104.4 104388 9.5 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZNF766 FOS DEK RN7SL353P MDC1 IER3 GTF2H4 PAIP1P1 LY6G5B DHX16 DDX39B TRIM39 PPP1R10
GH06I030611 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.8 -31.5 -31487 8.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP1R10 MRPS18B DDX39B MDC1 TRIM39 ABCF1 NRM DHX16 ZNRD1 TRIM26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C6orf136 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C6orf136 gene promoter:

Genomic Locations for C6orf136 Gene

Genomic Locations for C6orf136 Gene
chr6:30,647,039-30,653,210
(GRCh38/hg38)
Size:
6,172 bases
Orientation:
Plus strand
chr6:30,614,816-30,620,987
(GRCh37/hg19)

Genomic View for C6orf136 Gene

Genes around C6orf136 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf136 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for C6orf136 Gene

  • Protein details for C6orf136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SQH8-CF136_HUMAN
    Recommended name:
    Uncharacterized protein C6orf136
    Protein Accession:
    Q5SQH8
    Secondary Accessions:
    • A9R9P9
    • F8VX15
    • Q5SU01
    • Q6ZSB7
    • Q8TB84

    Protein attributes for C6orf136 Gene

    Size:
    315 amino acids
    Molecular mass:
    35794 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI17760.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41881.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95540.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95541.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C6orf136 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf136 Gene

Post-translational modifications for C6orf136 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C6orf136 Gene

Domains & Families for C6orf136 Gene

Gene Families for C6orf136 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C6orf136 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf136: view

No data available for UniProtKB/Swiss-Prot for C6orf136 Gene

Function for C6orf136 Gene

Phenotypes From GWAS Catalog for C6orf136 Gene

genes like me logo Genes that share phenotypes with C6orf136: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf136 Gene

Localization for C6orf136 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf136 gene
Compartment Confidence
mitochondrion 2
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for C6orf136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C6orf136: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for C6orf136 Gene

Pathways & Interactions for C6orf136 Gene

SuperPathways for C6orf136 Gene

No Data Available

Interacting Proteins for C6orf136 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000293604%0d%0a9606.ENSP00000281708%0d%0a
Selected Interacting proteins: Q5SQH8-CF136_HUMAN ENSP00000293604 for C6orf136 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for C6orf136 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf136 Gene

Drugs & Compounds for C6orf136 Gene

No Compound Related Data Available

Transcripts for C6orf136 Gene

Unigene Clusters for C6orf136 Gene

Chromosome 6 open reading frame 136:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf136 Gene

No ASD Table

Relevant External Links for C6orf136 Gene

GeneLoc Exon Structure for
C6orf136
ECgene alternative splicing isoforms for
C6orf136

Expression for C6orf136 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf136 Gene

Protein differential expression in normal tissues from HIPED for C6orf136 Gene

This gene is overexpressed in Frontal cortex (19.3), Retina (11.5), Salivary gland (10.3), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf136 Gene



NURSA nuclear receptor signaling pathways regulating expression of C6orf136 Gene:

C6orf136

SOURCE GeneReport for Unigene cluster for C6orf136 Gene:

Hs.591787

Evidence on tissue expression from TISSUES for C6orf136 Gene

  • Eye(3.4)
genes like me logo Genes that share expression patterns with C6orf136: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf136 Gene

Orthologs for C6orf136 Gene

This gene was present in the common ancestor of animals.

Orthologs for C6orf136 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6orf136 34
  • 100 (a)
OneToOne
C6H6orf136 33
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia C12H6orf136 33
  • 89.1 (n)
C6orf136 34
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6orf136 34
  • 89 (a)
OneToOne
C23H6orf136 33
  • 88.64 (n)
mouse
(Mus musculus)
Mammalia 2310061I04Rik 33 16 34
  • 83.23 (n)
rat
(Rattus norvegicus)
Mammalia RGD1302996 33
  • 81.83 (n)
oppossum
(Monodelphis domestica)
Mammalia C6orf136 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf136 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf136 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf136 33
  • 50.72 (n)
zebrafish
(Danio rerio)
Actinopterygii C19H6orf136 34
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16787 34
  • 26 (a)
OneToOne
Species where no ortholog for C6orf136 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C6orf136 Gene

ENSEMBL:
Gene Tree for C6orf136 (if available)
TreeFam:
Gene Tree for C6orf136 (if available)

Paralogs for C6orf136 Gene

No data available for Paralogs for C6orf136 Gene

Variants for C6orf136 Gene

Sequence variations from dbSNP and Humsavar for C6orf136 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000112654 -- 30,645,603(+) G/C upstream_transcript_variant
rs1000716173 -- 30,646,792(+) G/A upstream_transcript_variant
rs1001025510 -- 30,647,046(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001187589 -- 30,646,836(+) T/C upstream_transcript_variant
rs1001231873 -- 30,646,985(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf136 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for C6orf136 Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf136 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf136

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf136 Gene

Disorders for C6orf136 Gene

Additional Disease Information for C6orf136

No disorders were found for C6orf136 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf136 Gene

Publications for C6orf136 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for C6orf136 Gene

Sources for C6orf136 Gene

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