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Aliases for C6orf132 Gene

Aliases for C6orf132 Gene

  • Chromosome 6 Open Reading Frame 132 2 3 5
  • Uncharacterized Protein C6orf132 3
  • BA7K24.2 3

External Ids for C6orf132 Gene

Previous GeneCards Identifiers for C6orf132 Gene

  • GC00U914215
  • GC06U900651
  • GC06M042185
  • GC06M042202
  • GC06M041786

Summaries for C6orf132 Gene

GeneCards Summary for C6orf132 Gene

C6orf132 (Chromosome 6 Open Reading Frame 132) is a Protein Coding gene.

Additional gene information for C6orf132 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf132 Gene

Genomics for C6orf132 Gene

GeneHancer (GH) Regulatory Elements for C6orf132 Gene

Promoters and enhancers for C6orf132 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I042135 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +3.6 3556 8.8 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF143 C6orf132 GUCA1B RRP36 ENSG00000261068 GC06P042354
GH06I042115 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.4 +22.2 22166 10.1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF48 YY1 ZNF121 ZNF207 C6orf132 ENSG00000214732 GUCA1A GUCA1B MED20 ENSG00000207371 BYSL ENSG00000206977 ENSG00000261068 GC06P042354
GH06I042097 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.1 +40.1 40117 11.2 HDGF HNRNPUL1 PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A SLC30A9 ZNF766 RRP36 C6orf132 UBR2 BICRAL GUCA1A ENSG00000214732 GUCA1B ENSG00000261068 FRS3 PRICKLE4
GH06I042112 Enhancer 0.9 ENCODE dbSUPER 26.9 +29.3 29262 2.8 LEF1 CEBPG ZFHX2 TRIM24 FOS HES1 EGR2 TCF7L2 ZNF362 SOX6 C6orf132 GUCA1A ENSG00000214732 GUCA1B MED20 ENSG00000207371 BYSL ENSG00000261068 GC06P042354
GH06I042223 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 -83.8 -83825 5.9 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B IRF4 FOS PIR36094 MRPS10 GUCA1B GUCA1A ENSG00000214732 C6orf132 TRERF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C6orf132 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C6orf132 gene promoter:

Genomic Locations for C6orf132 Gene

Genomic Locations for C6orf132 Gene
chr6:42,101,118-42,142,977
(GRCh38/hg38)
Size:
41,860 bases
Orientation:
Minus strand
chr6:42,068,856-42,110,715
(GRCh37/hg19)

Genomic View for C6orf132 Gene

Genes around C6orf132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf132 Gene

Proteins for C6orf132 Gene

  • Protein details for C6orf132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0Z8-CF132_HUMAN
    Recommended name:
    Uncharacterized protein C6orf132
    Protein Accession:
    Q5T0Z8
    Secondary Accessions:
    • A6NI05

    Protein attributes for C6orf132 Gene

    Size:
    1188 amino acids
    Molecular mass:
    124034 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BE791477; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BU857282; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BU857282; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=CAI16783.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19541.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C6orf132 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf132 Gene

Post-translational modifications for C6orf132 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf132 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf132 Gene

Domains & Families for C6orf132 Gene

Gene Families for C6orf132 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf132 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf132: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf132 Gene

Function for C6orf132 Gene

Phenotypes From GWAS Catalog for C6orf132 Gene

genes like me logo Genes that share phenotypes with C6orf132: view

Animal Model Products

miRNA for C6orf132 Gene

miRTarBase miRNAs that target C6orf132

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf132 Gene

Localization for C6orf132 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf132 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf132 Gene

Pathways & Interactions for C6orf132 Gene

SuperPathways for C6orf132 Gene

No Data Available

Interacting Proteins for C6orf132 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341368%0d%0a9606.ENSP00000216492%0d%0a9606.ENSP00000441929%0d%0a9606.ENSP00000341551%0d%0a9606.ENSP00000344666%0d%0a
Selected Interacting proteins: ENSP00000341368 for C6orf132 Gene via STRING

Gene Ontology (GO) - Biological Process for C6orf132 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf132 Gene

Drugs & Compounds for C6orf132 Gene

No Compound Related Data Available

Transcripts for C6orf132 Gene

mRNA/cDNA for C6orf132 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf132 Gene

Chromosome 6 open reading frame 132:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf132 Gene

No ASD Table

Relevant External Links for C6orf132 Gene

GeneLoc Exon Structure for
C6orf132
ECgene alternative splicing isoforms for
C6orf132

Expression for C6orf132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf132 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf132 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.8), Skin - Sun Exposed (Lower leg) (x6.3), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for C6orf132 Gene

This gene is overexpressed in Cervix (34.2), Bone (12.9), and Hair follicle (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf132 Gene



NURSA nuclear receptor signaling pathways regulating expression of C6orf132 Gene:

C6orf132

SOURCE GeneReport for Unigene cluster for C6orf132 Gene:

Hs.444277
genes like me logo Genes that share expression patterns with C6orf132: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf132 Gene

Orthologs for C6orf132 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf132 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf132 33
  • 98.89 (n)
C6orf132 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6orf132 34
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI661453 34
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6orf132 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf132 34
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C6orf132 34
  • 26 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6orf132 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf132 34
  • 47 (a)
OneToOne
Species where no ortholog for C6orf132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf132 Gene

ENSEMBL:
Gene Tree for C6orf132 (if available)
TreeFam:
Gene Tree for C6orf132 (if available)

Paralogs for C6orf132 Gene

No data available for Paralogs for C6orf132 Gene

Variants for C6orf132 Gene

Sequence variations from dbSNP and Humsavar for C6orf132 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000091995 -- 42,129,205(-) A/G intron_variant
rs1000168309 -- 42,131,768(-) T/C intron_variant
rs1000176416 -- 42,101,556(-) A/T 3_prime_UTR_variant
rs1000188940 -- 42,121,238(-) G/A intron_variant
rs1000268462 -- 42,104,892(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf132 Gene

Variant ID Type Subtype PubMed ID
dgv10639n54 CNV loss 21841781
dgv753n27 CNV loss 19166990
esv2658537 CNV deletion 23128226
nsv830649 CNV loss 17160897

Variation tolerance for C6orf132 Gene

Gene Damage Index Score: 8.73; 86.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf132 Gene

Human Gene Mutation Database (HGMD)
C6orf132
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf132 Gene

Disorders for C6orf132 Gene

Additional Disease Information for C6orf132

No disorders were found for C6orf132 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf132 Gene

Publications for C6orf132 Gene

  1. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T … Xu R (Neurobiology of aging 2014) 3 58
  2. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z … Zaidel-Bar R (Science signaling 2014) 3 58
  3. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A … Comb MJ (Molecular & cellular proteomics : MCP 2014) 4 58
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 58

Products for C6orf132 Gene

Sources for C6orf132 Gene

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