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Aliases for C6orf106 Gene

Aliases for C6orf106 Gene

  • Chromosome 6 Open Reading Frame 106 2 3 5
  • Uncharacterized Protein C6orf106 3
  • DJ391O22.4 3
  • FP852 3

External Ids for C6orf106 Gene

Previous GeneCards Identifiers for C6orf106 Gene

  • GC06M034601
  • GC06M034663
  • GC06M034278
  • GC06M034689
  • GC06M034899
  • GC06M035237
  • GC06M035732
  • GC06M034815
  • GC06M035575
  • GC06M036290
  • GC06M036659
  • GC06M037012
  • GC06M037362
  • GC06M037718
  • GC06M038064

Summaries for C6orf106 Gene

GeneCards Summary for C6orf106 Gene

C6orf106 (Chromosome 6 Open Reading Frame 106) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin binding.

Additional gene information for C6orf106 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf106 Gene

Genomics for C6orf106 Gene

GeneHancer (GH) Regulatory Elements for C6orf106 Gene

Promoters and enhancers for C6orf106 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J034694 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.6 603 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 C6orf106 LOC101929243 GC06P043186 TAF11 LEMD2 UHRF1BP1 RPL10A ZNF76 RPS10 ENSG00000219023
GH06J034655 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +39.4 39393 4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 ZNF2 UHRF1BP1 TAF11 LEMD2 ENSG00000220643 C6orf106 ENSG00000219023 FANCE RPS10 RPL10A HMGA1
GH06J034663 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +32.4 32401 3.4 HDGF PKNOX1 ATF1 FOXA2 ARNT ETS1 YY1 ZNF766 E2F8 ATF7 UHRF1BP1 ENSG00000220643 C6orf106 FANCE HMGA1 GC06M038525 RN7SL200P GC06P043158
GH06J035341 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.3 -646.4 -646389 3.2 HDGF HNRNPUL1 PKNOX1 MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 PPARD FANCE TAF11 FKBP5 RPS10 RPL10A TEAD3 BRPF3 ENSG00000219023 MAPK14
GH06J034608 Enhancer 1.2 Ensembl ENCODE 11.1 +86.5 86544 2.7 HDGF PKNOX1 FOXA2 MLX ARNT ZNF2 YY1 ZNF213 E2F8 ZNF143 UHRF1BP1 RPL10A SPDEF ENSG00000219023 RPS10 ENSG00000220643 C6orf106 LEMD2 GRM4 ANKS1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C6orf106 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C6orf106 gene promoter:
  • Max1
  • STAT5A
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • p53
  • CRE-BP1
  • ATF-2
  • C/EBPalpha
  • CREB

Genomic Locations for C6orf106 Gene

Genomic Locations for C6orf106 Gene
chr6:34,587,280-34,696,859
(GRCh38/hg38)
Size:
109,580 bases
Orientation:
Minus strand
chr6:34,555,065-34,664,636
(GRCh37/hg19)
Size:
109,572 bases
Orientation:
Minus strand

Genomic View for C6orf106 Gene

Genes around C6orf106 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf106 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf106 Gene

Proteins for C6orf106 Gene

  • Protein details for C6orf106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6K1-CF106_HUMAN
    Recommended name:
    Uncharacterized protein C6orf106
    Protein Accession:
    Q9H6K1
    Secondary Accessions:
    • B2R8K7
    • Q5VV77
    • Q96MG5
    • Q9BUR9

    Protein attributes for C6orf106 Gene

    Size:
    298 amino acids
    Molecular mass:
    32872 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C6orf106 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf106 Gene

Post-translational modifications for C6orf106 Gene

  • Ubiquitination at posLast=287287, posLast=240240, posLast=228228, Lys218, posLast=205205, and Lys15
  • Modification sites at PhosphoSitePlus

Other Protein References for C6orf106 Gene

Antibody Products

  • Boster Bio Antibodies for C6orf106

No data available for DME Specific Peptides for C6orf106 Gene

Domains & Families for C6orf106 Gene

Gene Families for C6orf106 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf106 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf106: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf106 Gene

Function for C6orf106 Gene

Phenotypes From GWAS Catalog for C6orf106 Gene

Gene Ontology (GO) - Molecular Function for C6orf106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with C6orf106: view
genes like me logo Genes that share phenotypes with C6orf106: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf106 Gene

Localization for C6orf106 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf106 gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C6orf106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA --
GO:0005575 cellular_component ND --
GO:0005776 autophagosome IBA --
genes like me logo Genes that share ontologies with C6orf106: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C6orf106 Gene

Pathways & Interactions for C6orf106 Gene

SuperPathways for C6orf106 Gene

No Data Available

Interacting Proteins for C6orf106 Gene

Gene Ontology (GO) - Biological Process for C6orf106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016236 macroautophagy IBA --
genes like me logo Genes that share ontologies with C6orf106: view

No data available for Pathways by source and SIGNOR curated interactions for C6orf106 Gene

Drugs & Compounds for C6orf106 Gene

No Compound Related Data Available

Transcripts for C6orf106 Gene

mRNA/cDNA for C6orf106 Gene

Unigene Clusters for C6orf106 Gene

Chromosome 6 open reading frame 106:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf106 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: -
SP4: - - -
SP5: - - -
SP6:

Relevant External Links for C6orf106 Gene

GeneLoc Exon Structure for
C6orf106
ECgene alternative splicing isoforms for
C6orf106

Expression for C6orf106 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf106 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf106 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C6orf106 Gene



NURSA nuclear receptor signaling pathways regulating expression of C6orf106 Gene:

C6orf106

SOURCE GeneReport for Unigene cluster for C6orf106 Gene:

Hs.643498

Evidence on tissue expression from TISSUES for C6orf106 Gene

  • Muscle(4.3)
  • Nervous system(4)
  • Eye(2.7)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with C6orf106: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf106 Gene

Orthologs for C6orf106 Gene

This gene was present in the common ancestor of animals.

Orthologs for C6orf106 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6ORF106 34
  • 100 (a)
OneToOne
LOC463186 33
  • 100 (n)
dog
(Canis familiaris)
Mammalia C6orf106 34
  • 99 (a)
OneToOne
C12H6orf106 33
  • 97.02 (n)
cow
(Bos Taurus)
Mammalia C6ORF106 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D17Wsu92e 16 34 33
  • 94.39 (n)
oppossum
(Monodelphis domestica)
Mammalia C6orf106 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf106 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C26H6ORF106 34 33
  • 86.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf106 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf106 33
  • 72.9 (n)
zebrafish
(Danio rerio)
Actinopterygii C6H6orf106 34
  • 81 (a)
OneToOne
zgc:101577 33
  • 76.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000469 33
  • 50.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5445 34
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C36E6.2 34
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5611 34
  • 35 (a)
OneToOne
Species where no ortholog for C6orf106 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C6orf106 Gene

ENSEMBL:
Gene Tree for C6orf106 (if available)
TreeFam:
Gene Tree for C6orf106 (if available)

Paralogs for C6orf106 Gene

Pseudogenes.org Pseudogenes for C6orf106 Gene

genes like me logo Genes that share paralogs with C6orf106: view

No data available for Paralogs for C6orf106 Gene

Variants for C6orf106 Gene

Sequence variations from dbSNP and Humsavar for C6orf106 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000018719 -- 34,635,586(-) A/G intron_variant
rs1000030053 -- 34,631,426(-) C/A intron_variant
rs1000046463 -- 34,644,728(-) G/C intron_variant
rs1000099588 -- 34,604,543(-) A/G intron_variant
rs1000103682 -- 34,622,657(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf106 Gene

Variant ID Type Subtype PubMed ID
nsv981134 CNV duplication 23825009
nsv830640 CNV loss 17160897
nsv823667 CNV gain 20364138
nsv818410 CNV gain 17921354
nsv7888 CNV loss 18304495
nsv5255 CNV deletion 18451855
nsv516578 CNV loss 19592680
nsv1033534 CNV gain 25217958
esv988873 CNV deletion 20482838
esv3608666 CNV loss 21293372
esv3608665 CNV gain 21293372
esv3608664 CNV gain 21293372
esv2763967 CNV gain 21179565
esv2759418 CNV gain 17122850
esv2665867 CNV deletion 23128226
esv1078185 CNV insertion 17803354
dgv5954n100 CNV gain 25217958

Variation tolerance for C6orf106 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf106 Gene

Human Gene Mutation Database (HGMD)
C6orf106
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf106 Gene

Disorders for C6orf106 Gene

Additional Disease Information for C6orf106

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C6orf106 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf106 Gene

Publications for C6orf106 Gene

  1. C6orf106 enhances NSCLC cell invasion by upregulating vimentin, and downregulating E-cadherin and P120ctn. (PMID: 25736925) Zhang X … Wang E (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015) 2 3 58
  2. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N … Deloukas P (PLoS genetics 2009) 3 44 58
  3. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon MN … Frayling TM (Nature genetics 2008) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for C6orf106 Gene

Sources for C6orf106 Gene

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