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Aliases for C6orf58 Gene
Aliases for C6orf58 Gene
External Ids for C6orf58 Gene
- HGNC: 20960
- Entrez Gene: 352999
- Ensembl: ENSG00000184530
- UniProtKB: Q6P5S2
Previous GeneCards Identifiers for C6orf58 Gene
- GC06U900113
- GC06P127941
- GC06P127840
- GC06P125474
Summaries for C6orf58 Gene
GeneCards Summary for C6orf58 Gene
C6orf58 (Chromosome 6 Open Reading Frame 58) is a Protein Coding gene. Diseases associated with C6orf58 include Sparganosis.
UniProtKB/Swiss-Prot Summary for C6orf58 Gene
-
May be involved in early liver development.
Additional gene information for C6orf58 Gene
- HGNC(20960)
- Entrez Gene(352999)
- Ensembl(ENSG00000184530)
- UniProtKB(Q6P5S2)
- Open Targets Platform(ENSG00000184530)
- Search for C6orf58 at DataMed
- Search for C6orf58 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C6orf58 Gene
Genomics for C6orf58 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for C6orf58 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around C6orf58 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C6orf58
- Top Transcription factor binding sites by QIAGEN in the C6orf58 gene promoter:
-
- aMEF-2
- AREB6
- MEF-2A
- NF-kappaB1
- Pax-4a
- RelA
- SRY
- TBP
- TFIID
Genomic Locations for C6orf58 Gene
Genomic Locations for C6orf58 Gene
- chr6:127,519,455-127,591,820
- (GRCh38/hg38)
- Size:
- 72,366 bases
- Orientation:
- Plus strand
- chr6:127,840,600-127,912,962
- (GRCh37/hg19)
- Size:
- 72,363 bases
- Orientation:
- Plus strand
Genomic View for C6orf58 Gene
Genes around C6orf58 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.33 by HGNC
- 6q22.33 by Entrez Gene
- 6q22.33 by Ensembl
C6orf58 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C6orf58 Gene
Proteins for C6orf58 Gene
-
Protein details for C6orf58 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P5S2-LEG1H_HUMAN
- Recommended name:
- Protein LEG1 homolog
- Protein Accession:
- Q6P5S2
- B4E1I0
- Q5VUP2
Protein attributes for C6orf58 Gene
- Size:
- 330 amino acids
- Molecular mass:
- 37926 Da
- Quaternary structure:
- No Data Available
Protein Expression for C6orf58 Gene
Post-translational modifications for C6orf58 Gene
Other Protein References for C6orf58 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- HUABIO Anti-C6orf58 Antibody
-
Custom Antibody ServicesOriGene Antibodies for C6orf58
- Novus Biologicals Antibodies for C6orf58
-
Abcam antibodies for C6orf58
- Invitrogen Antibodies for C6orf58 (AFLGC-C6orf58)
- antibodies-online: Show 10 available C6ORF58 Antibodies ranked by validation data
-
Biorbyt antibodies for C6orf58
Protein Products
-
OriGene Purified Proteins for C6orf58
- Search Origene for MassSpec and Protein Over-expression Lysates for C6orf58
- Origene Custom Protein Services for C6orf58
No data available for DME Specific Peptides for C6orf58 Gene
Domains & Families for C6orf58 Gene
Gene Families for C6orf58 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for C6orf58 Gene
- GenScript: Design optimal peptide antigens:
-
- UPF0762 protein C6orf58 (CF058_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6P5S2- Family:
-
- Belongs to the LEG1 family.
Function for C6orf58 Gene
Molecular function for C6orf58 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in early liver development.
Phenotypes From GWAS Catalog for C6orf58 Gene
Phenotypes for C6orf58 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C6orf58 - Select products 50% OFF >
- * C6orf58 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for C6orf58
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C6orf58
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf58
miRNA for C6orf58 Gene
- miRTarBase miRNAs that target C6orf58
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for C6orf58 - Select products 50% OFF >
- * C6orf58 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C6orf58
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C6orf58
Cell Line Products
-
Horizon Cell Lines for C6orf58
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf58 Gene
Localization for C6orf58 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C6orf58 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA,IDA | 25645918 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for C6orf58 Gene
Pathways & Interactions for C6orf58 Gene
Interacting Proteins for C6orf58 Gene
GPS-Prot Interaction Network for C6orf58
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for C6orf58 Gene
Transcripts for C6orf58 Gene
mRNA/cDNA for C6orf58 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000498112 352 nts (view in UCSC)
- ENST00000329722 1203 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C6orf58 - Select products 50% OFF >
- * C6orf58 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C6orf58
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C6orf58
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf58
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C6orf58
- Browse OriGene Inhibitory RNA Products For C6orf58
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C6orf58
Clone Products
- Applied Biological Materials (abm): Clones for C6orf58 - Select products 50% OFF >
- * C6orf58 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C6orf58
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C6orf58
Relevant External Links for C6orf58 Gene
- GeneLoc Exon Structure for
- C6orf58
Expression for C6orf58 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for C6orf58 Gene
This gene is overexpressed in Minor Salivary Gland (x51.9).
This gene is overexpressed in Pancreatic juice (36.5), Saliva (16.9), and Skin (12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf58 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C6orf58
SOURCE GeneReport for Unigene cluster for C6orf58 Gene:
Hs.226268mRNA Expression by UniProt/SwissProt for C6orf58 Gene:
Q6P5S2-LEG1H_HUMAN
Tissue specificity:
Detected in saliva and in hypomineralized dental enamel (at protein level).
Evidence on tissue expression from TISSUES for C6orf58 Gene
- Saliva(4.2)
- Intestine(2.9)
- Skin(2.7)
- Stomach(2.6)
Primer Products
-
OriGene qPCR primer pairs for C6orf58
-
OriGene qPCR primer pairs and template standards for C6orf58
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf58 Gene
Orthologs for C6orf58 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C6orf58 31 |
|
OneToOne | |
| C6H6orf58 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | C1H6orf58 30 |
|
||
| C6orf58 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | C6orf58 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | 2310057J18Rik 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | C6orf58 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | C6orf58 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | C6orf58 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | C6orf58 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | C20H6orf58 (1 of 2) 31 |
|
OneToMany | |
| C20H6orf58 (2 of 2) 31 |
|
OneToMany |
- Species where no ortholog for C6orf58 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for C6orf58 Gene
Pseudogenes.org Pseudogenes for C6orf58 Gene
No data available for Paralogs for C6orf58 Gene
Variants for C6orf58 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C6orf58 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs9491833 | - | p.Cys308Gly |
Residual Variation Intolerance Score:
68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.26;
40.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C6orf58 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C6orf58
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf58 Gene
Disorders for C6orf58 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sparganosis |
|
|
Search C6orf58 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for C6orf58
No data available for UniProtKB/Swiss-Prot and Genatlas for C6orf58 Gene
Publications for C6orf58 Gene
- Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. (PMID: 26901320) Hu M … Peng J (PLoS genetics 2016) 2 3
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
ExternalLinks
Products for C6orf58 Gene
- Custom Antibody ServicesOriGene Antibodies for C6orf58
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- Custom Assay Services
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- OriGene qPCR primer pairs for C6orf58
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- antibodies-online: Show 10 available C6ORF58 Antibodies ranked by validation data
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- Biorbyt antibodies for C6orf58
Sources for C6orf58 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (55) TGDB
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- (58) Novus Biologicals
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
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- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
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- (152) DiseaseEnhancer
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- (156) Mastermind
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- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB