External Ids for C6 Gene
Previous GeneCards Identifiers for C6 Gene
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
GeneCards Summary for C6 Gene
C6 (Complement C6) is a Protein Coding gene. Diseases associated with C6 include Complement Component 6 Deficiency and Immunodeficiency Due To A Late Component Of Complement Deficiency. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. An important paralog of this gene is C7.
UniProtKB/Swiss-Prot for C6 Gene
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.