Aliases for C5orf66 Gene

Subcategory (RNA class) for C5orf66 Gene

lncRNA

Number of RNA Genes sources:

2 / 14

Aliases for C5orf66 Gene

  • Chromosome 5 Open Reading Frame 66 2 3 5
  • Putative Uncharacterized Protein C5orf66 4
  • Lnc-CATSPER3-2 168
  • HSALNG0045014 167

External Ids for C5orf66 Gene

Previous GeneCards Identifiers for C5orf66 Gene

  • GC05P134373

Summaries for C5orf66 Gene

GeneCards Summary for C5orf66 Gene

C5orf66 (Chromosome 5 Open Reading Frame 66) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for C5orf66 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C5orf66 Gene

Genomics for C5orf66 Gene

GeneHancer (GH) Regulatory Elements for C5orf66 Gene

Promoters and enhancers for C5orf66 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5orf66 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C5orf66

Genomic Locations for C5orf66 Gene

Genomic Locations for C5orf66 Gene
chr5:135,033,274-135,358,219
(GRCh38/hg38)
Size:
324,946 bases
Orientation:
Plus strand
chr5:134,368,970-134,691,744
(GRCh37/hg19)
Size:
322,775 bases
Orientation:
Plus strand

Genomic View for C5orf66 Gene

Genes around C5orf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf66 Gene

Proteins for C5orf66 Gene

  • Protein details for C5orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5L9-CE066_HUMAN
    Recommended name:
    Putative uncharacterized protein C5orf66
    Protein Accession:
    Q9H5L9

    Protein attributes for C5orf66 Gene

    Size:
    145 amino acids
    Molecular mass:
    15570 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf66 Gene

Post-translational modifications for C5orf66 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C5orf66 Gene

Domains & Families for C5orf66 Gene

Protein Domains for C5orf66 Gene

ProtoNet:
genes like me logo Genes that share domains with C5orf66: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C5orf66 Gene

Function for C5orf66 Gene

Phenotypes From GWAS Catalog for C5orf66 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf66

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf66 Gene

Localization for C5orf66 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf66 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C5orf66 Gene

Pathways & Interactions for C5orf66 Gene

PathCards logo

SuperPathways for C5orf66 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for C5orf66 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for C5orf66 Gene

Drugs & Compounds for C5orf66 Gene

No Compound Related Data Available

Transcripts for C5orf66 Gene

mRNA/cDNA for C5orf66 Gene

8 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
5 LncBook transcripts :
5 LNCipedia transcripts :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf66

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf66 Gene

No ASD Table

Relevant External Links for C5orf66 Gene

GeneLoc Exon Structure for
C5orf66

Expression for C5orf66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf66 Gene

mRNA differential expression in normal tissues according to GTEx for C5orf66 Gene

This gene is overexpressed in Esophagus - Mucosa (x17.8), Vagina (x7.8), Pituitary (x6.5), Cervix - Ectocervix (x5.1), and Minor Salivary Gland (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C5orf66

genes like me logo Genes that share expression patterns with C5orf66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf66 Gene

Orthologs for C5orf66 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101057750 30
  • 99.77 (n)
C5orf66 31
  • 99 (a)
OneToOne
Species where no ortholog for C5orf66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf66 Gene

ENSEMBL:
Gene Tree for C5orf66 (if available)
TreeFam:
Gene Tree for C5orf66 (if available)

Paralogs for C5orf66 Gene

No data available for Paralogs for C5orf66 Gene

Variants for C5orf66 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C5orf66 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
716117 Benign: not provided 135,343,265(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
745264 Likely Benign: not provided 135,033,807(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for C5orf66 Gene

Structural Variations from Database of Genomic Variants (DGV) for C5orf66 Gene

Variant ID Type Subtype PubMed ID
dgv969n67 CNV gain 20364138
esv1002716 CNV deletion 20482838
esv2658273 CNV deletion 23128226
esv2676443 CNV deletion 23128226
esv275412 CNV loss 21479260
esv3344771 CNV insertion 20981092
esv3353228 CNV duplication 20981092
esv3606855 CNV loss 21293372
esv3606858 CNV loss 21293372
nsv1026820 CNV gain 25217958
nsv1073498 CNV deletion 25765185
nsv1078825 CNV insertion 25765185
nsv1123985 CNV deletion 24896259
nsv1129749 CNV tandem duplication 24896259
nsv327970 CNV insertion 16902084
nsv329851 CNV insertion 16902084
nsv462458 CNV loss 19166990
nsv5014 CNV insertion 18451855
nsv5015 CNV insertion 18451855
nsv518218 CNV loss 19592680
nsv519790 CNV gain 19592680
nsv599744 CNV loss 21841781
nsv599745 CNV loss 21841781
nsv823239 CNV gain 20364138
nsv823240 CNV gain 20364138
nsv823243 CNV gain 20364138
nsv830495 CNV loss 17160897
nsv830496 CNV gain 17160897
nsv950398 CNV deletion 24416366
nsv950399 CNV deletion 24416366
nsv950400 CNV deletion 24416366

Variation tolerance for C5orf66 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf66 Gene

Disorders for C5orf66 Gene

Additional Disease Information for C5orf66

No disorders were found for C5orf66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf66 Gene

Publications for C5orf66 Gene

  1. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. (PMID: 24836286) Zhang B … Zheng W (Nature genetics 2014) 3 54
  2. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. (PMID: 23263487) Jia WH … Zheng W (Nature genetics 2013) 3 54
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 54
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L … Cho JH (Nature 2012) 3 54
  5. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. (PMID: 22658931) Pajewski NM … Kaslow RA (Vaccine 2012) 3 54

Products for C5orf66 Gene

Sources for C5orf66 Gene