Aliases for C5orf64 Gene

Subcategory (RNA class) for C5orf64 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for C5orf64 Gene

  • Chromosome 5 Open Reading Frame 64 2 3 5
  • Uncharacterized Protein C5orf64 3 4
  • NONHSAG040493 92
  • HSALNG0042154 167
  • HSALNG0042160 167
  • Lnc-ZSWIM6-6 168
  • Lnc-ZSWIM6-7 168

External Ids for C5orf64 Gene

Previous GeneCards Identifiers for C5orf64 Gene

  • GC05P060933

Summaries for C5orf64 Gene

GeneCards Summary for C5orf64 Gene

C5orf64 (Chromosome 5 Open Reading Frame 64) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with C5orf64 include Waardenburg Syndrome, Type 1.

Additional gene information for C5orf64 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C5orf64 Gene

Genomics for C5orf64 Gene

GeneHancer (GH) Regulatory Elements for C5orf64 Gene

Promoters and enhancers for C5orf64 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J061609 Enhancer 0.6 Ensembl dbSUPER 500.7 +0.4 377 1.2 EP300 MXI1 POLR2A RAD21 C5orf64 lnc-SMIM15-3
GH05J061672 Enhancer 0.8 Ensembl ENCODE dbSUPER 6.3 +63.7 63677 3.4 EP300 CTCF NR2F2 FOS RAD21 GATA2 C5orf64 RF00026-866 RNU6-913P ENSG00000248529 LOC101928651
GH05J061625 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 3.2 +15.5 15491 2.3 HDAC2 POLR2A NR2F2 YY1 PHF8 MEF2B GABPB1 ETS1 SIN3A EBF1 C5orf64 LOC105378997 lnc-SMIM15-3
GH05J061701 Enhancer 0.4 Ensembl 9.9 +91.6 91577 0.4 ZFHX2 IKZF1 NFIC EGR2 piR-48759-244 RNU6-913P C5orf64 ENSG00000248529 LOC101928651 lnc-SMIM15-7
GH05J061658 Enhancer 0.9 ENCODE dbSUPER 4.3 +48.9 48889 1.4 CTCF TCF12 USF1 GABPA REST RFX1 RAD21 TRIM22 SMC3 DEK C5orf64 HSPD1P22 LOC105378997 ENSG00000248529
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5orf64 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C5orf64

Genomic Locations for C5orf64 Gene

Genomic Locations for C5orf64 Gene
chr5:61,610,424-61,826,485
(GRCh38/hg38)
Size:
216,062 bases
Orientation:
Plus strand
chr5:60,933,535-61,047,590
(GRCh37/hg19)
Size:
114,056 bases
Orientation:
Plus strand

Genomic View for C5orf64 Gene

Genes around C5orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf64 Gene

Proteins for C5orf64 Gene

  • Protein details for C5orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2E5-CE064_HUMAN
    Recommended name:
    Uncharacterized protein C5orf64
    Protein Accession:
    Q2M2E5
    Secondary Accessions:
    • Q2M2H1
    • Q8N1U8

    Protein attributes for C5orf64 Gene

    Size:
    130 amino acids
    Molecular mass:
    14817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf64 Gene

Post-translational modifications for C5orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C5orf64 Gene

Domains & Families for C5orf64 Gene

Protein Domains for C5orf64 Gene

ProtoNet:
genes like me logo Genes that share domains with C5orf64: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C5orf64 Gene

Function for C5orf64 Gene

Phenotypes From GWAS Catalog for C5orf64 Gene

genes like me logo Genes that share phenotypes with C5orf64: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf64 Gene

Localization for C5orf64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf64 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf64 gene
Compartment Confidence
extracellular 4
mitochondrion 3

Gene Ontology (GO) - Cellular Components for C5orf64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C5orf64: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C5orf64 Gene

Pathways & Interactions for C5orf64 Gene

PathCards logo

SuperPathways for C5orf64 Gene

No Data Available

Interacting Proteins for C5orf64 Gene

Selected Interacting proteins: Q2M2E5-CE064_HUMAN for C5orf64 Gene via IID

Symbol External ID(s) Details
H2AX
OXLD1
;

Gene Ontology (GO) - Biological Process for C5orf64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf64 Gene

Drugs & Compounds for C5orf64 Gene

No Compound Related Data Available

Transcripts for C5orf64 Gene

mRNA/cDNA for C5orf64 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf64 Gene

No ASD Table

Relevant External Links for C5orf64 Gene

GeneLoc Exon Structure for
C5orf64

Expression for C5orf64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf64 Gene

mRNA differential expression in normal tissues according to GTEx for C5orf64 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.7), Brain - Substantia nigra (x7.5), Brain - Hippocampus (x4.6), Brain - Putamen (basal ganglia) (x4.5), Brain - Hypothalamus (x4.5), and Brain - Amygdala (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C5orf64

SOURCE GeneReport for Unigene cluster for C5orf64 Gene:

Hs.683866

Evidence on tissue expression from TISSUES for C5orf64 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C5orf64: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf64 Gene

Orthologs for C5orf64 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf64 30
  • 97.74 (n)
C5orf64 31
  • 95 (a)
OneToOne
Species where no ortholog for C5orf64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf64 Gene

ENSEMBL:
Gene Tree for C5orf64 (if available)
TreeFam:
Gene Tree for C5orf64 (if available)

Paralogs for C5orf64 Gene

No data available for Paralogs for C5orf64 Gene

Variants for C5orf64 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C5orf64 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs16893687 - p.Ala57Thr
rs436696 - p.Arg101Trp

Additional dbSNP identifiers (rs#s) for C5orf64 Gene

Structural Variations from Database of Genomic Variants (DGV) for C5orf64 Gene

Variant ID Type Subtype PubMed ID
esv2671982 CNV deletion 23128226
esv2730246 CNV deletion 23290073
esv2730247 CNV deletion 23290073
esv3605219 CNV loss 21293372
esv3605221 CNV gain 21293372
esv3894197 CNV loss 25118596

Variation tolerance for C5orf64 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.68; 95.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf64 Gene

Disorders for C5orf64 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C5orf64 Gene - From: DISEASES

Disorder Aliases PubMed IDs
waardenburg syndrome, type 1
  • ws1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C5orf64

genes like me logo Genes that share disorders with C5orf64: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C5orf64 Gene

Publications for C5orf64 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 54
  5. Genome-wide association study of Alzheimer's disease. (PMID: 22832961) Kamboh MI … Barmada MM (Translational psychiatry 2012) 3 54

Products for C5orf64 Gene

Sources for C5orf64 Gene