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Aliases for C5orf63 Gene

Aliases for C5orf63 Gene

  • Chromosome 5 Open Reading Frame 63 2 3 5
  • Glutaredoxin-Like Protein YDR286C Homolog 3
  • Glutaredoxin-Like Protein C5orf63 3
  • YDR286C 3

External Ids for C5orf63 Gene

Previous GeneCards Identifiers for C5orf63 Gene

  • GC05M126379

Summaries for C5orf63 Gene

GeneCards Summary for C5orf63 Gene

C5orf63 (Chromosome 5 Open Reading Frame 63) is a Protein Coding gene.

Additional gene information for C5orf63 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf63 Gene

Genomics for C5orf63 Gene

GeneHancer (GH) Regulatory Elements for C5orf63 Gene

Promoters and enhancers for C5orf63 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J127072 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 658.7 +0.2 177 1.4 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 SLC30A9 GLIS2 MARCH3 C5orf63 ENSG00000279446 PRRC1
GH05J127028 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.2 +43.2 43231 3.4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 MARCH3 LOC105379163 PIR49999 GC05P127033 CCDC192 C5orf63 GC05M127022
GH05J127040 Enhancer 1 Ensembl ENCODE 7 +32.1 32067 2.4 KLF17 MZF1 FEZF1 RAD21 ZNF2 ZNF335 EGR1 ZNF366 KLF7 EGR2 C5orf63 MARCH3
GH05J126970 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.4 +101.6 101633 3.8 PKNOX1 ATF1 SMAD1 ARNT NCOA2 TCF12 ZNF766 GATA2 ZNF207 ZFP91 MARCH3 PRRC1 C5orf63 GC05M127022 GC05M126868
GH05J127076 Enhancer 0.6 ENCODE 8.1 -3.4 -3402 1.9 SMARCE1 NANOG JUN CEBPG RARA NR2F2 FOSL1 SMARCA4 CEBPA MARCH3 C5orf63 ENSG00000279446 MRPS5P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5orf63 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C5orf63 Gene

Genomic Locations for C5orf63 Gene
37,874 bases
Minus strand
30,935 bases
Minus strand

Genomic View for C5orf63 Gene

Genes around C5orf63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf63 Gene

Proteins for C5orf63 Gene

  • Protein details for C5orf63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutaredoxin-like protein C5orf63
    Protein Accession:
    Secondary Accessions:
    • G3V557

    Protein attributes for C5orf63 Gene

    138 amino acids
    Molecular mass:
    15764 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf63 Gene


neXtProt entry for C5orf63 Gene

Post-translational modifications for C5orf63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C5orf63 Gene

Domains & Families for C5orf63 Gene

Gene Families for C5orf63 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf63 Gene

Suggested Antigen Peptide Sequences for C5orf63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutaredoxin family. YDR286C subfamily.
  • Belongs to the glutaredoxin family. YDR286C subfamily.
genes like me logo Genes that share domains with C5orf63: view

Function for C5orf63 Gene

genes like me logo Genes that share phenotypes with C5orf63: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf63 Gene

Localization for C5orf63 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf63 gene
Compartment Confidence
mitochondrion 4
extracellular 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf63 Gene

Pathways & Interactions for C5orf63 Gene

SuperPathways for C5orf63 Gene

No Data Available

Interacting Proteins for C5orf63 Gene

Gene Ontology (GO) - Biological Process for C5orf63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with C5orf63: view

No data available for Pathways by source and SIGNOR curated interactions for C5orf63 Gene

Drugs & Compounds for C5orf63 Gene

No Compound Related Data Available

Transcripts for C5orf63 Gene

mRNA/cDNA for C5orf63 Gene

Unigene Clusters for C5orf63 Gene

Chromosome 5 open reading frame 63:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf63 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - -
SP3: - - - -
SP4: -

Relevant External Links for C5orf63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf63 Gene

Protein differential expression in normal tissues from HIPED for C5orf63 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf63 Gene

Protein tissue co-expression partners for C5orf63 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C5orf63 Gene:


SOURCE GeneReport for Unigene cluster for C5orf63 Gene:


Evidence on tissue expression from TISSUES for C5orf63 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with C5orf63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf63 Gene

Orthologs for C5orf63 Gene

This gene was present in the common ancestor of animals.

Orthologs for C5orf63 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5H5orf63 33
  • 100 (n)
(Canis familiaris)
Mammalia C11H5orf63 33
  • 89.77 (n)
C5orf63 34
  • 46 (a)
(Bos Taurus)
Mammalia C7H5orf63 33
  • 89.57 (n)
C5orf63 34
  • 48 (a)
(Rattus norvegicus)
Mammalia LOC100174910 33
  • 89.39 (n)
(Mus musculus)
Mammalia C330018D20Rik 16 34 33
  • 88.18 (n)
(Monodelphis domestica)
Mammalia C5orf63 34
  • 35 (a)
(Gallus gallus)
Aves CZH5ORF63 33
  • 66.67 (n)
C5orf63 34
  • 30 (a)
(Anolis carolinensis)
Reptilia C5orf63 34
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733920 33
  • 63.43 (n)
(Danio rerio)
Actinopterygii im:7154516 33
  • 70.88 (n)
C10H5orf63 34
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9147 34
  • 6 (a)
Species where no ortholog for C5orf63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf63 Gene

Gene Tree for C5orf63 (if available)
Gene Tree for C5orf63 (if available)

Paralogs for C5orf63 Gene Pseudogenes for C5orf63 Gene

genes like me logo Genes that share paralogs with C5orf63: view

No data available for Paralogs for C5orf63 Gene

Variants for C5orf63 Gene

Sequence variations from dbSNP and Humsavar for C5orf63 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000032357 -- 127,069,240(-) T/A intron_variant
rs1000032902 -- 127,065,422(-) G/A intron_variant
rs1000088402 -- 127,072,639(-) T/C intron_variant
rs1000178416 -- 127,058,552(-) C/A intron_variant
rs1000244463 -- 127,065,838(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf63 Gene

Variant ID Type Subtype PubMed ID
nsv1033607 CNV gain 25217958

Variation tolerance for C5orf63 Gene

Gene Damage Index Score: 1.25; 25.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf63 Gene

Disorders for C5orf63 Gene

Additional Disease Information for C5orf63

No disorders were found for C5orf63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf63 Gene

Publications for C5orf63 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 58

Products for C5orf63 Gene

Sources for C5orf63 Gene

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