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Aliases for C5orf56 Gene

Aliases for C5orf56 Gene

  • Chromosome 5 Open Reading Frame 56 2 3 5

External Ids for C5orf56 Gene

Previous GeneCards Identifiers for C5orf56 Gene

  • GC05P131775
  • GC05P126938

Summaries for C5orf56 Gene

GeneCards Summary for C5orf56 Gene

C5orf56 (Chromosome 5 Open Reading Frame 56) is a Protein Coding gene.

Additional gene information for C5orf56 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf56 Gene

Genomics for C5orf56 Gene

GeneHancer (GH) Regulatory Elements for C5orf56 Gene

Promoters and enhancers for C5orf56 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I132770 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.8 +363.9 363867 7.9 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF143 ZNF263 SP3 SEPT8 GC05M132776 GC05M132777 IL4 ENSG00000202533 LOC105379175 CCNI2 KIF3A SOWAHA AFF4
GH05I133048 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 +640.5 640465 5.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 HSPA4 GC05M133050 GC05M133049 ENSG00000279691 AFF4 IL4 ENSG00000202533 LOC105379175 RAD50 ENSG00000224431
GH05I132555 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +147.0 146971 3.3 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC RAD50 IL5 AFF4 LOC105379175 IL4 ENSG00000202533 ENSG00000224431 ZCCHC10 C5orf56 FNIP1
GH05I132452 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 +56.6 56608 29.7 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B FEZF1 DMAP1 IRF4 YY1 ENSG00000202533 GC05P132469 AFF4 RAD50 IRF1 SLC22A5 IL4 LOC102723741 MIR3936HG ENSG00000224431
GH05I132433 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +27.0 27001 7.3 FOXA2 IRF4 RAD21 RARA YY1 EGR1 SCRT2 ETV6 FOS IKZF2 LOC105379175 SLC22A5 IRF1 C5orf56 ENSG00000202533 MIR3936HG KIF3A SLC22A4 LOC102723741 ENSG00000283782
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C5orf56 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C5orf56 gene promoter:

Genomic Locations for C5orf56 Gene

Genomic Locations for C5orf56 Gene
chr5:132,410,636-132,488,702
(GRCh38/hg38)
Size:
78,067 bases
Orientation:
Plus strand
chr5:131,746,328-131,822,549
(GRCh37/hg19)

Genomic View for C5orf56 Gene

Genes around C5orf56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf56 Gene

Proteins for C5orf56 Gene

  • Protein details for C5orf56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8D9-CE056_HUMAN
    Recommended name:
    Uncharacterized protein C5orf56
    Protein Accession:
    Q8N8D9
    Secondary Accessions:
    • A1L3V9
    • A6NKA0

    Protein attributes for C5orf56 Gene

    Size:
    126 amino acids
    Molecular mass:
    14652 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf56 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C5orf56 Gene

Post-translational modifications for C5orf56 Gene

No Post-translational modifications

Other Protein References for C5orf56 Gene

No data available for DME Specific Peptides for C5orf56 Gene

Domains & Families for C5orf56 Gene

Gene Families for C5orf56 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf56 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf56: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf56 Gene

Function for C5orf56 Gene

Phenotypes From GWAS Catalog for C5orf56 Gene

Phenotypes for C5orf56 Gene

GenomeRNAi human phenotypes for C5orf56:
genes like me logo Genes that share phenotypes with C5orf56: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf56 Gene

Localization for C5orf56 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf56 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf56 Gene

Pathways & Interactions for C5orf56 Gene

SuperPathways for C5orf56 Gene

No Data Available

Interacting Proteins for C5orf56 Gene

Gene Ontology (GO) - Biological Process for C5orf56 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf56 Gene

Drugs & Compounds for C5orf56 Gene

No Compound Related Data Available

Transcripts for C5orf56 Gene

Unigene Clusters for C5orf56 Gene

Chromosome 5 open reading frame 56:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf56 Gene

No ASD Table

Relevant External Links for C5orf56 Gene

GeneLoc Exon Structure for
C5orf56
ECgene alternative splicing isoforms for
C5orf56

Expression for C5orf56 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf56 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf56 Gene:

C5orf56

SOURCE GeneReport for Unigene cluster for C5orf56 Gene:

Hs.658288
genes like me logo Genes that share expression patterns with C5orf56: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf56 Gene

Orthologs for C5orf56 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5orf56 34
  • 99 (a)
OneToOne
Species where no ortholog for C5orf56 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf56 Gene

ENSEMBL:
Gene Tree for C5orf56 (if available)
TreeFam:
Gene Tree for C5orf56 (if available)

Paralogs for C5orf56 Gene

No data available for Paralogs for C5orf56 Gene

Variants for C5orf56 Gene

Sequence variations from dbSNP and Humsavar for C5orf56 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000009581 -- 132,436,559(+) A/G intron_variant
rs1000045924 -- 132,439,765(+) C/A intron_variant
rs1000047544 -- 132,449,949(+) G/T intron_variant
rs1000192681 -- 132,475,409(+) C/T intron_variant
rs1000196491 -- 132,458,526(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf56 Gene

Variant ID Type Subtype PubMed ID
nsv950391 CNV duplication 24416366
nsv599713 CNV gain 21841781
nsv5002 CNV insertion 18451855
nsv471048 CNV gain 18288195
nsv462452 CNV gain 19166990
nsv1161299 CNV deletion 26073780

Variation tolerance for C5orf56 Gene

Gene Damage Index Score: 0.88; 18.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf56 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf56

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf56 Gene

Disorders for C5orf56 Gene

Additional Disease Information for C5orf56

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C5orf56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf56 Gene

Publications for C5orf56 Gene

  1. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 44 58
  2. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PMID: 19760754) Törkvist L … Pettersson S (Inflammatory bowel diseases 2010) 3 44 58
  3. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PMID: 20886065) Cleynen I … Vermeire S (PloS one 2010) 3 44 58
  4. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. (PMID: 20570966) McGovern DP … International IBD Genetics Consortium (Human molecular genetics 2010) 3 44 58
  5. Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. (PMID: 20031576) Dehghan A … Folsom AR (Circulation. Cardiovascular genetics 2009) 3 44 58

Products for C5orf56 Gene

Sources for C5orf56 Gene

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