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Aliases for C5orf51 Gene

Aliases for C5orf51 Gene

  • Chromosome 5 Open Reading Frame 51 2 3 5

External Ids for C5orf51 Gene

Previous GeneCards Identifiers for C5orf51 Gene

  • GC05P041940
  • GC05P041857
  • GC05P041905
  • GC05P041906
  • GC05P041907
  • GC05P041908
  • GC05P041909
  • GC05P041910
  • GC05P041911
  • GC05P041913
  • GC05P041914
  • GC05P041915
  • GC05P041916
  • GC05P041917
  • GC05P041920
  • GC05P041922

Summaries for C5orf51 Gene

GeneCards Summary for C5orf51 Gene

C5orf51 (Chromosome 5 Open Reading Frame 51) is a Protein Coding gene.

Additional gene information for C5orf51 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf51 Gene

Genomics for C5orf51 Gene

GeneHancer (GH) Regulatory Elements for C5orf51 Gene

Promoters and enhancers for C5orf51 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I041903 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.5 +0.3 295 2.5 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC C5orf51 FBXO4 SERBP1P6 OXCT1-AS1 CCDC152 GC05P041926 PIR36450
GH05I041869 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 -33.9 -33879 2.6 HDGF ARNT SIN3A ZNF2 YY1 POLR2B ZNF213 ZNF207 ZNF143 SP3 OXCT1 LOC102723752 OXCT1-AS1 FBXO4 C5orf51
GH05I042422 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 9.8 +519.9 519937 2.6 PKNOX1 ATF1 ZFP64 SIN3A GLI4 ZNF2 YY1 ZNF121 GLIS2 KLF7 GHR ZNF131 OXCT1-AS1 C5orf51 ENSG00000250860
GH05I041871 Enhancer 0.9 Ensembl ENCODE 11.5 -32.3 -32315 0.4 ZBTB21 INSM2 MZF1 ZNF302 ZNF366 PRDM10 KLF8 ZBTB20 ZNF189 ZEB2 OXCT1 OXCT1-AS1 C5orf51 FBXO4 LOC102723752 RPS2P22
GH05I041856 Enhancer 0.9 FANTOM5 ENCODE 10.7 -47.3 -47344 0.2 HDGF CTCF KLF1 RB1 RAD21 RFX5 CC2D1A ARID2 SCRT2 SMC3 FBXO4 C5orf51 OXCT1 LOC102723752 GC05M041733
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C5orf51 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C5orf51 gene promoter:

Genomic Locations for C5orf51 Gene

Genomic Locations for C5orf51 Gene
chr5:41,904,188-41,921,636
(GRCh38/hg38)
Size:
17,449 bases
Orientation:
Plus strand
chr5:41,904,290-41,921,738
(GRCh37/hg19)

Genomic View for C5orf51 Gene

Genes around C5orf51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf51 Gene

Proteins for C5orf51 Gene

  • Protein details for C5orf51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDU8-CE051_HUMAN
    Recommended name:
    UPF0600 protein C5orf51
    Protein Accession:
    A6NDU8
    Secondary Accessions:
    • A2RRM9

    Protein attributes for C5orf51 Gene

    Size:
    294 amino acids
    Molecular mass:
    33620 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31722.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

neXtProt entry for C5orf51 Gene

Post-translational modifications for C5orf51 Gene

  • Ubiquitination at posLast=9797
  • Modification sites at PhosphoSitePlus

Other Protein References for C5orf51 Gene

No data available for DME Specific Peptides for C5orf51 Gene

Domains & Families for C5orf51 Gene

Gene Families for C5orf51 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf51 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C5orf51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NDU8

UniProtKB/Swiss-Prot:

CE051_HUMAN :
  • Belongs to the UPF0600 family.
Family:
  • Belongs to the UPF0600 family.
genes like me logo Genes that share domains with C5orf51: view

Function for C5orf51 Gene

genes like me logo Genes that share phenotypes with C5orf51: view

miRNA for C5orf51 Gene

miRTarBase miRNAs that target C5orf51

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf51 Gene

Localization for C5orf51 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf51 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C5orf51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C5orf51: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C5orf51 Gene

Pathways & Interactions for C5orf51 Gene

SuperPathways for C5orf51 Gene

No Data Available

Interacting Proteins for C5orf51 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371061%0d%0a9606.ENSP00000264108%0d%0a
Selected Interacting proteins: ENSP00000371061 A6NDU8-CE051_HUMAN for C5orf51 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C5orf51 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf51 Gene

Drugs & Compounds for C5orf51 Gene

No Compound Related Data Available

Transcripts for C5orf51 Gene

mRNA/cDNA for C5orf51 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5orf51 Gene

Chromosome 5 open reading frame 51:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf51 Gene

No ASD Table

Relevant External Links for C5orf51 Gene

GeneLoc Exon Structure for
C5orf51
ECgene alternative splicing isoforms for
C5orf51

Expression for C5orf51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf51 Gene

Protein differential expression in normal tissues from HIPED for C5orf51 Gene

This gene is overexpressed in Bone (45.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5orf51 Gene



Protein tissue co-expression partners for C5orf51 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C5orf51 Gene:

C5orf51

SOURCE GeneReport for Unigene cluster for C5orf51 Gene:

Hs.29899
genes like me logo Genes that share expression patterns with C5orf51: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf51 Gene

Orthologs for C5orf51 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5orf51 34
  • 100 (a)
OneToOne
C5H5orf51 33
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia C5orf51 34
  • 93 (a)
OneToOne
C4H5orf51 33
  • 91.92 (n)
cow
(Bos Taurus)
Mammalia C20H5orf51 33
  • 90.33 (n)
C5orf51 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AW549877 33 16 34
  • 86.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf51 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5orf51 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH5ORF51 33
  • 64.91 (n)
lizard
(Anolis carolinensis)
Reptilia C5orf51 34
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-46a10.3 33
  • 55.96 (n)
C8H5orf51 34
  • 46 (a)
OneToOne
Species where no ortholog for C5orf51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf51 Gene

ENSEMBL:
Gene Tree for C5orf51 (if available)
TreeFam:
Gene Tree for C5orf51 (if available)

Paralogs for C5orf51 Gene

No data available for Paralogs for C5orf51 Gene

Variants for C5orf51 Gene

Sequence variations from dbSNP and Humsavar for C5orf51 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000013583 -- 41,914,724(+) C/T intron_variant
rs1000562769 -- 41,919,651(+) G/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000673912 -- 41,917,620(+) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000680739 -- 41,917,894(+) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000733520 -- 41,910,564(+) T/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf51 Gene

Variant ID Type Subtype PubMed ID
dgv1096e214 CNV gain 21293372
esv2762518 CNV loss 21179565
esv3604851 CNV gain 21293372
nsv1112872 CNV deletion 24896259
nsv327668 CNV deletion 16902084
nsv830272 CNV gain 17160897
nsv830273 CNV gain 17160897

Variation tolerance for C5orf51 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf51 Gene

Disorders for C5orf51 Gene

Additional Disease Information for C5orf51

No disorders were found for C5orf51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf51 Gene

Publications for C5orf51 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 58
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for C5orf51 Gene

Sources for C5orf51 Gene

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