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Aliases for C5orf34 Gene

Aliases for C5orf34 Gene

  • Chromosome 5 Open Reading Frame 34 2 3 5
  • Uncharacterized Protein C5orf34 3

External Ids for C5orf34 Gene

Previous GeneCards Identifiers for C5orf34 Gene

  • GC05M043524
  • GC05M043525
  • GC05M043487
  • GC05M043437
  • GC05M043488
  • GC05M043490
  • GC05M043491
  • GC05M043492
  • GC05M043493
  • GC05M043494
  • GC05M043511
  • GC05M043513
  • GC05M043515

Summaries for C5orf34 Gene

GeneCards Summary for C5orf34 Gene

C5orf34 (Chromosome 5 Open Reading Frame 34) is a Protein Coding gene.

Additional gene information for C5orf34 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf34 Gene

Genomics for C5orf34 Gene

GeneHancer (GH) Regulatory Elements for C5orf34 Gene

Promoters and enhancers for C5orf34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J043513 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 445 3.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ENSG00000248240 C5orf34 ZNF131 RPL29P12 EEF1A1P19 ENSG00000249492 NNT LOC648987 ANXA2R ENSG00000272382
GH05J043482 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.1 +30.2 30164 5.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF585B GLIS1 NBN TMEM267 ENSG00000249492 ZNF131 EEF1A1P19 RPL29P12 C5orf34 NNT CCL28 HMGCS1 ENSG00000248240
GH05J043554 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.9 -41.2 -41203 3.2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 REST SMARCB1 PAIP1 NNT C5orf34 ENSG00000249492 ENSG00000248240 EEF1A1P19 NNT-AS1 RPL29P12 FGF10-AS1 LOC153684
GH05J043191 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.4 +322.0 322042 2.8 CLOCK ARID4B SIN3A ZNF2 ZBTB7B FOS KLF13 SP3 NFYC REST NIM1K RPL29P12 EEF1A1P19 ZNF131 TMEM267 ENSG00000249492 C5orf34 LOC153684 SERBP1P6 ENSG00000272382
GH05J042807 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 10.6 +704.4 704381 7.1 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 POLR2B PAF1 SP3 MXD4 SELENOP ZNF131 CCDC152 FBXO4 PPIAP77 C5orf34 ENSG00000249492 GHR LOC648987 ENSG00000272234
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5orf34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C5orf34 gene promoter:
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • Pbx1a
  • RSRFC4
  • CUTL1

Genomic Locations for C5orf34 Gene

Genomic Locations for C5orf34 Gene
chr5:43,486,701-43,515,171
(GRCh38/hg38)
Size:
28,471 bases
Orientation:
Minus strand
chr5:43,486,803-43,515,273
(GRCh37/hg19)
Size:
28,471 bases
Orientation:
Minus strand

Genomic View for C5orf34 Gene

Genes around C5orf34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf34 Gene

Proteins for C5orf34 Gene

  • Protein details for C5orf34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MH7-CE034_HUMAN
    Recommended name:
    Uncharacterized protein C5orf34
    Protein Accession:
    Q96MH7

    Protein attributes for C5orf34 Gene

    Size:
    638 amino acids
    Molecular mass:
    72898 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf34 Gene

Post-translational modifications for C5orf34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf34 Gene

No data available for DME Specific Peptides for C5orf34 Gene

Domains & Families for C5orf34 Gene

Gene Families for C5orf34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf34 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf34: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf34 Gene

Function for C5orf34 Gene

Phenotypes From GWAS Catalog for C5orf34 Gene

genes like me logo Genes that share phenotypes with C5orf34: view

Animal Model Products

miRNA for C5orf34 Gene

miRTarBase miRNAs that target C5orf34

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf34 Gene

Localization for C5orf34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf34 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C5orf34 Gene

Pathways & Interactions for C5orf34 Gene

SuperPathways for C5orf34 Gene

No Data Available

Interacting Proteins for C5orf34 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303490%0d%0a9606.ENSP00000357362%0d%0a
Selected Interacting proteins: ENSP00000303490 Q96MH7-CE034_HUMAN for C5orf34 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C5orf34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf34 Gene

Drugs & Compounds for C5orf34 Gene

No Compound Related Data Available

Transcripts for C5orf34 Gene

mRNA/cDNA for C5orf34 Gene

Unigene Clusters for C5orf34 Gene

Chromosome 5 open reading frame 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf34 Gene

No ASD Table

Relevant External Links for C5orf34 Gene

GeneLoc Exon Structure for
C5orf34
ECgene alternative splicing isoforms for
C5orf34

Expression for C5orf34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C5orf34 Gene

This gene is overexpressed in Ovary (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5orf34 Gene



Protein tissue co-expression partners for C5orf34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C5orf34 Gene:

C5orf34

SOURCE GeneReport for Unigene cluster for C5orf34 Gene:

Hs.661641
genes like me logo Genes that share expression patterns with C5orf34: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf34 Gene

Orthologs for C5orf34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf34 33
  • 99.27 (n)
C5orf34 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H5orf34 33
  • 88.17 (n)
C5orf34 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C20H5orf34 34 33
  • 86.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 4833420G17Rik 16 34 33
  • 80.26 (n)
rat
(Rattus norvegicus)
Mammalia RGD1306227 33
  • 79.21 (n)
oppossum
(Monodelphis domestica)
Mammalia C5orf34 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf34 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH5ORF34 33
  • 59.93 (n)
C5orf34 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5orf34 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:153352 33
  • 48.82 (n)
C5H5orf34 34
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToOne
Species where no ortholog for C5orf34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf34 Gene

ENSEMBL:
Gene Tree for C5orf34 (if available)
TreeFam:
Gene Tree for C5orf34 (if available)

Paralogs for C5orf34 Gene

No data available for Paralogs for C5orf34 Gene

Variants for C5orf34 Gene

Sequence variations from dbSNP and Humsavar for C5orf34 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_035618 A breast cancer sample p.Ser266Arg
rs1000022642 -- 43,494,578(-) T/C coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000186702 -- 43,499,795(-) C/A intron_variant
rs1000197387 -- 43,492,425(-) C/A intron_variant
rs1000214662 -- 43,498,880(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf34 Gene

Variant ID Type Subtype PubMed ID
esv3604904 CNV gain 21293372
nsv830275 CNV gain 17160897
nsv964848 CNV duplication 23825009

Variation tolerance for C5orf34 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf34 Gene

Disorders for C5orf34 Gene

Additional Disease Information for C5orf34

No disorders were found for C5orf34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf34 Gene

Publications for C5orf34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for C5orf34 Gene

Sources for C5orf34 Gene

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