Aliases for C5orf34 Gene

Aliases for C5orf34 Gene

  • Chromosome 5 Open Reading Frame 34 2 3 5
  • Uncharacterized Protein C5orf34 3 4
  • FLJ32363 2
  • C5orf34 5

External Ids for C5orf34 Gene

Previous GeneCards Identifiers for C5orf34 Gene

  • GC05M043524
  • GC05M043525
  • GC05M043487
  • GC05M043437
  • GC05M043488
  • GC05M043490
  • GC05M043491
  • GC05M043521
  • GC05M043528
  • GC05M043534
  • GC05M043549
  • GC05M043492
  • GC05M043493
  • GC05M043494
  • GC05M043511
  • GC05M043513
  • GC05M043515
  • GC05M043517
  • GC05M043519
  • GC05M043566
  • GC05M043629

Summaries for C5orf34 Gene

GeneCards Summary for C5orf34 Gene

C5orf34 (Chromosome 5 Open Reading Frame 34) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C5orf34 Gene

Genomics for C5orf34 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C5orf34 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5orf34 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C5orf34

Top Transcription factor binding sites by QIAGEN in the C5orf34 gene promoter:
  • CUTL1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pbx1a
  • RSRFC4

Genomic Locations for C5orf34 Gene

Latest Assembly
chr5:43,486,699-43,515,433
(GRCh38/hg38)
Size:
28,735 bases
Orientation:
Minus strand

Previous Assembly
chr5:43,486,811-43,515,250
(GRCh37/hg19 by Entrez Gene)
Size:
28,440 bases
Orientation:
Minus strand

chr5:43,486,803-43,515,247
(GRCh37/hg19 by Ensembl)
Size:
28,445 bases
Orientation:
Minus strand

Genomic View for C5orf34 Gene

Genes around C5orf34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf34 Gene

Proteins for C5orf34 Gene

  • Protein details for C5orf34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MH7-CE034_HUMAN
    Recommended name:
    Uncharacterized protein C5orf34
    Protein Accession:
    Q96MH7

    Protein attributes for C5orf34 Gene

    Size:
    638 amino acids
    Molecular mass:
    72898 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf34 Gene

Post-translational modifications for C5orf34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf34 Gene

No data available for DME Specific Peptides for C5orf34 Gene

Domains & Families for C5orf34 Gene

Gene Families for C5orf34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf34 Gene

InterPro:
genes like me logo Genes that share domains with C5orf34: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C5orf34 Gene

Function for C5orf34 Gene

Phenotypes From GWAS Catalog for C5orf34 Gene

genes like me logo Genes that share phenotypes with C5orf34: view

miRNA for C5orf34 Gene

miRTarBase miRNAs that target C5orf34

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf34 Gene

Localization for C5orf34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf34 gene
Compartment Confidence
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C5orf34 Gene

Pathways & Interactions for C5orf34 Gene

PathCards logo

SuperPathways for C5orf34 Gene

No Data Available

Interacting Proteins for C5orf34 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000303490 Q96MH7-CE034_HUMAN for C5orf34 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C5orf34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf34 Gene

Drugs & Compounds for C5orf34 Gene

No Compound Related Data Available

Transcripts for C5orf34 Gene

mRNA/cDNA for C5orf34 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf34

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf34 Gene

No ASD Table

Relevant External Links for C5orf34 Gene

GeneLoc Exon Structure for
C5orf34

Expression for C5orf34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C5orf34 Gene

This gene is overexpressed in Ovary (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5orf34 Gene



Protein tissue co-expression partners for C5orf34 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C5orf34

SOURCE GeneReport for Unigene cluster for C5orf34 Gene:

Hs.661641
genes like me logo Genes that share expression patterns with C5orf34: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf34 Gene

Orthologs for C5orf34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf34 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C5H5orf34 29
  • 99.27 (n)
C5orf34 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C4H5orf34 29
  • 88.17 (n)
C5orf34 30
  • 84 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C20H5orf34 29 30
  • 86.88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia 4833420G17Rik 29 16 30
  • 80.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1306227 29
  • 79.21 (n)
Oppossum
(Monodelphis domestica)
Mammalia C5orf34 30
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C5orf34 30
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CZH5ORF34 29
  • 59.93 (n)
C5orf34 30
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C5orf34 30
  • 46 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii zgc:153352 29
  • 48.82 (n)
C5H5orf34 30
  • 34 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 24 (a)
OneToOne
Species where no ortholog for C5orf34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C5orf34 Gene

ENSEMBL:
Gene Tree for C5orf34 (if available)
TreeFam:
Gene Tree for C5orf34 (if available)
Alliance of Genome Resources:
Additional Orthologs for C5orf34

Paralogs for C5orf34 Gene

No data available for Paralogs for C5orf34 Gene

Variants for C5orf34 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C5orf34 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
VAR_035618 A breast cancer sample p.Ser266Arg
rs6872851 -- p.Thr32Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C5orf34 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C5orf34 Gene

Variant ID Type Subtype PubMed ID
esv3604904 CNV gain 21293372
nsv830275 CNV gain 17160897
nsv964848 CNV duplication 23825009

Variation tolerance for C5orf34 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf34
Leiden Open Variation Database (LOVD)
C5orf34

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf34 Gene

Disorders for C5orf34 Gene

Additional Disease Information for C5orf34

No disorders were found for C5orf34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf34 Gene

Publications for C5orf34 Gene

  1. Up-regulation of C5orf34 promotes lung adenocarcinoma migration and is correlated with worse prognosis. (PMID: 30771479) He D … Gao S (Gene 2019) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3

Products for C5orf34 Gene

Sources for C5orf34 Gene