Aliases for C5orf24 Gene

Aliases for C5orf24 Gene

  • Chromosome 5 Open Reading Frame 24 2 3 5
  • UPF0461 Protein C5orf24 3 4
  • FLJ37562 2
  • C5orf24 5

External Ids for C5orf24 Gene

Previous GeneCards Identifiers for C5orf24 Gene

  • GC05P134210
  • GC05P129367
  • GC05P134181

Summaries for C5orf24 Gene

GeneCards Summary for C5orf24 Gene

C5orf24 (Chromosome 5 Open Reading Frame 24) is a Protein Coding gene.

Additional gene information for C5orf24 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C5orf24 Gene

Genomics for C5orf24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C5orf24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5orf24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C5orf24

Top Transcription factor binding sites by QIAGEN in the C5orf24 gene promoter:
  • E47
  • Evi-1
  • Hand1
  • Nkx2-5
  • p53

Genomic Locations for C5orf24 Gene

Genomic Locations for C5orf24 Gene
26,133 bases
Plus strand
14,058 bases
Plus strand

Genomic View for C5orf24 Gene

Genes around C5orf24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf24 Gene

Proteins for C5orf24 Gene

  • Protein details for C5orf24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0461 protein C5orf24
    Protein Accession:
    Secondary Accessions:
    • D3DQA7
    • Q86Y53
    • Q8N1T9

    Protein attributes for C5orf24 Gene

    188 amino acids
    Molecular mass:
    20132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf24 Gene


neXtProt entry for C5orf24 Gene

Post-translational modifications for C5orf24 Gene

  • Ubiquitination at Lys41 and Lys146
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C5orf24 Gene

Domains & Families for C5orf24 Gene

Gene Families for C5orf24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf24 Gene


Suggested Antigen Peptide Sequences for C5orf24 Gene

GenScript: Design optimal peptide antigens:
  • UPF0461 protein C5orf24 (CE024_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0461 family.
  • Belongs to the UPF0461 family.
genes like me logo Genes that share domains with C5orf24: view

Function for C5orf24 Gene

Phenotypes From GWAS Catalog for C5orf24 Gene

Gene Ontology (GO) - Molecular Function for C5orf24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C5orf24: view
genes like me logo Genes that share phenotypes with C5orf24: view

Animal Model Products

CRISPR Products

miRNA for C5orf24 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf24

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf24 Gene

Localization for C5orf24 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf24 gene
Compartment Confidence
nucleus 3
endoplasmic reticulum 1
cytosol 1
lysosome 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf24 Gene

Pathways & Interactions for C5orf24 Gene

PathCards logo

SuperPathways for C5orf24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C5orf24 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf24 Gene

Drugs & Compounds for C5orf24 Gene

No Compound Related Data Available

Transcripts for C5orf24 Gene

mRNA/cDNA for C5orf24 Gene

10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf24

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf24 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b
SP1: - - - -
SP3: - - - -
SP4: - - - -
SP5: -

Relevant External Links for C5orf24 Gene

GeneLoc Exon Structure for

Expression for C5orf24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf24 Gene

Protein differential expression in normal tissues from HIPED for C5orf24 Gene

This gene is overexpressed in Serum (19.5), Fetal Brain (13.6), and Blymphocyte (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5orf24 Gene

Protein tissue co-expression partners for C5orf24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C5orf24

SOURCE GeneReport for Unigene cluster for C5orf24 Gene:


Evidence on tissue expression from TISSUES for C5orf24 Gene

  • Lung(3.9)
  • Nervous system(3.8)
  • Kidney(3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with C5orf24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf24 Gene

Orthologs for C5orf24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5orf24 31
  • 100 (a)
C5H5orf24 30
  • 99.65 (n)
(Canis familiaris)
Mammalia C5orf24 31
  • 98 (a)
C11H5orf24 30
  • 95.04 (n)
(Bos Taurus)
Mammalia C7H5orf24 30 31
  • 95.39 (n)
(Mus musculus)
Mammalia B230219D22Rik 30 17 31
  • 91.49 (n)
(Rattus norvegicus)
Mammalia RGD1566359 30
  • 89.36 (n)
(Monodelphis domestica)
Mammalia C5orf24 31
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia C5orf24 31
  • 76 (a)
(Gallus gallus)
Aves C13H5ORF24 30
  • 82.62 (n)
C5orf24 31
  • 81 (a)
(Anolis carolinensis)
Reptilia C5orf24 31
  • 79 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c5orf24 30
  • 74.91 (n)
(Danio rerio)
Actinopterygii LOC797133 30
  • 59.88 (n)
C5orf24 (1 of 2) 31
  • 46 (a)
C21H5orf24 (2 of 2) 31
  • 35 (a)
Species where no ortholog for C5orf24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C5orf24 Gene

Gene Tree for C5orf24 (if available)
Gene Tree for C5orf24 (if available)

Paralogs for C5orf24 Gene

No data available for Paralogs for C5orf24 Gene

Variants for C5orf24 Gene

Additional dbSNP identifiers (rs#s) for C5orf24 Gene

Structural Variations from Database of Genomic Variants (DGV) for C5orf24 Gene

Variant ID Type Subtype PubMed ID
dgv5810n100 CNV gain 25217958
nsv523937 CNV gain 19592680
nsv830493 CNV loss 17160897
nsv830494 CNV gain+loss 17160897

Variation tolerance for C5orf24 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C5orf24 Gene

Disorders for C5orf24 Gene

No disorders were found for C5orf24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf24 Gene

Publications for C5orf24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for C5orf24 Gene

  • Biorbyt antibodies for C5orf24

Sources for C5orf24 Gene