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Aliases for C5orf22 Gene

Aliases for C5orf22 Gene

  • Chromosome 5 Open Reading Frame 22 2 3 5

External Ids for C5orf22 Gene

Previous GeneCards Identifiers for C5orf22 Gene

  • GC05P031569
  • GC05P031498
  • GC05P031570
  • GC05P031500

Summaries for C5orf22 Gene

GeneCards Summary for C5orf22 Gene

C5orf22 (Chromosome 5 Open Reading Frame 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include beta-catenin binding.

Additional gene information for C5orf22 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf22 Gene

Genomics for C5orf22 Gene

GeneHancer (GH) Regulatory Elements for C5orf22 Gene

Promoters and enhancers for C5orf22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I031530 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.7 -0.1 -82 3.8 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B E2F8 DROSHA C5orf22 MTMR12 ENSG00000206682
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C5orf22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C5orf22 gene promoter:

Genomic Locations for C5orf22 Gene

Genomic Locations for C5orf22 Gene
22,793 bases
Plus strand

Genomic View for C5orf22 Gene

Genes around C5orf22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf22 Gene

Proteins for C5orf22 Gene

  • Protein details for C5orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0489 protein C5orf22
    Protein Accession:
    Secondary Accessions:
    • Q8ND28
    • Q8WU61
    • Q9NUR1

    Protein attributes for C5orf22 Gene

    442 amino acids
    Molecular mass:
    49967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf22 Gene


neXtProt entry for C5orf22 Gene

Post-translational modifications for C5orf22 Gene

  • Ubiquitination at posLast=118118
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C5orf22 Gene

Domains & Families for C5orf22 Gene

Gene Families for C5orf22 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf22 Gene


Suggested Antigen Peptide Sequences for C5orf22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0489 family.
  • Belongs to the UPF0489 family.
genes like me logo Genes that share domains with C5orf22: view

Function for C5orf22 Gene

Gene Ontology (GO) - Molecular Function for C5orf22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C5orf22: view
genes like me logo Genes that share phenotypes with C5orf22: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf22 Gene

Localization for C5orf22 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf22 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf22 Gene

Pathways & Interactions for C5orf22 Gene

SuperPathways for C5orf22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C5orf22 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf22 Gene

Drugs & Compounds for C5orf22 Gene

No Compound Related Data Available

Transcripts for C5orf22 Gene

Unigene Clusters for C5orf22 Gene

Chromosome 5 open reading frame 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf22 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP7: - - - - -
SP9: - - -

Relevant External Links for C5orf22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf22 Gene

Protein differential expression in normal tissues from HIPED for C5orf22 Gene

This gene is overexpressed in Lymph node (17.5), Blymphocyte (11.0), Peripheral blood mononuclear cells (8.1), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C5orf22 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf22 Gene:


SOURCE GeneReport for Unigene cluster for C5orf22 Gene:


Evidence on tissue expression from TISSUES for C5orf22 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with C5orf22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf22 Gene

Orthologs for C5orf22 Gene

This gene was present in the common ancestor of animals.

Orthologs for C5orf22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5orf22 34
  • 100 (a)
C5H5orf22 33
  • 99.47 (n)
(Canis familiaris)
Mammalia C4H5orf22 33
  • 91.03 (n)
C5orf22 34
  • 88 (a)
(Bos Taurus)
Mammalia C20H5ORF22 34
  • 86 (a)
(Rattus norvegicus)
Mammalia RGD1306502 33
  • 83.49 (n)
(Mus musculus)
Mammalia 6030458C11Rik 33 16 34
  • 81.78 (n)
(Monodelphis domestica)
Mammalia C5orf22 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia C5orf22 34
  • 61 (a)
(Gallus gallus)
Aves C5ORF22 33
  • 69.84 (n)
C5orf22 34
  • 64 (a)
(Anolis carolinensis)
Reptilia C5orf22 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c5orf22 33
  • 69.01 (n)
Str.11883 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68801 33
(Danio rerio)
Actinopterygii zgc:56556 33
  • 59.6 (n)
C2H5orf22 34
  • 56 (a)
zgc56556 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005414 33
  • 47.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta MESR6 34 33
  • 47.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for C5orf22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf22 Gene

Gene Tree for C5orf22 (if available)
Gene Tree for C5orf22 (if available)

Paralogs for C5orf22 Gene

No data available for Paralogs for C5orf22 Gene

Variants for C5orf22 Gene

Sequence variations from dbSNP and Humsavar for C5orf22 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000130906 -- 31,549,779(+) G/A intron_variant
rs1000210208 -- 31,543,126(+) C/A intron_variant
rs1000267384 -- 31,549,392(+) C/G intron_variant
rs1000448397 -- 31,551,332(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000660907 -- 31,543,477(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf22 Gene

Variant ID Type Subtype PubMed ID
esv34132 CNV loss 18971310
esv3604580 CNV gain 21293372
nsv830249 CNV gain 17160897

Variation tolerance for C5orf22 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf22 Gene

Disorders for C5orf22 Gene

Additional Disease Information for C5orf22

No disorders were found for C5orf22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf22 Gene

Publications for C5orf22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 58

Products for C5orf22 Gene

Sources for C5orf22 Gene

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