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Aliases for C5orf15 Gene

Aliases for C5orf15 Gene

  • Chromosome 5 Open Reading Frame 15 2 3 5
  • KCT2 3 4
  • Keratinocytes Associated Transmembrane Protein 2 3
  • Keratinocyte Associated Transmembrane Protein 2 2
  • Keratinocyte-Associated Transmembrane Protein 2 3
  • HTGN29 3

External Ids for C5orf15 Gene

Previous GeneCards Identifiers for C5orf15 Gene

  • GC05M133368
  • GC05M133319
  • GC05M133291
  • GC05M128476

Summaries for C5orf15 Gene

GeneCards Summary for C5orf15 Gene

C5orf15 (Chromosome 5 Open Reading Frame 15) is a Protein Coding gene.

Additional gene information for C5orf15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf15 Gene

Genomics for C5orf15 Gene

GeneHancer (GH) Regulatory Elements for C5orf15 Gene

Promoters and enhancers for C5orf15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I133967 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 550.8 -0.3 -263 3.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 C5orf15 LOC105379183 VDAC1 DDX46 ENSG00000270177 GC05P134006
GH05I133048 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +917.7 917686 5.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 HSPA4 GC05M133050 GC05M133049 ENSG00000279691 AFF4 IL4 ENSG00000202533 LOC105379175 RAD50 ENSG00000224431
GH05I134002 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.3 -35.7 -35702 4.9 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF213 ZNF143 VDAC1 GC05P134006 ENSG00000271737 DDX46 ZCCHC10 C5orf15
GH05I133976 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -9.3 -9250 2.1 SOX13 SRF FOXA2 SAP130 ZFP64 JUNB HMG20A BATF GLIS1 IKZF1 VDAC1 PPP2CA UBE2B C5orf15 GC05P134006
GH05I133994 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -26.5 -26517 2.3 FOXA2 ARID4B KLF17 RAD21 ZNF335 GLIS2 FOS SP5 CEBPB REST VDAC1 GC05P134006 C5orf15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C5orf15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C5orf15 gene promoter:

Genomic Locations for C5orf15 Gene

Genomic Locations for C5orf15 Gene
chr5:133,955,502-133,968,787
(GRCh38/hg38)
Size:
13,286 bases
Orientation:
Minus strand
chr5:133,291,198-133,304,478
(GRCh37/hg19)

Genomic View for C5orf15 Gene

Genes around C5orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf15 Gene

Proteins for C5orf15 Gene

  • Protein details for C5orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC54-KCT2_HUMAN
    Recommended name:
    Keratinocyte-associated transmembrane protein 2
    Protein Accession:
    Q8NC54
    Secondary Accessions:
    • B2RD10
    • D3DQ92
    • Q9NRG2

    Protein attributes for C5orf15 Gene

    Size:
    265 amino acids
    Molecular mass:
    29235 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf15 Gene

Post-translational modifications for C5orf15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C5orf15 Gene

Domains & Families for C5orf15 Gene

Gene Families for C5orf15 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C5orf15 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf15: view

No data available for UniProtKB/Swiss-Prot for C5orf15 Gene

Function for C5orf15 Gene

Phenotypes From GWAS Catalog for C5orf15 Gene

genes like me logo Genes that share phenotypes with C5orf15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf15 Gene

Localization for C5orf15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf15 gene
Compartment Confidence
plasma membrane 2
nucleus 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C5orf15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C5orf15: view

Pathways & Interactions for C5orf15 Gene

SuperPathways for C5orf15 Gene

No Data Available

Interacting Proteins for C5orf15 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000231512%0d%0a9606.ENSP00000328133%0d%0a9606.ENSP00000367220%0d%0a
Selected Interacting proteins: ENSP00000231512 Q8NC54-KCT2_HUMAN for C5orf15 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C5orf15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf15 Gene

Drugs & Compounds for C5orf15 Gene

No Compound Related Data Available

Transcripts for C5orf15 Gene

mRNA/cDNA for C5orf15 Gene

Unigene Clusters for C5orf15 Gene

Chromosome 5 open reading frame 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for C5orf15 Gene

GeneLoc Exon Structure for
C5orf15
ECgene alternative splicing isoforms for
C5orf15

Expression for C5orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf15 Gene

Protein differential expression in normal tissues from HIPED for C5orf15 Gene

This gene is overexpressed in Adrenal (22.3), Islet of Langerhans (19.4), Vitreous humor (11.1), and Fetal heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C5orf15 Gene



NURSA nuclear receptor signaling pathways regulating expression of C5orf15 Gene:

C5orf15

SOURCE GeneReport for Unigene cluster for C5orf15 Gene:

Hs.744034

mRNA Expression by UniProt/SwissProt for C5orf15 Gene:

Q8NC54-KCT2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for C5orf15 Gene

  • Kidney(4.4)
  • Liver(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with C5orf15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf15 Gene

Orthologs for C5orf15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf15 33
  • 99.37 (n)
C5orf15 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H5orf15 33
  • 85.35 (n)
C5orf15 34
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H5orf15 33
  • 83.59 (n)
C7H5ORF15 34
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310352 33
  • 70.24 (n)
mouse
(Mus musculus)
Mammalia 9530068E07Rik 33 16 34
  • 67.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf15 34
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5orf15 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves C13H5ORF15 33 34
  • 59.46 (n)
lizard
(Anolis carolinensis)
Reptilia C5orf15 34
  • 26 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14510 33
zebrafish
(Danio rerio)
Actinopterygii C21H5orf15 34
  • 15 (a)
OneToOne
Species where no ortholog for C5orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf15 Gene

ENSEMBL:
Gene Tree for C5orf15 (if available)
TreeFam:
Gene Tree for C5orf15 (if available)

Paralogs for C5orf15 Gene

Pseudogenes.org Pseudogenes for C5orf15 Gene

genes like me logo Genes that share paralogs with C5orf15: view

No data available for Paralogs for C5orf15 Gene

Variants for C5orf15 Gene

Sequence variations from dbSNP and Humsavar for C5orf15 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000234126 -- 133,964,819(-) A/C intron_variant
rs1000753757 -- 133,961,231(-) G/T intron_variant
rs1001084276 -- 133,966,502(-) T/A intron_variant
rs1001205621 -- 133,966,119(-) G/A intron_variant
rs1001421390 -- 133,967,814(-) A/G intron_variant

Variation tolerance for C5orf15 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C5orf15 Gene

Disorders for C5orf15 Gene

Additional Disease Information for C5orf15

No disorders were found for C5orf15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf15 Gene

Publications for C5orf15 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PMID: 12752121) Bonkobara M … Ariizumi K (The British journal of dermatology 2003) 3 4 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for C5orf15 Gene

Sources for C5orf15 Gene

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