Aliases for C5orf58 Gene

Aliases for C5orf58 Gene

  • Chromosome 5 Open Reading Frame 58 2 3 5
  • Putative Uncharacterized Protein C5orf58 3 4
  • C5orf58 5

External Ids for C5orf58 Gene

Previous GeneCards Identifiers for C5orf58 Gene

  • GC05P169592
  • GC05P164758

Summaries for C5orf58 Gene

GeneCards Summary for C5orf58 Gene

C5orf58 (Chromosome 5 Open Reading Frame 58) is a Protein Coding gene.

Additional gene information for C5orf58 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C5orf58 Gene

Genomics for C5orf58 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C5orf58 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J170232 Promoter 0.6 EPDnew 600.7 +0.5 519 0.1 SIX5 HCFC1 ZNF143 C5orf58 lnc-LCP2-4 LCP2
GH05J170229 Promoter 0.3 EPDnew 600.7 -3.3 -3329 0.1 C5orf58 RF00017-5088 FOXI1
GH05J170251 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.4 +21.7 21654 6.6 POLR2A EZH2 MNT ZBTB20 RFX1 HMBOX1 RUNX3 NFE2 ZNF316 OSR2 C5orf58 LCP2 LINC01187 KCNIP1-OT1 KCNMB1 lnc-KCNMB1-4 lnc-KCNMB1-5
GH05J170329 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.1 +100.1 100066 5.6 SP1 YBX1 LEF1 IKZF1 JUND ETV6 GABPA RELA ZIC2 ZSCAN4 LINC01366 lnc-KCNIP1-6 lnc-LCP2-7 LCP2 KCNIP1-OT1 KCNMB1 C5orf58 lnc-KCNIP1-5 KCNIP1
GH05J170273 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.5 +53.7 53707 26 SP1 CTCF TEAD4 PRDM10 ZNF512 RFX1 LEF1 BACH1 JUND LARP7 LCP2 KCNMB1 SLIT3 KCNIP1-OT1 C5orf58 lnc-C5orf58-5 LINC01366
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5orf58 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C5orf58

Genomic Locations for C5orf58 Gene

Genomic Locations for C5orf58 Gene
chr5:170,232,447-170,252,575
(GRCh38/hg38)
Size:
20,129 bases
Orientation:
Plus strand
chr5:169,659,451-169,679,579
(GRCh37/hg19)
Size:
20,129 bases
Orientation:
Plus strand

Genomic View for C5orf58 Gene

Genes around C5orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf58 Gene

Proteins for C5orf58 Gene

  • Protein details for C5orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9J3I9-CE058_HUMAN
    Recommended name:
    Putative uncharacterized protein C5orf58
    Protein Accession:
    C9J3I9

    Protein attributes for C5orf58 Gene

    Size:
    102 amino acids
    Molecular mass:
    11666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf58 Gene

Post-translational modifications for C5orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf58 Gene

No data available for DME Specific Peptides for C5orf58 Gene

Domains & Families for C5orf58 Gene

Gene Families for C5orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf58 Gene

ProtoNet:
genes like me logo Genes that share domains with C5orf58: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C5orf58 Gene

Function for C5orf58 Gene

Phenotypes From GWAS Catalog for C5orf58 Gene

genes like me logo Genes that share phenotypes with C5orf58: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf58 Gene

Localization for C5orf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf58 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 0
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C5orf58 Gene

Pathways & Interactions for C5orf58 Gene

PathCards logo

SuperPathways for C5orf58 Gene

No Data Available

Interacting Proteins for C5orf58 Gene

Gene Ontology (GO) - Biological Process for C5orf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf58 Gene

Drugs & Compounds for C5orf58 Gene

No Compound Related Data Available

Transcripts for C5orf58 Gene

mRNA/cDNA for C5orf58 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5orf58

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf58 Gene

No ASD Table

Relevant External Links for C5orf58 Gene

GeneLoc Exon Structure for
C5orf58

Expression for C5orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for C5orf58 Gene

This gene is overexpressed in Testis (x43.4).

Protein differential expression in normal tissues from HIPED for C5orf58 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf58 Gene



Protein tissue co-expression partners for C5orf58 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C5orf58

SOURCE GeneReport for Unigene cluster for C5orf58 Gene:

Hs.519749

Evidence on tissue expression from TISSUES for C5orf58 Gene

  • Lung(2.9)
  • Kidney(2.7)
  • Intestine(2.4)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with C5orf58: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf58 Gene

Orthologs for C5orf58 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf58 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C5H5orf58 30
  • 99.67 (n)
C5orf58 31
  • 99 (a)
OneToOne
Species where no ortholog for C5orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C5orf58 Gene

ENSEMBL:
Gene Tree for C5orf58 (if available)
TreeFam:
Gene Tree for C5orf58 (if available)

Paralogs for C5orf58 Gene

No data available for Paralogs for C5orf58 Gene

Variants for C5orf58 Gene

Additional dbSNP identifiers (rs#s) for C5orf58 Gene

Structural Variations from Database of Genomic Variants (DGV) for C5orf58 Gene

Variant ID Type Subtype PubMed ID
nsv1115705 CNV duplication 24896259
nsv1149960 CNV duplication 26484159
nsv830547 CNV gain+loss 17160897

Variation tolerance for C5orf58 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C5orf58 Gene

Disorders for C5orf58 Gene

No disorders were found for C5orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf58 Gene

Publications for C5orf58 Gene

  1. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for C5orf58 Gene

Sources for C5orf58 Gene