This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene ... See more...

Aliases for C5AR2 Gene

Aliases for C5AR2 Gene

  • Complement Component 5a Receptor 2 2 3 4 5
  • C5L2 2 3 4
  • C5a Anaphylatoxin Chemotactic Receptor 2 3 4
  • G Protein-Coupled Receptor 77 2 3
  • GPR77 3 4
  • C5a Anaphylatoxin Chemotactic Receptor C5L2 3
  • G Protein-Coupled Receptor C5L2 3
  • G-Protein Coupled Receptor 77 4
  • GPF77 3
  • C5AR2 5

External Ids for C5AR2 Gene

Previous HGNC Symbols for C5AR2 Gene

  • GPR77

Previous GeneCards Identifiers for C5AR2 Gene

  • GC19P047841

Summaries for C5AR2 Gene

Entrez Gene Summary for C5AR2 Gene

  • This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for C5AR2 Gene

C5AR2 (Complement Component 5a Receptor 2) is a Protein Coding gene. Diseases associated with C5AR2 include Complement Component 5 Deficiency and Complement Component 3 Deficiency. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is C5AR1.

UniProtKB/Swiss-Prot Summary for C5AR2 Gene

  • Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Gene Wiki entry for C5AR2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C5AR2 Gene

Genomics for C5AR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C5AR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047329 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 253 -0.5 -468 3.7 IKZF1 ZNF592 TBP TEAD3 NFE2 PRDM10 STAT5A CBX1 SOX5 SMARCA4 C5AR2 DHX34 C5AR1 NAPA ZC3H4 CCDC9 BICRA NOP53 piR-48389-012 lnc-C5AR1-3
GH19J047105 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 32.1 -221.3 -221317 9.2 BCLAF1 SP1 ZNF207 MYC ZNF600 NCOR1 IKZF1 SSRP1 JUND ZNF580 ZC3H4 HSALNG0126750 ENSG00000268810 BICRA C5AR2 NOP53-AS1 DHX34 INAFM1 CCDC9 PRKD2
GH19J047312 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 31.9 -18.1 -18069 1.7 NCOR1 MYC IKZF1 SSRP1 ZNF592 ZMYM3 CEBPA NFIC CHD4 YY1 DHX34 C5AR2 C5AR1 ZC3H4 BICRA CCDC9 NAPA BBC3 HSALNG0126763 HSALNG0126760
GH19J047309 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 27.1 -21.0 -21041 2.9 IKZF1 CEBPA ZNF10 NFIC CTCF REST CEBPB MAX EP300 THAP11 C5AR1 DHX34 C5AR2 ZC3H4 CCDC9 NAPA HSALNG0126763 HSALNG0126760 lnc-C5AR1-3
GH19J047351 Enhancer 1 FANTOM5 ENCODE 23.3 +20.3 20280 0.5 IKZF1 REST MNT SIN3B HCFC1 RFX5 USF2 ATF1 MAX RAD51 piR-48928 C5AR2 DHX34 ZC3H4 C5AR1 ENSG00000268810 NOP53-AS1 BICRA MEIS3 CCDC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5AR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C5AR2

Genomic Locations for C5AR2 Gene

Latest Assembly
chr19:47,331,614-47,347,329
(GRCh38/hg38)
Size:
15,716 bases
Orientation:
Plus strand

Previous Assembly
chr19:47,835,432-47,850,586
(GRCh37/hg19 by Entrez Gene)
Size:
15,155 bases
Orientation:
Plus strand

chr19:47,835,404-47,846,606
(GRCh37/hg19 by Ensembl)
Size:
11,203 bases
Orientation:
Plus strand

Genomic View for C5AR2 Gene

Genes around C5AR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5AR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5AR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5AR2 Gene

Proteins for C5AR2 Gene

  • Protein details for C5AR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P296-C5AR2_HUMAN
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 2
    Protein Accession:
    Q9P296
    Secondary Accessions:
    • B2RA09

    Protein attributes for C5AR2 Gene

    Size:
    337 amino acids
    Molecular mass:
    36080 Da
    Quaternary structure:
    • Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.

neXtProt entry for C5AR2 Gene

Post-translational modifications for C5AR2 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for C5AR2 Gene

No data available for DME Specific Peptides for C5AR2 Gene

Domains & Families for C5AR2 Gene

Gene Families for C5AR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for C5AR2 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 77 (C5ARL_HUMAN)
  • G protein-coupled receptor C5L2 (Q6NWQ8_HUMAN)
  • G protein-coupled receptor 77 (Q6NWQ9_HUMAN)
  • G protein-coupled receptor C5L2 (Q6NWR0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P296

UniProtKB/Swiss-Prot:

C5AR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C5AR2: view

Function for C5AR2 Gene

Molecular function for C5AR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Phenotypes From GWAS Catalog for C5AR2 Gene

Gene Ontology (GO) - Molecular Function for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004875 complement receptor activity IBA 21873635
GO:0004878 complement component C5a receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0005515 protein binding IPI 12540846
genes like me logo Genes that share ontologies with C5AR2: view
genes like me logo Genes that share phenotypes with C5AR2: view

Animal Models for C5AR2 Gene

MGI Knock Outs for C5AR2:

Animal Models for research

  • Taconic Biosciences Mouse Models for C5AR2

miRNA for C5AR2 Gene

miRTarBase miRNAs that target C5AR2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5AR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C5AR2 Gene

Localization for C5AR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5AR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5AR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009925 basal plasma membrane IDA 22960554
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045177 apical part of cell IDA 22496247
genes like me logo Genes that share ontologies with C5AR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C5AR2 Gene

Pathways & Interactions for C5AR2 Gene

genes like me logo Genes that share pathways with C5AR2: view

Pathways by source for C5AR2 Gene

SIGNOR curated interactions for C5AR2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IBA 21873635
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with C5AR2: view

Drugs & Compounds for C5AR2 Gene

(6) Drugs for C5AR2 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
C5a Pharma Agonist, Full agonist 0
C5a des-Arg Pharma Agonist, Full agonist 0
C5a hexapeptide analogue Pharma Agonist 0
CHIPS-(28-149) Pharma Antagonist 0
PMX 205 Pharma C5a receptor peptide antagonist, Potent C5a receptor peptide antagonist 0

(1) Additional Compounds for C5AR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for C5AR2 Gene

Compound Action Cas Number
PMX 205 C5a receptor peptide antagonist 514814-49-4
genes like me logo Genes that share compounds with C5AR2: view

Drug products for research

Transcripts for C5AR2 Gene

mRNA/cDNA for C5AR2 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C5AR2

Alternative Splicing Database (ASD) splice patterns (SP) for C5AR2 Gene

No ASD Table

Relevant External Links for C5AR2 Gene

GeneLoc Exon Structure for
C5AR2

Expression for C5AR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5AR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5AR2 Gene

This gene is overexpressed in Whole Blood (x28.7) and Spleen (x4.0).

Protein differential expression in normal tissues from HIPED for C5AR2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5AR2 Gene



Protein tissue co-expression partners for C5AR2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C5AR2

SOURCE GeneReport for Unigene cluster for C5AR2 Gene:

Hs.534412

mRNA Expression by UniProt/SwissProt for C5AR2 Gene:

Q9P296-C5AR2_HUMAN
Tissue specificity: Frontal cortex, hippocampus, hypothalamus, pons and liver.

Evidence on tissue expression from TISSUES for C5AR2 Gene

  • Nervous system(4.4)
  • Spleen(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with C5AR2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C5AR2 Gene

Orthologs for C5AR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5AR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR77 29
  • 98.52 (n)
C5AR2 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR77 29 30
  • 82.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C5AR2 29 30
  • 82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia C5ar2 29
  • 68.94 (n)
Mouse
(Mus musculus)
Mammalia C5ar2 29 16 30
  • 68.48 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C5AR2 30
  • 54 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-66d1.2 30
  • 21 (a)
ManyToMany
Species where no ortholog for C5AR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C5AR2 Gene

ENSEMBL:
Gene Tree for C5AR2 (if available)
TreeFam:
Gene Tree for C5AR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C5AR2: view image
Alliance of Genome Resources:
Additional Orthologs for C5AR2

Paralogs for C5AR2 Gene

Paralogs for C5AR2 Gene

(7) SIMAP similar genes for C5AR2 Gene using alignment to 1 proteins:

  • C5AR2_HUMAN
genes like me logo Genes that share paralogs with C5AR2: view

Variants for C5AR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C5AR2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs112290646 Benign: not provided 47,341,785(+) A/G
NM_001271749.2(C5AR2):c.986A>G (p.His329Arg)
MISSENSE
rs115216760 Benign: not provided 47,340,850(+) G/A
NM_001271749.2(C5AR2):c.51G>A (p.Ser17=)
SYNONYMOUS
rs138219631 Benign: not provided 47,341,463(+) G/A
NM_001271749.2(C5AR2):c.664G>A (p.Ala222Thr)
MISSENSE
rs142782206 Benign: not provided 47,341,694(+) C/G
NM_001271749.2(C5AR2):c.895C>G (p.Leu299Val)
MISSENSE
rs34085015 Benign: not provided 47,341,642(+) C/T
NM_001271749.2(C5AR2):c.843C>T (p.Leu281=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C5AR2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C5AR2 Gene

Variant ID Type Subtype PubMed ID
esv3430839 CNV insertion 20981092
nsv1140320 OTHER inversion 24896259

Variation tolerance for C5AR2 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5AR2 Gene

Human Gene Mutation Database (HGMD)
C5AR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5AR2
Leiden Open Variation Database (LOVD)
C5AR2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5AR2 Gene

Disorders for C5AR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for C5AR2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
complement component 5 deficiency
  • c5d
complement component 3 deficiency
  • c3 deficiency
intracranial abscess
hemolytic uremic syndrome, atypical 1
  • hemolytic uremic syndrome, atypical, susceptibility to, 1
retinitis pigmentosa
  • rp
- elite association - COSMIC cancer census association via MalaCards
Search C5AR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for C5AR2

genes like me logo Genes that share disorders with C5AR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C5AR2 Gene

Publications for C5AR2 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee DK … O'Dowd BF (Brain research. Molecular brain research 2001) 2 3 4 22
  2. The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. (PMID: 12540846) Kalant D … Monk PN (The Journal of biological chemistry 2003) 3 4 22
  3. The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). (PMID: 11773063) Cain SA … Monk PN (The Journal of biological chemistry 2002) 3 4 22
  4. A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. (PMID: 11090875) Ohno M … Takahashi TA (Molecular immunology 2000) 3 4 22
  5. Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease. (PMID: 21698200) Zheng YY … Liu F (PloS one 2011) 3 4

Products for C5AR2 Gene

Sources for C5AR2 Gene