This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is compr... See more...

Aliases for C5 Gene

Aliases for C5 Gene

  • Complement C5 2 3 4 5
  • CPAMD4 2 3 4
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4 3 4
  • Complement Component 5 2 3
  • C5a Anaphylatoxin 2 3
  • Prepro-C5 2 3
  • C5a 2 3
  • C5b 2 3
  • Anaphylatoxin C5a Analog 3
  • ECLZB 3
  • C5D 3
  • C5 5

External Ids for C5 Gene

Previous GeneCards Identifiers for C5 Gene

  • GC09M114819
  • GC09M115361
  • GC09M117168
  • GC09M119090
  • GC09M120794
  • GC09M122754
  • GC09M123714
  • GC09M093332

Summaries for C5 Gene

Entrez Gene Summary for C5 Gene

  • This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for C5 Gene

C5 (Complement C5) is a Protein Coding gene. Diseases associated with C5 include Complement Component 5 Deficiency and Eculizumab, Poor Response To. Among its related pathways are Immune response Lectin induced complement pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and endopeptidase inhibitor activity. An important paralog of this gene is C3.

UniProtKB/Swiss-Prot Summary for C5 Gene

  • Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
  • Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Gene Wiki entry for C5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C5 Gene

Genomics for C5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J121070 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 620.3 +1.2 1199 5.5 RNF2 ARHGAP35 CEBPG CREB1 GATAD2A HNRNPL YBX1 PRDM10 ZNF629 TFE3 CNTRL C5 PSMD5 CUTALP FBXW2 ENSG00000270917 TRAF1 DAB2IP lnc-TRAF1-1
GH09J121050 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 621.8 +24.9 24901 1.5 GATAD2A RXRB SP1 CEBPA SOX13 CEBPB TCF7 TGIF2 ATF3 YY1 C5 CNTRL CUTALP lnc-TRAF1-1 TRAF1
GH09J121198 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.6 -125.7 -125731 5.2 SP1 HNRNPL GATAD2A CTCF PRDM10 LEF1 IKZF1 KDM1A POLR2A NFRKB GSN lnc-GSN-3 RAB14 CUTALP C5 CNTRL ENSG00000239593 GSN-AS1 FBXW2 ENSG00000227355
GH09J121120 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 -46.9 -46913 3.4 SP1 TEAD4 PRDM10 REST RFX1 CTCF POLR2A JUND PRDM1 DDX20 CNTRL CUTALP C5 RF00017-7857 piR-61240-305 GSN
GH09J121267 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -195.5 -195489 6.3 PRDM10 KDM1A ZNF692 FOXA1 RBFOX2 REST POLR2A GTF2F1 SCRT2 KMT2B GSN PSMD5 CNTRL FBXW2 RAB14 CUTALP MRRF STOM ENSG00000227355 C5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C5

Top Transcription factor binding sites by QIAGEN in the C5 gene promoter:
  • HNF-1
  • HNF-1A
  • POU2F1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for C5 Gene

Genomic Locations for C5 Gene
chr9:120,952,335-121,074,865
(GRCh38/hg38)
Size:
122,531 bases
Orientation:
Minus strand
chr9:123,714,613-123,812,554
(GRCh37/hg19)
Size:
97,942 bases
Orientation:
Minus strand

Genomic View for C5 Gene

Genes around C5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5 Gene

Proteins for C5 Gene

  • Protein details for C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01031-CO5_HUMAN
    Recommended name:
    Complement C5
    Protein Accession:
    P01031
    Secondary Accessions:
    • Q14CJ0
    • Q27I61

    Protein attributes for C5 Gene

    Size:
    1676 amino acids
    Molecular mass:
    188305 Da
    Quaternary structure:
    • C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). The C5a anaphylatoxin interacts with C5AR1. Interacts with tick complement inhibitor.
    • (Microbial infection) Interacts with Staphylococcus aureus protein SSL5.

    Three dimensional structures from OCA and Proteopedia for C5 Gene

neXtProt entry for C5 Gene

Post-translational modifications for C5 Gene

  • Glycosylation at Asn741, Asn911, Asn1115, and Asn1630
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for C5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Invitrogen Antibodies for C5 (AFLGC-C5)

No data available for DME Specific Peptides for C5 Gene

Domains & Families for C5 Gene

Gene Families for C5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for C5 Gene

Suggested Antigen Peptide Sequences for C5 Gene

GenScript: Design optimal peptide antigens:
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 (CO5_HUMAN)
genes like me logo Genes that share domains with C5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C5 Gene

Function for C5 Gene

Molecular function for C5 Gene

UniProtKB/Swiss-Prot Function:
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
UniProtKB/Swiss-Prot Function:
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
GENATLAS Biochemistry:
complement component 5,glycoprotein,180kDa,initiating after activation the assembly of the late complement components C5-C9,into the membrane attack complex

Phenotypes From GWAS Catalog for C5 Gene

Gene Ontology (GO) - Molecular Function for C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity IEA --
GO:0005102 signaling receptor binding TAS 9590258
GO:0005515 protein binding IPI 21217642
GO:0008009 chemokine activity TAS 10820279
genes like me logo Genes that share ontologies with C5: view
genes like me logo Genes that share phenotypes with C5: view

Human Phenotype Ontology for C5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for C5 Gene

MGI Knock Outs for C5:
  • Hc Hc<tm1b(EUCOMM)Wtsi>

Animal Model Products

miRNA for C5 Gene

miRTarBase miRNAs that target C5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for C5 Gene

Localization for C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 3
cytoskeleton 2
nucleus 2
cytosol 2
lysosome 2
mitochondrion 1
endosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005579 membrane attack complex IEA,IDA 22832194
GO:0005615 extracellular space TAS 9218605
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with C5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C5 Gene

Pathways & Interactions for C5 Gene

PathCards logo

SuperPathways for C5 Gene

SuperPathway Contained pathways
1 Immune response Lectin induced complement pathway
.56
.56
.55
2 Peptide ligand-binding receptors
3 Complement Pathway
.62
.01
.01
.01
4 Signaling by GPCR
5 Creation of C4 and C2 activators
genes like me logo Genes that share pathways with C5: view

Pathways by source for C5 Gene

3 GeneGo (Thomson Reuters) pathways for C5 Gene
  • Immune response Alternative complement pathway
  • Immune response Classical complement pathway
  • Immune response Lectin induced complement pathway
4 Qiagen pathways for C5 Gene
  • Alternative Complement Pathway
  • Classical Complement Pathway
  • Complement Pathway
  • Lectin Induced Complement Pathway

SIGNOR curated interactions for C5 Gene

Activates:

Gene Ontology (GO) - Biological Process for C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 7649993
GO:0002376 immune system process IEA --
GO:0006935 chemotaxis TAS 10820279
GO:0006954 inflammatory response TAS,IEA --
GO:0006956 complement activation IEA --
genes like me logo Genes that share ontologies with C5: view

Drugs & Compounds for C5 Gene

(10) Drugs for C5 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Eculizumab Approved, Investigational Pharma Target, antibody 0
Copper Approved, Investigational Pharma Target 249
Human immunoglobulin G Approved, Investigational Pharma Target, binder 0
Ravulizumab Approved, Investigational Pharma Target, inhibitor 14
Zinc Approved, Investigational Pharma Target 1594

(2) Additional Compounds for C5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with C5: view

Transcripts for C5 Gene

mRNA/cDNA for C5 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for C5 Gene

No ASD Table

Relevant External Links for C5 Gene

GeneLoc Exon Structure for
C5

Expression for C5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5 Gene

mRNA differential expression in normal tissues according to GTEx for C5 Gene

This gene is overexpressed in Liver (x33.4).

Protein differential expression in normal tissues from HIPED for C5 Gene

This gene is overexpressed in Serum (30.1), Plasma (15.2), and Synovial fluid (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5 Gene



Protein tissue co-expression partners for C5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C5

SOURCE GeneReport for Unigene cluster for C5 Gene:

Hs.494997

Evidence on tissue expression from TISSUES for C5 Gene

  • Bone marrow(4.3)
  • Liver(4.1)
  • Kidney(3.2)
  • Intestine(3.1)
  • Heart(2.8)
  • Blood(2.8)
  • Adrenal gland(2.6)
  • Gall bladder(2.5)
  • Nervous system(2.2)
  • Skin(2.2)
  • Spleen(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for C5 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • meninges
  • mouth
  • neck
  • pharynx
Thorax:
  • esophagus
  • heart
  • lung
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • fallopian tube
  • ovary
  • prostate
  • rectum
  • testicle
  • urethra
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • lymph node
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with C5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C5 Gene

Orthologs for C5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C5 30 31
  • 99.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia C5 30 31
  • 85.14 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hc 30 17 31
  • 81.13 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C5 30 31
  • 79.87 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C5 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C5 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C5 30 31
  • 63.65 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c5 30
  • 55.34 (n)
Zebrafish
(Danio rerio)
Actinopterygii c5 30 31
  • 51.05 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
ManyToMany
CSA.4097 31
  • 20 (a)
ManyToMany
Species where no ortholog for C5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C5 Gene

ENSEMBL:
Gene Tree for C5 (if available)
TreeFam:
Gene Tree for C5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C5: view image

Paralogs for C5 Gene

Paralogs for C5 Gene

(1) SIMAP similar genes for C5 Gene using alignment to 2 proteins:

  • CO5_HUMAN
  • U6BZC6_HUMAN
genes like me logo Genes that share paralogs with C5: view

Variants for C5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for C5 Gene

CO5_HUMAN-P01031
C5 variants are responsible for poor response to eculizumab [MIM:615749]. Eculizumab is a monoclonal antibody highly effective in reducing intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria. It specifically binds to the terminal complement protein C5, inhibits its cleavage into C5a and C5b, and prevents the formations of the cytolytic complement pore (PubMed:24521109).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
709557 Benign: not provided 120,982,742(-) A/G SYNONYMOUS_VARIANT
717915 Benign: not provided 120,989,689(-) C/G MISSENSE_VARIANT
718720 Benign: not provided 120,989,624(-) A/G MISSENSE_VARIANT
721799 Likely Benign: not provided 121,008,484(-) A/G SYNONYMOUS_VARIANT
722488 Likely Benign: not provided 120,953,846(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for C5 Gene

Structural Variations from Database of Genomic Variants (DGV) for C5 Gene

Variant ID Type Subtype PubMed ID
esv2759713 CNV loss 17122850
esv3573378 CNV loss 25503493
nsv507529 OTHER sequence alteration 20534489

Variation tolerance for C5 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.54; 97.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C5 Gene

Human Gene Mutation Database (HGMD)
C5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5

SNP Genotyping and Copy Number Assay Products

Disorders for C5 Gene

MalaCards: The human disease database

(19) MalaCards diseases for C5 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
complement component 5 deficiency
  • c5d
eculizumab, poor response to
leiner disease
  • complement component 5 deficiency
immunodeficiency due to a late component of complement deficiency
  • immunodeficiency due to c5 to c9 component complement deficiency
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
- elite association - COSMIC cancer census association via MalaCards
Search C5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CO5_HUMAN
  • Complement component 5 deficiency (C5D) [MIM:609536]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele. {ECO:0000269 PubMed:15995705}.

Genatlas disease for C5 Gene

neisserial recurrent infections,lupus systemic syndrome

Additional Disease Information for C5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with C5: view

Publications for C5 Gene

  1. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. (PMID: 15278436) Hasegawa K … Suzuki Y (Human genetics 2004) 3 23 41
  2. Genetic variants in C5 and poor response to eculizumab. (PMID: 24521109) Nishimura J … Kanakura Y (The New England journal of medicine 2014) 3 4
  3. Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. (PMID: 21217642) Laursen NS … Andersen GR (The EMBO journal 2011) 3 4
  4. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 41
  5. Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1. (PMID: 20797713) Sundqvist J … D'Hooghe TM (Fertility and sterility 2011) 3 41

Products for C5 Gene

Sources for C5 Gene