This gene encodes a small, conserved protein of unknown function that is expressed in a variety of tissues. There are pseudogenes for this gene on chromosomes 6, 8, 16, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013] See more...

Aliases for C4orf46 Gene

Aliases for C4orf46 Gene

  • Chromosome 4 Open Reading Frame 46 2 3 5
  • RCDG1 2 3 4
  • Renal Cancer Differentiation Gene 1 Protein 3 4
  • Renal Cancer Differentiation Gene 1 2
  • LOC201725 2
  • C4orf46 5

External Ids for C4orf46 Gene

Previous GeneCards Identifiers for C4orf46 Gene

  • GC04M159808
  • GC04M159587
  • GC04M155337

Summaries for C4orf46 Gene

Entrez Gene Summary for C4orf46 Gene

  • This gene encodes a small, conserved protein of unknown function that is expressed in a variety of tissues. There are pseudogenes for this gene on chromosomes 6, 8, 16, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

GeneCards Summary for C4orf46 Gene

C4orf46 (Chromosome 4 Open Reading Frame 46) is a Protein Coding gene.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C4orf46 Gene

Genomics for C4orf46 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C4orf46 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C4orf46 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C4orf46

Top Transcription factor binding sites by QIAGEN in the C4orf46 gene promoter:
  • C/EBPbeta
  • Cart-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Pbx1a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for C4orf46 Gene

Latest Assembly
chr4:158,666,675-158,672,255
(GRCh38/hg38)
Size:
5,581 bases
Orientation:
Minus strand

Previous Assembly
chr4:159,587,827-159,593,208
(GRCh37/hg19 by Entrez Gene)
Size:
5,382 bases
Orientation:
Minus strand

chr4:159,587,831-159,593,407
(GRCh37/hg19 by Ensembl)
Size:
5,577 bases
Orientation:
Minus strand

Genomic View for C4orf46 Gene

Genes around C4orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf46 Gene

Proteins for C4orf46 Gene

  • Protein details for C4orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504U0-CD046_HUMAN
    Recommended name:
    Renal cancer differentiation gene 1 protein
    Protein Accession:
    Q504U0
    Secondary Accessions:
    • B3KNH7

    Protein attributes for C4orf46 Gene

    Size:
    113 amino acids
    Molecular mass:
    11899 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf46 Gene

Post-translational modifications for C4orf46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C4orf46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C4orf46 Gene

Domains & Families for C4orf46 Gene

Gene Families for C4orf46 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf46 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C4orf46: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C4orf46 Gene

Function for C4orf46 Gene

Phenotypes From GWAS Catalog for C4orf46 Gene

Gene Ontology (GO) - Molecular Function for C4orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C4orf46: view
genes like me logo Genes that share phenotypes with C4orf46: view

miRNA for C4orf46 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C4orf46

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf46 Gene

Localization for C4orf46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C4orf46 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf46 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
golgi apparatus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C4orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with C4orf46: view

Pathways & Interactions for C4orf46 Gene

PathCards logo

SuperPathways for C4orf46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C4orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf46 Gene

Drugs & Compounds for C4orf46 Gene

No Compound Related Data Available

Transcripts for C4orf46 Gene

mRNA/cDNA for C4orf46 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C4orf46

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf46 Gene

No ASD Table

Relevant External Links for C4orf46 Gene

GeneLoc Exon Structure for
C4orf46

Expression for C4orf46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C4orf46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C4orf46 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C4orf46 Gene



Protein tissue co-expression partners for C4orf46 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C4orf46

SOURCE GeneReport for Unigene cluster for C4orf46 Gene:

Hs.380920

mRNA Expression by UniProt/SwissProt for C4orf46 Gene:

Q504U0-CD046_HUMAN
Tissue specificity: Expressed in the kidney, in epithelial cells in both proximal tubules and distal convoluted tubules.

Evidence on tissue expression from TISSUES for C4orf46 Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with C4orf46: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf46 Gene

Orthologs for C4orf46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4orf46 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C4orf46 31
  • 100 (a)
OneToOne
C4H4orf46 30
  • 99.71 (n)
Rat
(Rattus norvegicus)
Mammalia RGD1560010 30
  • 89.17 (n)
Cow
(Bos Taurus)
Mammalia C17H4orf46 30 31
  • 88.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia 4930579G24Rik 30 17 31
  • 88.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C15H4orf46 30
  • 87.61 (n)
C4orf46 31
  • 84 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C4orf46 31
  • 60 (a)
OneToOne
Species where no ortholog for C4orf46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C4orf46 Gene

ENSEMBL:
Gene Tree for C4orf46 (if available)
TreeFam:
Gene Tree for C4orf46 (if available)

Paralogs for C4orf46 Gene

Pseudogenes.org Pseudogenes for C4orf46 Gene

genes like me logo Genes that share paralogs with C4orf46: view

No data available for Paralogs for C4orf46 Gene

Variants for C4orf46 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C4orf46 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
974730 Uncertain Significance: Aganglionic megacolon 158,620,033(-) ACTCAGATTTTACAAC
NG_031835.1(PPID):g.103322_138659del

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C4orf46 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C4orf46 Gene

Variant ID Type Subtype PubMed ID
esv2728610 CNV deletion 23290073
esv3602837 CNV gain 21293372

Variation tolerance for C4orf46 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C4orf46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf46

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf46 Gene

Disorders for C4orf46 Gene

Additional Disease Information for C4orf46

No disorders were found for C4orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf46 Gene

Publications for C4orf46 Gene

  1. Expression and clinical significance of RCDG1 in renal cell carcinoma: a novel renal cancer‑associated gene. (PMID: 25059753) Yu Z … Lai Y (Molecular medicine reports 2014) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3

Products for C4orf46 Gene

Sources for C4orf46 Gene