Aliases for C4orf36 Gene

Aliases for C4orf36 Gene

  • Chromosome 4 Open Reading Frame 36 2 3 5
  • Uncharacterized Protein C4orf36 3 4
  • MGC26744 2
  • C4orf36 5

External Ids for C4orf36 Gene

Previous GeneCards Identifiers for C4orf36 Gene

  • GC04M088016
  • GC04M087797
  • GC04M083543

Summaries for C4orf36 Gene

GeneCards Summary for C4orf36 Gene

C4orf36 (Chromosome 4 Open Reading Frame 36) is a Protein Coding gene. An important paralog of this gene is ENSG00000285458.

Additional gene information for C4orf36 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C4orf36 Gene

Genomics for C4orf36 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C4orf36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C4orf36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C4orf36

Top Transcription factor binding sites by QIAGEN in the C4orf36 gene promoter:
  • Chx10
  • CUTL1
  • E4BP4
  • p53
  • POU2F1
  • POU2F1a
  • S8
  • YY1

Genomic Locations for C4orf36 Gene

Latest Assembly
chr4:86,876,205-86,897,256
(GRCh38/hg38)
Size:
21,052 bases
Orientation:
Minus strand

Previous Assembly
chr4:87,797,358-87,813,575
(GRCh37/hg19 by Entrez Gene)
Size:
16,218 bases
Orientation:
Minus strand

chr4:87,797,358-87,857,354
(GRCh37/hg19 by Ensembl)
Size:
59,997 bases
Orientation:
Minus strand

Genomic View for C4orf36 Gene

Genes around C4orf36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf36 Gene

Proteins for C4orf36 Gene

  • Protein details for C4orf36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KX1-CD036_HUMAN
    Recommended name:
    Uncharacterized protein C4orf36
    Protein Accession:
    Q96KX1

    Protein attributes for C4orf36 Gene

    Size:
    117 amino acids
    Molecular mass:
    13276 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf36 Gene

Post-translational modifications for C4orf36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C4orf36 Gene

Domains & Families for C4orf36 Gene

Gene Families for C4orf36 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf36 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C4orf36: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C4orf36 Gene

Function for C4orf36 Gene

Phenotypes From GWAS Catalog for C4orf36 Gene

genes like me logo Genes that share phenotypes with C4orf36: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C4orf36

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf36 Gene

Localization for C4orf36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf36 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C4orf36 Gene

Pathways & Interactions for C4orf36 Gene

PathCards logo

SuperPathways for C4orf36 Gene

No Data Available

Interacting Proteins for C4orf36 Gene

Gene Ontology (GO) - Biological Process for C4orf36 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf36 Gene

Drugs & Compounds for C4orf36 Gene

No Compound Related Data Available

Transcripts for C4orf36 Gene

mRNA/cDNA for C4orf36 Gene

3 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C4orf36

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf36 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
SP1: - - -
SP2: -
SP3: - - -
SP4: - -

Relevant External Links for C4orf36 Gene

GeneLoc Exon Structure for
C4orf36

Expression for C4orf36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C4orf36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for C4orf36 Gene

This gene is overexpressed in Uterus (8.3), Spleen (6.7), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C4orf36 Gene



Protein tissue co-expression partners for C4orf36 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C4orf36

SOURCE GeneReport for Unigene cluster for C4orf36 Gene:

Hs.339646
genes like me logo Genes that share expression patterns with C4orf36: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf36 Gene

Orthologs for C4orf36 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4orf36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C4orf36 31
  • 99 (a)
OneToOne
C4H4orf36 30
  • 98.86 (n)
Cow
(Bos Taurus)
Mammalia C6H4orf36 30
  • 81.77 (n)
Dog
(Canis familiaris)
Mammalia C4orf36 31
  • 74 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 1700016H13Rik 30 17 31
  • 71.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC498330 30
  • 70.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia C4orf36 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C4orf36 31
  • 34 (a)
OneToOne
Species where no ortholog for C4orf36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C4orf36 Gene

ENSEMBL:
Gene Tree for C4orf36 (if available)
TreeFam:
Gene Tree for C4orf36 (if available)

Paralogs for C4orf36 Gene

Paralogs for C4orf36 Gene

genes like me logo Genes that share paralogs with C4orf36: view

Variants for C4orf36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C4orf36 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11938345 - p.Ser18Asn
rs1550931 - p.Ser36Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C4orf36 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C4orf36 Gene

Variant ID Type Subtype PubMed ID
nsv1013308 CNV gain 25217958
nsv508297 CNV deletion 20534489
nsv594787 CNV gain 21841781
nsv967771 CNV duplication 23825009

Variation tolerance for C4orf36 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C4orf36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf36

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf36 Gene

Disorders for C4orf36 Gene

Additional Disease Information for C4orf36

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C4orf36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf36 Gene

Publications for C4orf36 Gene

  1. A high-density genome-wide association screen of sporadic ALS in US veterans. (PMID: 22470424) Kwee LC … Hauser MA (PloS one 2012) 3 41
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3

Products for C4orf36 Gene

Sources for C4orf36 Gene