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Aliases for C4orf33 Gene

Aliases for C4orf33 Gene

  • Chromosome 4 Open Reading Frame 33 2 3 5
  • UPF0462 Protein C4orf33 3

External Ids for C4orf33 Gene

Previous GeneCards Identifiers for C4orf33 Gene

  • GC04P130234
  • GC04P130014
  • GC04P125745

Summaries for C4orf33 Gene

GeneCards Summary for C4orf33 Gene

C4orf33 (Chromosome 4 Open Reading Frame 33) is a Protein Coding gene.

Additional gene information for C4orf33 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf33 Gene

Genomics for C4orf33 Gene

GeneHancer (GH) Regulatory Elements for C4orf33 Gene

Promoters and enhancers for C4orf33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J129091 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 668.6 +1.0 1011 5.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B C4orf33 SCLT1 JADE1 LOC100127912
GH04J128808 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.9 -281.7 -281664 5.5 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC JADE1 MFSD8 C4orf33 PIR40738
GH04J128916 Enhancer 1.3 FANTOM5 Ensembl ENCODE 25.4 -175.7 -175744 2.5 HDGF PKNOX1 BMI1 BATF IRF4 ZNF207 ATF7 BCLAF1 IKZF2 RUNX3 SCLT1 C4orf33 JADE1 ENSG00000275647 PIR40738
GH04J128957 Enhancer 1 Ensembl ENCODE 23.8 -135.1 -135077 0.9 FOXA2 RARA ZNF614 CREM MIXL1 HMG20B CEBPB ELF1 PPARG NFIL3 C4orf33 SCLT1 ENSG00000275647 ENSG00000281369
GH04J128858 Enhancer 0.9 ENCODE dbSUPER 17.6 -233.7 -233697 2.8 HDGF SUZ12 ZSCAN4 STAT5A POLR2A PHF20 EED FOS RUNX3 CREM C4orf33 JADE1 SCLT1 PIR40738 ENSG00000275647
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C4orf33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C4orf33 gene promoter:
  • Pax-3
  • deltaCREB
  • CREB

Genomic Locations for C4orf33 Gene

Genomic Locations for C4orf33 Gene
chr4:129,093,317-129,116,640
(GRCh38/hg38)
Size:
23,324 bases
Orientation:
Plus strand
chr4:130,014,472-130,037,795
(GRCh37/hg19)
Size:
23,324 bases
Orientation:
Plus strand

Genomic View for C4orf33 Gene

Genes around C4orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf33 Gene

Proteins for C4orf33 Gene

  • Protein details for C4orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1A6-CD033_HUMAN
    Recommended name:
    UPF0462 protein C4orf33
    Protein Accession:
    Q8N1A6
    Secondary Accessions:
    • D3DNY2
    • Q6PJF3
    • Q8NBC5

    Protein attributes for C4orf33 Gene

    Size:
    199 amino acids
    Molecular mass:
    23468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf33 Gene

Post-translational modifications for C4orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C4orf33 Gene

Domains & Families for C4orf33 Gene

Gene Families for C4orf33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C4orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1A6

UniProtKB/Swiss-Prot:

CD033_HUMAN :
  • Belongs to the UPF0462 family.
Family:
  • Belongs to the UPF0462 family.
genes like me logo Genes that share domains with C4orf33: view

Function for C4orf33 Gene

Phenotypes From GWAS Catalog for C4orf33 Gene

Gene Ontology (GO) - Molecular Function for C4orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C4orf33: view
genes like me logo Genes that share phenotypes with C4orf33: view

Animal Model Products

miRNA for C4orf33 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf33 Gene

Localization for C4orf33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf33 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C4orf33 Gene

Pathways & Interactions for C4orf33 Gene

SuperPathways for C4orf33 Gene

No Data Available

Interacting Proteins for C4orf33 Gene

Gene Ontology (GO) - Biological Process for C4orf33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf33 Gene

Drugs & Compounds for C4orf33 Gene

No Compound Related Data Available

Transcripts for C4orf33 Gene

Unigene Clusters for C4orf33 Gene

Chromosome 4 open reading frame 33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf33 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for C4orf33 Gene

GeneLoc Exon Structure for
C4orf33
ECgene alternative splicing isoforms for
C4orf33

Expression for C4orf33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C4orf33 Gene

Protein differential expression in normal tissues from HIPED for C4orf33 Gene

This gene is overexpressed in Oral epithelium (17.1), Spleen (13.4), Platelet (8.6), Pancreas (7.6), and Skin (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C4orf33 Gene



NURSA nuclear receptor signaling pathways regulating expression of C4orf33 Gene:

C4orf33

SOURCE GeneReport for Unigene cluster for C4orf33 Gene:

Hs.567679
genes like me logo Genes that share expression patterns with C4orf33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf33 Gene

Orthologs for C4orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C4orf33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf33 33
  • 98.83 (n)
C4orf33 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C17H4orf33 33
  • 91.79 (n)
C4orf33 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C19H4orf33 33
  • 90.62 (n)
C4orf33 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1359508 33
  • 87.27 (n)
mouse
(Mus musculus)
Mammalia D3Ertd751e 16 34 33
  • 85.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf33 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4orf33 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves C4ORF33 33
  • 73.44 (n)
C4orf33 34
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf33 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c4orf33 33
  • 67.7 (n)
Str.17636 33
zebrafish
(Danio rerio)
Actinopterygii zgc:77739 33
  • 61.73 (n)
C1H4orf33 34
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11064 33
worm
(Caenorhabditis elegans)
Secernentea CELE_C33A12.3 33
  • 54.73 (n)
C33A12.3 34
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for C4orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C4orf33 Gene

ENSEMBL:
Gene Tree for C4orf33 (if available)
TreeFam:
Gene Tree for C4orf33 (if available)

Paralogs for C4orf33 Gene

(1) SIMAP similar genes for C4orf33 Gene using alignment to 4 proteins:

  • CD033_HUMAN
  • D6RD26_HUMAN
  • D6RIS3_HUMAN
  • D6RIT3_HUMAN

Pseudogenes.org Pseudogenes for C4orf33 Gene

genes like me logo Genes that share paralogs with C4orf33: view

No data available for Paralogs for C4orf33 Gene

Variants for C4orf33 Gene

Sequence variations from dbSNP and Humsavar for C4orf33 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000044094 -- 129,107,095(+) C/T intron_variant
rs1000513379 -- 129,112,270(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000857991 -- 129,093,234(+) C/T upstream_transcript_variant
rs1000911638 -- 129,093,447(+) G/A/C upstream_transcript_variant
rs1000916102 -- 129,109,128(+) A/G intron_variant

Variation tolerance for C4orf33 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C4orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C4orf33 Gene

Disorders for C4orf33 Gene

Additional Disease Information for C4orf33

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C4orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf33 Gene

Publications for C4orf33 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. A genome-wide association meta-analysis identifies new childhood obesity loci. (PMID: 22484627) Bradfield JP … Early Growth Genetics Consortium (Nature genetics 2012) 44 58

Products for C4orf33 Gene

Sources for C4orf33 Gene

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