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Aliases for C4orf22 Gene

Aliases for C4orf22 Gene

  • Chromosome 4 Open Reading Frame 22 2 3 5

External Ids for C4orf22 Gene

Previous GeneCards Identifiers for C4orf22 Gene

  • GC04P081475
  • GC04P081256
  • GC04P077000

Summaries for C4orf22 Gene

GeneCards Summary for C4orf22 Gene

C4orf22 (Chromosome 4 Open Reading Frame 22) is a Protein Coding gene.

Additional gene information for C4orf22 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf22 Gene

Genomics for C4orf22 Gene

GeneHancer (GH) Regulatory Elements for C4orf22 Gene

Promoters and enhancers for C4orf22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I080335 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.4 438 1.3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLIS2 E2F8 ZNF143 ATF7 SP3 C4orf22 LOC100419739 FGF5
GH04I080304 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -27.8 -27786 5.6 PKNOX1 ARNT FEZF1 ZNF2 ZNF213 KLF7 FOS SP3 REST TSHZ1 C4orf22 MRPS25P1 FGF5
GH04I080292 Enhancer 0.4 dbSUPER 22.8 -39.9 -39907 6.6 ZFHX2 POLR2A SCRT2 C4orf22 FGF5 BMP3 MRPS25P1
GH04I080321 Enhancer 0.5 dbSUPER 11.2 -12.5 -12530 2 CTCF ZNF654 ZNF680 REST FOS ZNF600 RAD21 MRPS25P1 C4orf22 FGF5
GH04I080492 Enhancer 0.5 ENCODE 11.1 +157.6 157563 1.3 CTBP1 SOX6 ZEB2 ZBTB40 GABPA LOC105377305 C4orf22 GC04P080582
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C4orf22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C4orf22 gene promoter:

Genomic Locations for C4orf22 Gene

Genomic Locations for C4orf22 Gene
chr4:80,335,326-80,963,756
(GRCh38/hg38)
Size:
628,431 bases
Orientation:
Plus strand
chr4:81,256,874-81,884,910
(GRCh37/hg19)

Genomic View for C4orf22 Gene

Genes around C4orf22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf22 Gene

Proteins for C4orf22 Gene

  • Protein details for C4orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6V702-CD022_HUMAN
    Recommended name:
    Uncharacterized protein C4orf22
    Protein Accession:
    Q6V702
    Secondary Accessions:
    • E7EQ13
    • Q6ZQY4
    • Q8N4G9

    Protein attributes for C4orf22 Gene

    Size:
    233 amino acids
    Molecular mass:
    26869 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C4orf22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C4orf22 Gene

Post-translational modifications for C4orf22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C4orf22 Gene

Domains & Families for C4orf22 Gene

Gene Families for C4orf22 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf22 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf22: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf22 Gene

Function for C4orf22 Gene

Phenotypes From GWAS Catalog for C4orf22 Gene

genes like me logo Genes that share phenotypes with C4orf22: view

Animal Models for C4orf22 Gene

MGI Knock Outs for C4orf22:

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C4orf22 Gene

Localization for C4orf22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf22 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C4orf22 Gene

Pathways & Interactions for C4orf22 Gene

SuperPathways for C4orf22 Gene

No Data Available

Interacting Proteins for C4orf22 Gene

Selected Interacting proteins: Q6V702-CD022_HUMAN for C4orf22 Gene via IID

Symbol External ID(s) Details
APP
BAG3

Gene Ontology (GO) - Biological Process for C4orf22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf22 Gene

Drugs & Compounds for C4orf22 Gene

No Compound Related Data Available

Transcripts for C4orf22 Gene

Unigene Clusters for C4orf22 Gene

Chromosome 4 open reading frame 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf22 Gene

No ASD Table

Relevant External Links for C4orf22 Gene

GeneLoc Exon Structure for
C4orf22
ECgene alternative splicing isoforms for
C4orf22

Expression for C4orf22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C4orf22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C4orf22 Gene

This gene is overexpressed in Testis (x23.9).

NURSA nuclear receptor signaling pathways regulating expression of C4orf22 Gene:

C4orf22

SOURCE GeneReport for Unigene cluster for C4orf22 Gene:

Hs.527104
genes like me logo Genes that share expression patterns with C4orf22: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf22 Gene

Orthologs for C4orf22 Gene

This gene was present in the common ancestor of animals.

Orthologs for C4orf22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf22 33
  • 99.2 (n)
C4orf22 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6H4orf22 33
  • 88.89 (n)
C4orf22 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C32H4orf22 33
  • 88.67 (n)
C4orf22 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700007G11Rik 33 16 34
  • 83.83 (n)
oppossum
(Monodelphis domestica)
Mammalia C4orf22 34
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685158 33
  • 74.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf22 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf22 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498045 33
  • 70.98 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-57h10.1 33
  • 63.62 (n)
C5H4orf22 34
  • 49 (a)
OneToOne
Dr.12493 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.274 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006170 33
  • 45.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8138 34
  • 30 (a)
OneToMany
CG14017 34
  • 28 (a)
OneToMany
CG3528 34
  • 28 (a)
OneToMany
CG14013 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8131 33
Species where no ortholog for C4orf22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C4orf22 Gene

ENSEMBL:
Gene Tree for C4orf22 (if available)
TreeFam:
Gene Tree for C4orf22 (if available)

Paralogs for C4orf22 Gene

genes like me logo Genes that share paralogs with C4orf22: view

No data available for Paralogs for C4orf22 Gene

Variants for C4orf22 Gene

Sequence variations from dbSNP and Humsavar for C4orf22 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000004217 -- 80,381,752(+) C/G genic_upstream_transcript_variant, intron_variant
rs10000078 -- 80,733,827(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000012730 -- 80,760,740(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000017836 -- 80,620,711(+) C/T intron_variant
rs1000024320 -- 80,920,016(+) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C4orf22 Gene

Variant ID Type Subtype PubMed ID
dgv155n6 CNV deletion 16902084
dgv2834n106 CNV deletion 24896259
dgv2835n106 CNV deletion 24896259
dgv2836n106 CNV deletion 24896259
esv1003054 CNV deletion 20482838
esv1761835 CNV deletion 17803354
esv1772075 CNV deletion 17803354
esv2012478 CNV deletion 18987734
esv22804 CNV loss 19812545
esv2287638 CNV deletion 18987734
esv2437571 CNV deletion 19546169
esv2458804 CNV deletion 19546169
esv2557088 CNV deletion 19546169
esv2659472 CNV deletion 23128226
esv2660580 CNV deletion 23128226
esv2661892 CNV deletion 23128226
esv2668568 CNV deletion 23128226
esv2727868 CNV deletion 23290073
esv2727869 CNV deletion 23290073
esv2727870 CNV deletion 23290073
esv2727871 CNV deletion 23290073
esv2727872 CNV deletion 23290073
esv2763370 CNV gain 21179565
esv29813 CNV loss 19812545
esv3564134 CNV deletion 23714750
esv3564135 CNV deletion 23714750
esv3564136 CNV deletion 23714750
esv3564138 CNV deletion 23714750
esv3569534 CNV loss 25503493
esv3569535 CNV loss 25503493
esv3575755 CNV gain 25503493
esv3601136 CNV loss 21293372
esv3601138 CNV loss 21293372
esv3601139 CNV loss 21293372
esv3601140 CNV gain 21293372
esv3601141 CNV gain 21293372
esv3601142 CNV loss 21293372
esv3601143 CNV gain 21293372
esv3707 CNV loss 18987735
esv3893966 CNV loss 25118596
esv4973 CNV loss 18987735
esv8483 CNV loss 19470904
esv996118 CNV deletion 20482838
nsv1013945 CNV loss 25217958
nsv1073346 CNV deletion 25765185
nsv1073347 CNV deletion 25765185
nsv1114548 CNV deletion 24896259
nsv1121628 CNV deletion 24896259
nsv1125818 CNV tandem duplication 24896259
nsv1139275 CNV deletion 24896259
nsv1141810 CNV insertion 24896259
nsv1143098 CNV tandem duplication 24896259
nsv1145996 CNV insertion 26484159
nsv1147567 CNV deletion 26484159
nsv293578 CNV deletion 16902084
nsv4401 CNV insertion 18451855
nsv472244 CNV novel sequence insertion 20440878
nsv517072 CNV loss 19592680
nsv517603 CNV loss 19592680
nsv525865 CNV loss 19592680
nsv528410 CNV loss 19592680
nsv955663 CNV deletion 24416366
nsv955669 CNV deletion 24416366

Variation tolerance for C4orf22 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C4orf22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf22 Gene

Disorders for C4orf22 Gene

Additional Disease Information for C4orf22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C4orf22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf22 Gene

Publications for C4orf22 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58

Products for C4orf22 Gene

Sources for C4orf22 Gene

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