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Aliases for C4orf19 Gene

Aliases for C4orf19 Gene

  • Chromosome 4 Open Reading Frame 19 2 3 5

External Ids for C4orf19 Gene

Previous GeneCards Identifiers for C4orf19 Gene

  • GC04P037131
  • GC04P036779

Summaries for C4orf19 Gene

GeneCards Summary for C4orf19 Gene

C4orf19 (Chromosome 4 Open Reading Frame 19) is a Protein Coding gene.

Additional gene information for C4orf19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf19 Gene

Genomics for C4orf19 Gene

GeneHancer (GH) Regulatory Elements for C4orf19 Gene

Promoters and enhancers for C4orf19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I037452 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 561.3 +1.6 1584 5 SIN3A YY1 GLIS2 ZNF143 ZNF548 RXRA NFYC REST MAFF MXD3 C4orf19 ENSG00000248936
GH04I037582 Promoter/Enhancer 0.9 EPDnew ENCODE 567.1 +130.5 130470 2.4 FOXA2 FOXA3 C4orf19 RELL1 ENSG00000248936
GH04I037561 Enhancer 0.9 ENCODE 16.2 +108.6 108570 0.2 ATF1 FEZF1 IRF4 TCF12 FOS ATF7 JUNB TSHZ1 MEF2D SMARCA4 C4orf19 ENSG00000248936
GH04I037429 Enhancer 1.1 ENCODE dbSUPER 12 -22.7 -22654 3.1 ELF3 FOXA2 ARID4B FEZF1 RARA YY1 SCRT2 ATF7 IKZF2 THAP11 C4orf19 NWD2
GH04I037728 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 +276.2 276150 2.3 ELF3 FOXA2 ARID4B RAD21 THRB ZSCAN9 RARA CREM MIXL1 HMG20B RELL1 C4orf19 LOC105374404 LOC105374406
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C4orf19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C4orf19 gene promoter:

Genomic Locations for C4orf19 Gene

Genomic Locations for C4orf19 Gene
170,042 bases
Plus strand

Genomic View for C4orf19 Gene

Genes around C4orf19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf19 Gene

Proteins for C4orf19 Gene

  • Protein details for C4orf19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C4orf19
    Protein Accession:
    Secondary Accessions:
    • Q9NV03

    Protein attributes for C4orf19 Gene

    314 amino acids
    Molecular mass:
    33742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf19 Gene

Post-translational modifications for C4orf19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C4orf19 Gene

No data available for DME Specific Peptides for C4orf19 Gene

Domains & Families for C4orf19 Gene

Gene Families for C4orf19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf19 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf19: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf19 Gene

Function for C4orf19 Gene

Gene Ontology (GO) - Molecular Function for C4orf19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C4orf19: view

Phenotypes for C4orf19 Gene

genes like me logo Genes that share phenotypes with C4orf19: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf19 Gene

Localization for C4orf19 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf19 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C4orf19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with C4orf19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C4orf19 Gene

Pathways & Interactions for C4orf19 Gene

SuperPathways for C4orf19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C4orf19 Gene


No data available for Pathways by source and SIGNOR curated interactions for C4orf19 Gene

Drugs & Compounds for C4orf19 Gene

No Compound Related Data Available

Transcripts for C4orf19 Gene

Unigene Clusters for C4orf19 Gene

Chromosome 4 open reading frame 19:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf19 Gene

No ASD Table

Relevant External Links for C4orf19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C4orf19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C4orf19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C4orf19 Gene

This gene is overexpressed in Pancreas (x7.1) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for C4orf19 Gene

This gene is overexpressed in Heart (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C4orf19 Gene

Protein tissue co-expression partners for C4orf19 Gene

NURSA nuclear receptor signaling pathways regulating expression of C4orf19 Gene:


SOURCE GeneReport for Unigene cluster for C4orf19 Gene:


Evidence on tissue expression from TISSUES for C4orf19 Gene

  • Liver(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with C4orf19: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf19 Gene

Orthologs for C4orf19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C4orf19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C4H4orf19 33
  • 99.58 (n)
C4orf19 34
  • 99 (a)
(Bos Taurus)
Mammalia C6H4orf19 33
  • 73.04 (n)
C4orf19 34
  • 59 (a)
(Mus musculus)
Mammalia 0610040J01Rik 33 16 34
  • 72.06 (n)
(Rattus norvegicus)
Mammalia LOC498368 33
  • 70.74 (n)
(Monodelphis domestica)
Mammalia C4orf19 34
  • 40 (a)
(Canis familiaris)
Mammalia C4orf19 34
  • 37 (a)
(Gallus gallus)
Aves C4orf19 34
  • 32 (a)
(Anolis carolinensis)
Reptilia C4orf19 34
  • 22 (a)
Species where no ortholog for C4orf19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf19 Gene

Gene Tree for C4orf19 (if available)
Gene Tree for C4orf19 (if available)

Paralogs for C4orf19 Gene

(5) SIMAP similar genes for C4orf19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C4orf19: view

No data available for Paralogs for C4orf19 Gene

Variants for C4orf19 Gene

Sequence variations from dbSNP and Humsavar for C4orf19 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000026101 -- 37,559,641(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000077403 -- 37,484,266(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000088711 -- 37,454,071(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000128089 -- 37,568,201(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000168069 -- 37,463,038(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C4orf19 Gene

Variant ID Type Subtype PubMed ID
dgv2771n106 CNV deletion 24896259
esv1036244 CNV deletion 17803354
esv21522 CNV loss 19812545
esv2254243 CNV deletion 18987734
esv2656828 CNV deletion 23128226
esv2674540 CNV deletion 23128226
esv2677154 CNV deletion 23128226
esv2727430 CNV deletion 23290073
esv2727431 CNV deletion 23290073
esv3301717 CNV deletion 24192839
esv3563712 CNV deletion 23714750
esv3563714 CNV deletion 23714750
esv3600245 CNV loss 21293372
esv3600246 CNV loss 21293372
esv3600247 CNV loss 21293372
esv999359 CNV deletion 20482838
nsv1114510 CNV deletion 24896259
nsv1123773 CNV deletion 24896259
nsv1124889 CNV duplication 24896259
nsv1125805 CNV tandem duplication 24896259
nsv4303 CNV insertion 18451855
nsv521553 CNV loss 19592680
nsv822534 CNV loss 20364138
nsv829909 CNV loss 17160897
nsv997413 CNV gain 25217958

Variation tolerance for C4orf19 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C4orf19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf19 Gene

Disorders for C4orf19 Gene

Additional Disease Information for C4orf19

No disorders were found for C4orf19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf19 Gene

Publications for C4orf19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for C4orf19 Gene

Sources for C4orf19 Gene

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