Aliases for C4orf50 Gene

Aliases for C4orf50 Gene

  • Chromosome 4 Open Reading Frame 50 2 3 5
  • Uncharacterized Protein C4orf50 3 4

External Ids for C4orf50 Gene

Previous GeneCards Identifiers for C4orf50 Gene

  • GC04M006009
  • GC04M005899
  • GC04M005958

Summaries for C4orf50 Gene

GeneCards Summary for C4orf50 Gene

C4orf50 (Chromosome 4 Open Reading Frame 50) is a Protein Coding gene.

Additional gene information for C4orf50 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C4orf50 Gene

Genomics for C4orf50 Gene

GeneHancer (GH) Regulatory Elements for C4orf50 Gene

Promoters and enhancers for C4orf50 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J006197 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.7 701 4.7 SIN3A NRF1 USF1 SP1 RBAK ZBTB26 REST KLF4 CTBP1 NFYB JAKMIP1 C4orf50 LINC02495 piR-43105-478
GH04J005955 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 11.9 +244.9 244935 3.8 USF1 ZIC2 GABPA RBM25 OSR2 RELA ZNF316 MAFF ZKSCAN1 SRF C4orf50 piR-45517-005 lnc-EVC-3
GH04J006097 Enhancer 0.3 Ensembl 11.1 +102.9 102854 0.6 SPI1 C4orf50 ENSG00000251408 JAKMIP1 LINC02495 ENSG00000284684 ENSG00000287786
GH04J006177 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +19.5 19454 7.8 RXRA ZBTB40 SIN3A SP1 EP300 JUND RELA MEF2C RCOR1 REST JAKMIP1 ENSG00000287786 piR-43105-478 C4orf50
GH04J006188 Enhancer 0.7 Ensembl ENCODE dbSUPER 0.4 +11.3 11300 1.2 MXI1 ZNF189 RCOR1 JAKMIP1 piR-43105-478 C4orf50
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C4orf50 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C4orf50 gene promoter:
  • AP-4
  • AREB6
  • E47
  • Lhx3a
  • LHX3b
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1
  • ZID

Genomic Locations for C4orf50 Gene

Genomic Locations for C4orf50 Gene
chr4:5,897,373-6,200,555
(GRCh38/hg38)
Size:
303,183 bases
Orientation:
Minus strand
chr4:5,958,839-5,991,545
(GRCh37/hg19)
Size:
32,707 bases
Orientation:
Minus strand

Genomic View for C4orf50 Gene

Genes around C4orf50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf50 Gene

Proteins for C4orf50 Gene

  • Protein details for C4orf50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRC1-CD050_HUMAN
    Recommended name:
    Uncharacterized protein C4orf50
    Protein Accession:
    Q6ZRC1

    Protein attributes for C4orf50 Gene

    Size:
    276 amino acids
    Molecular mass:
    30622 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf50 Gene

Post-translational modifications for C4orf50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C4orf50 Gene

Domains & Families for C4orf50 Gene

Gene Families for C4orf50 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf50 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C4orf50: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C4orf50 Gene

Function for C4orf50 Gene

Phenotypes From GWAS Catalog for C4orf50 Gene

genes like me logo Genes that share phenotypes with C4orf50: view

Animal Model Products

CRISPR Products

miRNA for C4orf50 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf50 Gene

Localization for C4orf50 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf50 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C4orf50 Gene

Pathways & Interactions for C4orf50 Gene

PathCards logo

SuperPathways for C4orf50 Gene

No Data Available

Interacting Proteins for C4orf50 Gene

;

Gene Ontology (GO) - Biological Process for C4orf50 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf50 Gene

Drugs & Compounds for C4orf50 Gene

No Compound Related Data Available

Transcripts for C4orf50 Gene

mRNA/cDNA for C4orf50 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf50 Gene

No ASD Table

Relevant External Links for C4orf50 Gene

GeneLoc Exon Structure for
C4orf50

Expression for C4orf50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C4orf50 Gene

mRNA differential expression in normal tissues according to GTEx for C4orf50 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x11.4), Brain - Frontal Cortex (BA9) (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Caudate (basal ganglia) (x5.2), Brain - Cortex (x4.9), and Brain - Putamen (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for C4orf50 Gene

This gene is overexpressed in Lung (61.7) and CD4 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C4orf50 Gene



Protein tissue co-expression partners for C4orf50 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C4orf50

SOURCE GeneReport for Unigene cluster for C4orf50 Gene:

Hs.479065
genes like me logo Genes that share expression patterns with C4orf50: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf50 Gene

Orthologs for C4orf50 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4orf50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC750617 30
  • 98.87 (n)
C4orf50 31
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102553825 30
  • 65.35 (n)
dog
(Canis familiaris)
Mammalia C4orf50 31
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm1043 17 31 30
  • 63.81 (n)
cow
(Bos Taurus)
Mammalia C4orf50 31
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4orf50 31
  • 13 (a)
OneToOne
Species where no ortholog for C4orf50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf50 Gene

ENSEMBL:
Gene Tree for C4orf50 (if available)
TreeFam:
Gene Tree for C4orf50 (if available)

Paralogs for C4orf50 Gene

(1) SIMAP similar genes for C4orf50 Gene using alignment to 2 proteins:

  • CD050_HUMAN
  • E9PNW5_HUMAN
genes like me logo Genes that share paralogs with C4orf50: view

No data available for Paralogs for C4orf50 Gene

Variants for C4orf50 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C4orf50 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
VAR_042681 A breast cancer sample p.Ala150Pro
rs16837960 - p.Arg86Trp
rs6839295 - p.Ile177Val
rs7695618 - p.Val199Met

Additional dbSNP identifiers (rs#s) for C4orf50 Gene

Variation tolerance for C4orf50 Gene

Gene Damage Index Score: 11.89; 93.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C4orf50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C4orf50 Gene

Disorders for C4orf50 Gene

Additional Disease Information for C4orf50

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C4orf50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf50 Gene

Publications for C4orf50 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans DM … Whitfield JB (Human molecular genetics 2013) 3 54
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for C4orf50 Gene

Sources for C4orf50 Gene