Aliases for C3orf70 Gene

Aliases for C3orf70 Gene

  • Chromosome 3 Open Reading Frame 70 2 3 5
  • UPF0524 Protein C3orf70 3 4

External Ids for C3orf70 Gene

Previous GeneCards Identifiers for C3orf70 Gene

  • GC03M186278
  • GC03M184795
  • GC03M182205

Summaries for C3orf70 Gene

GeneCards Summary for C3orf70 Gene

C3orf70 (Chromosome 3 Open Reading Frame 70) is a Protein Coding gene.

Additional gene information for C3orf70 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C3orf70 Gene

Genomics for C3orf70 Gene

GeneHancer (GH) Regulatory Elements for C3orf70 Gene

Promoters and enhancers for C3orf70 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J185151 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 505.8 +1.3 1259 4.4 POLR2G ZFX ZIC2 GABPA ZBTB26 RFX1 CTBP1 ZNF341 EZH2 HDAC2 C3orf70 TRA2B VPS8 POLR2H RF00017-4195
GH03J185154 Enhancer 0.5 ENCODE 500.7 -1.2 -1248 0.2 POLR2A HIC1 SMARCA4 MAX ZNF280C EZH2 PRDM2 C3orf70 TRA2B POLR2H EHHADH-AS1
GH03J185174 Enhancer 1.1 ENCODE CraniofacialAtlas 11.8 -22.8 -22809 1.8 CTCF POLR2G GTF2E2 KDM6A ZBTB11 REST ZNF740 TOE1 MYC ZBTB7A C3orf70 VPS8 EHHADH-AS1 piR-41406-047
GH03J185316 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10 -164.4 -164387 2.3 NCOR1 POLR2A RELA EP300 SKI TEAD1 ATF2 NR2F2 FOXA2 ZNF316 MAP3K13 EHHADH C3orf70 lnc-EHHADH-2 piR-50391-008
GH03J185282 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6 -130.0 -130041 2.6 ZBTB40 ZNF217 EP300 POLR2G SP1 NCOR1 PHF8 JUND TEAD4 ZNF639 MAP3K13 EHHADH lnc-EHHADH-1 C3orf70 lnc-EHHADH-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C3orf70 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C3orf70

Top Transcription factor binding sites by QIAGEN in the C3orf70 gene promoter:
  • AhR
  • Arnt
  • Chx10
  • GATA-2
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • STAT5B

Genomic Locations for C3orf70 Gene

Genomic Locations for C3orf70 Gene
chr3:185,076,838-185,153,060
(GRCh38/hg38)
Size:
76,223 bases
Orientation:
Minus strand
chr3:184,795,838-184,870,802
(GRCh37/hg19)
Size:
74,965 bases
Orientation:
Minus strand

Genomic View for C3orf70 Gene

Genes around C3orf70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf70 Gene

Proteins for C3orf70 Gene

  • Protein details for C3orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLC5-CC070_HUMAN
    Recommended name:
    UPF0524 protein C3orf70
    Protein Accession:
    A6NLC5
    Secondary Accessions:
    • B2RNY2
    • B9EH83

    Protein attributes for C3orf70 Gene

    Size:
    250 amino acids
    Molecular mass:
    27769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3orf70 Gene

Post-translational modifications for C3orf70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C3orf70 Gene

Domains & Families for C3orf70 Gene

Gene Families for C3orf70 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for C3orf70 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C3orf70 Gene

GenScript: Design optimal peptide antigens:
  • UPF0524 protein C3orf70 (CC070_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NLC5

UniProtKB/Swiss-Prot:

CC070_HUMAN :
  • Belongs to the UPF0524 family.
Family:
  • Belongs to the UPF0524 family.
genes like me logo Genes that share domains with C3orf70: view

Function for C3orf70 Gene

Phenotypes From GWAS Catalog for C3orf70 Gene

Phenotypes for C3orf70 Gene

genes like me logo Genes that share phenotypes with C3orf70: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf70 Gene

Localization for C3orf70 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf70 gene
Compartment Confidence
cytosol 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf70 Gene

Pathways & Interactions for C3orf70 Gene

PathCards logo

SuperPathways for C3orf70 Gene

No Data Available

Interacting Proteins for C3orf70 Gene

Selected Interacting proteins: A6NLC5-CC070_HUMAN for C3orf70 Gene via IID

Symbol External ID(s) Details
RBM3
;

Gene Ontology (GO) - Biological Process for C3orf70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf70 Gene

Drugs & Compounds for C3orf70 Gene

No Compound Related Data Available

Transcripts for C3orf70 Gene

mRNA/cDNA for C3orf70 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf70 Gene

No ASD Table

Relevant External Links for C3orf70 Gene

GeneLoc Exon Structure for
C3orf70

Expression for C3orf70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C3orf70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C3orf70

SOURCE GeneReport for Unigene cluster for C3orf70 Gene:

Hs.380048
genes like me logo Genes that share expression patterns with C3orf70: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf70 Gene

Orthologs for C3orf70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3orf70 31
  • 100 (a)
OneToOne
C3H3orf70 30
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia C3orf70 31
  • 97 (a)
OneToOne
C1H3orf70 30
  • 92.93 (n)
dog
(Canis familiaris)
Mammalia C3orf70 31
  • 96 (a)
OneToOne
C34H3orf70 30
  • 93.73 (n)
oppossum
(Monodelphis domestica)
Mammalia C3orf70 31
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562339 30
  • 89.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf70 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2510009E07Rik 17 31 30
  • 88.71 (n)
chicken
(Gallus gallus)
Aves C9H3orf70 30
  • 78.28 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494388 30
  • 69.83 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-22o12.2 30
  • 66.67 (n)
C9H3orf70 (1 of 2) 31
  • 61 (a)
OneToMany
C1H3orf70 (2 of 2) 31
  • 58 (a)
OneToMany
Species where no ortholog for C3orf70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf70 Gene

ENSEMBL:
Gene Tree for C3orf70 (if available)
TreeFam:
Gene Tree for C3orf70 (if available)

Paralogs for C3orf70 Gene

No data available for Paralogs for C3orf70 Gene

Variants for C3orf70 Gene

Additional dbSNP identifiers (rs#s) for C3orf70 Gene

Structural Variations from Database of Genomic Variants (DGV) for C3orf70 Gene

Variant ID Type Subtype PubMed ID
dgv5002n100 CNV gain 25217958
esv3598958 CNV gain 21293372
esv3598961 CNV loss 21293372
esv3598962 CNV loss 21293372
nsv521893 CNV loss 19592680
nsv950020 CNV deletion 24416366

Variation tolerance for C3orf70 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C3orf70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C3orf70 Gene

Disorders for C3orf70 Gene

Additional Disease Information for C3orf70

No disorders were found for C3orf70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf70 Gene

Publications for C3orf70 Gene

  1. C3orf70 Is Involved in Neural and Neurobehavioral Development. (PMID: 31623237) Ashikawa Y … Nishimura Y (Pharmaceuticals (Basel, Switzerland) 2019) 2 3 54
  2. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. (PMID: 21042317) Wray NR … Sullivan PF (Molecular psychiatry 2012) 3 41 54
  3. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 54
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for C3orf70 Gene

Sources for C3orf70 Gene