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Aliases for C3orf52 Gene

Aliases for C3orf52 Gene

  • Chromosome 3 Open Reading Frame 52 2 3 5
  • TPA Induced Trans-Membrane Protein 2 3
  • TTMP 3 4
  • Novel Endoplasmic Reticulum Transmembrane Protein 3
  • TPA-Induced Transmembrane Protein 3

External Ids for C3orf52 Gene

Previous GeneCards Identifiers for C3orf52 Gene

  • GC03P113289
  • GC03P111805
  • GC03P109180

Summaries for C3orf52 Gene

GeneCards Summary for C3orf52 Gene

C3orf52 (Chromosome 3 Open Reading Frame 52) is a Protein Coding gene.

Additional gene information for C3orf52 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf52 Gene

Genomics for C3orf52 Gene

GeneHancer (GH) Regulatory Elements for C3orf52 Gene

Promoters and enhancers for C3orf52 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I112083 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.3 -272 4.5 HDGF PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ZNF121 C3orf52 SLC9C1 ENSG00000261488 MIR567 ABHD10 GCSAM TMPRSS7
GH03I112634 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.3 +553.3 553259 10.2 PKNOX1 ZNF133 SIN3A ZNF2 POLR2B ARID2 ZNF143 FOS RUNX3 DEK CCDC80 CD200R1 ENSG00000242770 SPICE1 C3orf52 MIR567 SLC35A5 LINC01279
GH03I112559 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.4 +475.3 475269 4.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC35A5 ATG3 SPICE1 NEPRO LOC101180897 CFAP44 BOC CCDC80 MIR567 C3orf52
GH03I112494 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +411.8 411798 6.3 PKNOX1 RB1 JUN IRF4 RELA POLR2A ETV6 BCLAF1 IKZF2 RUNX3 BTLA SLC35A5 CD200 MIR567 C3orf52 LOC105374041
GH03I112462 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +378.4 378379 3.9 HDGF PKNOX1 SMAD1 RB1 BATF ATF7 ETV6 BCLAF1 IKZF2 RUNX3 BTLA CD200 MIR567 C3orf52 SLC35A5 LOC105374041
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C3orf52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C3orf52 gene promoter:

Genomic Locations for C3orf52 Gene

Genomic Locations for C3orf52 Gene
chr3:112,086,335-112,131,095
(GRCh38/hg38)
Size:
44,761 bases
Orientation:
Plus strand
chr3:111,805,182-111,849,851
(GRCh37/hg19)

Genomic View for C3orf52 Gene

Genes around C3orf52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf52 Gene

Proteins for C3orf52 Gene

  • Protein details for C3orf52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BVD1-TTMP_HUMAN
    Recommended name:
    TPA-induced transmembrane protein
    Protein Accession:
    Q5BVD1
    Secondary Accessions:
    • B4DNV2
    • B4E0Z2
    • Q96AJ4
    • Q9H5Q1

    Protein attributes for C3orf52 Gene

    Size:
    217 amino acids
    Molecular mass:
    24295 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17064.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15569.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305}; Sequence=BAG60364.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C3orf52 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf52 Gene

Post-translational modifications for C3orf52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf52 Gene

No data available for DME Specific Peptides for C3orf52 Gene

Domains & Families for C3orf52 Gene

Gene Families for C3orf52 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C3orf52 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C3orf52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf52: view

No data available for UniProtKB/Swiss-Prot for C3orf52 Gene

Function for C3orf52 Gene

Molecular function for C3orf52 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) in the pancreatic cancer cell line HPAF-II. The up-regulation by TPA is triggered at the promoter level.

Phenotypes From GWAS Catalog for C3orf52 Gene

Gene Ontology (GO) - Molecular Function for C3orf52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C3orf52: view
genes like me logo Genes that share phenotypes with C3orf52: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf52 Gene

Localization for C3orf52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf52 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf52 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C3orf52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf52: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C3orf52 Gene

Pathways & Interactions for C3orf52 Gene

SuperPathways for C3orf52 Gene

No Data Available

Interacting Proteins for C3orf52 Gene

Gene Ontology (GO) - Biological Process for C3orf52 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf52 Gene

Drugs & Compounds for C3orf52 Gene

No Compound Related Data Available

Transcripts for C3orf52 Gene

Unigene Clusters for C3orf52 Gene

Chromosome 3 open reading frame 52:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf52 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - -
SP2: - - - - - - - -
SP3:
SP4: -
SP5: -

Relevant External Links for C3orf52 Gene

GeneLoc Exon Structure for
C3orf52
ECgene alternative splicing isoforms for
C3orf52

Expression for C3orf52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C3orf52 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.2), Skin - Not Sun Exposed (Suprapubic) (x8.8), and Pancreas (x6.0).

Protein differential expression in normal tissues from HIPED for C3orf52 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (62.6) and Colon (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C3orf52 Gene



Protein tissue co-expression partners for C3orf52 Gene

NURSA nuclear receptor signaling pathways regulating expression of C3orf52 Gene:

C3orf52

SOURCE GeneReport for Unigene cluster for C3orf52 Gene:

Hs.434247

Evidence on tissue expression from TISSUES for C3orf52 Gene

  • Intestine(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with C3orf52: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf52 Gene

Orthologs for C3orf52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf52 33
  • 98.77 (n)
C3orf52 34
  • 63 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H3orf52 33
  • 79.42 (n)
C3orf52 34
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C33H3orf52 33
  • 79.3 (n)
C3orf52 34
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685680 33
  • 76.21 (n)
mouse
(Mus musculus)
Mammalia BC016579 33 16 34
  • 76.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf52 34
  • 24 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H3ORF52 33
  • 52.38 (n)
C3orf52 34
  • 17 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf52 34
  • 19 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf52 33
  • 47.13 (n)
Species where no ortholog for C3orf52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf52 Gene

ENSEMBL:
Gene Tree for C3orf52 (if available)
TreeFam:
Gene Tree for C3orf52 (if available)

Paralogs for C3orf52 Gene

(1) SIMAP similar genes for C3orf52 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C3orf52: view

No data available for Paralogs for C3orf52 Gene

Variants for C3orf52 Gene

Sequence variations from dbSNP and Humsavar for C3orf52 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000188231 -- 112,098,757(+) C/T intron_variant
rs1000197956 -- 112,098,585(+) T/C intron_variant
rs1000217342 -- 112,101,297(+) G/A intron_variant
rs1000308416 -- 112,091,864(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000387689 -- 112,086,401(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf52 Gene

Variant ID Type Subtype PubMed ID
dgv919e214 CNV gain 21293372

Variation tolerance for C3orf52 Gene

Gene Damage Index Score: 1.44; 28.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C3orf52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf52 Gene

Disorders for C3orf52 Gene

Additional Disease Information for C3orf52

No disorders were found for C3orf52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf52 Gene

Publications for C3orf52 Gene

  1. Identification and in silico characterization of a novel gene: TPA induced trans-membrane protein. (PMID: 15737651) Chan CY … Adrian TE (Biochemical and biophysical research communications 2005) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for C3orf52 Gene

Sources for C3orf52 Gene

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